Chromosome clustering in mitosis by the nuclear protein Ki-67.
Ki-67
chromosomes
mitosis
Journal
Biochemical Society transactions
ISSN: 1470-8752
Titre abrégé: Biochem Soc Trans
Pays: England
ID NLM: 7506897
Informations de publication
Date de publication:
17 12 2021
17 12 2021
Historique:
received:
03
09
2021
revised:
21
10
2021
accepted:
25
10
2021
pubmed:
17
11
2021
medline:
2
4
2022
entrez:
16
11
2021
Statut:
ppublish
Résumé
Ki-67 is highly expressed in proliferating cells, a characteristic that made the protein a very important proliferation marker widely used in the clinic. However, the molecular functions and properties of Ki-67 remained quite obscure for a long time. Only recently important discoveries have shed some light on its function and shown that Ki-67 has a major role in the formation of mitotic chromosome periphery compartment, it is associated with protein phosphatase one (PP1) and regulates chromatin function in interphase and mitosis. In this review, we discuss the role of Ki-67 during cell division. Specifically, we focus on the importance of Ki-67 in chromosome individualisation at mitotic entry (prometaphase) and its contribution to chromosome clustering and nuclear remodelling during mitotic exit.
Identifiants
pubmed: 34783345
pii: 230250
doi: 10.1042/BST20210717
pmc: PMC8786303
doi:
Substances chimiques
Ki-67 Antigen
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
2767-2776Subventions
Organisme : Wellcome Trust
Pays : United Kingdom
Organisme : Wellcome Trust
ID : 210742/Z/18/Z
Pays : United Kingdom
Informations de copyright
© 2021 The Author(s).
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