Right ventricular function during trastuzumab therapy for breast cancer.

Breast cancer Cardiotoxicity Myocardial strain Right ventricular Trastuzumab

Journal

The international journal of cardiovascular imaging
ISSN: 1875-8312
Titre abrégé: Int J Cardiovasc Imaging
Pays: United States
ID NLM: 100969716

Informations de publication

Date de publication:
16 Nov 2021
Historique:
received: 27 07 2021
accepted: 06 11 2021
entrez: 16 11 2021
pubmed: 17 11 2021
medline: 17 11 2021
Statut: aheadofprint

Résumé

Cardiotoxicity (CDT) is the main adverse effect related to trastuzumab (TTZ). The role of the right ventricle (RV) in this context is not clear. We aimed to evaluate the longitudinal changes in RV function during TTZ therapy and to determine RV function changes associated with subclinical CDT. Breast cancer patients underwent echocardiograms at the beginning of TTZ treatment (Exam 1) and every 3 months during the first year (Exams 2, 3, and 4). Subclinical CDT was defined as ≥ 12% relative reduction of left ventricle global longitudinal strain (LV GLS). Twenty-five women (52.1 ± 13.1 y-o) were included. We found a decrease in LV ejection fraction between the first and fourth exams (Ex1: 64.1% ± 4.9 vs Ex4: 60.9% ± 4.9, p = 0.003) and the LV GLS gradually decreased during follow-up (Ex1: - 20.6% ± 2.0; Ex2: - 19.4% ± 2.1; Ex3: - 19.2% ± 1.8; Ex4: - 19.0% ± 2.1, all p < 0.05). RV GLS changed from baseline to 3 month and to 6 month (Ex1: - 23.9% ± 1.6; Ex2: - 22.5% ± 2.1; Ex3: - 22.5% ± 2.3, all p < 0.05), and the RV Fractional Area Change was lower in the third exam (Ex1: 44.3% ± 6.6 vs Ex3: 39.9% ± 6.0, p = 0.004). We found subclinical CDT in 13 patients (52%); worsening in RV parameters did not differ between those with and without subclinical CDT. In this sample, the RV function decreased during TTZ therapy and the decrease was not associated to the observed LV cardiotoxicity.

Identifiants

DOI: 10.1007/s10554-021-02470-2 PMID: 34783929
pubmed: 34783929
doi: 10.1007/s10554-021-02470-2
pii: 10.1007/s10554-021-02470-2
doi:

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Subventions

Organisme : ministério da educação
ID : FIPE/GPPG CEP 2019-0010

Informations de copyright

© 2021. The Author(s), under exclusive licence to Springer Nature B.V.

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Auteurs

Géris Mazzutti (G)

Cardiology Division, Hospital de Clínicas de Porto Alegre (HCPA), Rua Ramiro Barcelos, 2350, Room 2061, Porto Alegre, RS, 90035-903, Brazil. gmazzutti@hcpa.edu.br.
Post-Graduate Program in Cardiology and Cardiovascular Sciences, Medical School, Universidade Federal do Rio Grande do Sul (UFRGS), Porto Alegre, Brazil. gmazzutti@hcpa.edu.br.
ORCID: 0000-0002-9521-5017

Fernando Pivatto Júnior (F)

Post-Graduate Program in Cardiology and Cardiovascular Sciences, Medical School, Universidade Federal do Rio Grande do Sul (UFRGS), Porto Alegre, Brazil.

Guilherme Oliveira Magalhães Costa (GOM)

Medical School, Universidade Federal do Rio Grande do Sul (UFRGS), Porto Alegre, Brazil.

Murilo Foppa (M)

Cardiology Division, Hospital de Clínicas de Porto Alegre (HCPA), Rua Ramiro Barcelos, 2350, Room 2061, Porto Alegre, RS, 90035-903, Brazil.
Post-Graduate Program in Cardiology and Cardiovascular Sciences, Medical School, Universidade Federal do Rio Grande do Sul (UFRGS), Porto Alegre, Brazil.

Andreia Biolo (A)

Cardiology Division, Hospital de Clínicas de Porto Alegre (HCPA), Rua Ramiro Barcelos, 2350, Room 2061, Porto Alegre, RS, 90035-903, Brazil.
Post-Graduate Program in Cardiology and Cardiovascular Sciences, Medical School, Universidade Federal do Rio Grande do Sul (UFRGS), Porto Alegre, Brazil.
Medical School, Universidade Federal do Rio Grande do Sul (UFRGS), Porto Alegre, Brazil.

Angela Barreto Santiago Santos (ABS)

Cardiology Division, Hospital de Clínicas de Porto Alegre (HCPA), Rua Ramiro Barcelos, 2350, Room 2061, Porto Alegre, RS, 90035-903, Brazil.
Post-Graduate Program in Cardiology and Cardiovascular Sciences, Medical School, Universidade Federal do Rio Grande do Sul (UFRGS), Porto Alegre, Brazil.

Classifications MeSH