Psychosocial Interventions to Promote Undetectable HIV Viral Loads: A Systematic Review of Randomized Clinical Trials.
AIDS
Adherence intervention
HIV
HIV viral load
Undetectable
Journal
AIDS and behavior
ISSN: 1573-3254
Titre abrégé: AIDS Behav
Pays: United States
ID NLM: 9712133
Informations de publication
Date de publication:
Jun 2022
Jun 2022
Historique:
accepted:
06
11
2021
pubmed:
17
11
2021
medline:
30
4
2022
entrez:
16
11
2021
Statut:
ppublish
Résumé
Suppressing HIV viral loads to undetectable levels is essential for ending the HIV/AIDS epidemic. We evaluated randomized controlled trials aimed to increase antiretroviral medication adherence and promote undetectable viral loads among people living with HIV through November 22, 2019. We extracted data from 51 eligible interventions and analyzed the results using random effects models to compare intervention effects between groups within each intervention and across interventions. We also evaluated the relation between publication date and treatment effects. Only five interventions increased undetectable viral loads significantly. As a whole, the analyzed interventions were superior to Standard of Care in promoting undetectable viral loads. Interventions published more recently were not more effective in promoting undetectable viral loads. No treatment category consistently produced significant increases in undetectable viral loads. To end the HIV/AIDS epidemic, we should use interventions that can suppress HIV viral loads to undetectable levels.
Identifiants
pubmed: 34783938
doi: 10.1007/s10461-021-03534-z
pii: 10.1007/s10461-021-03534-z
pmc: PMC9050821
mid: NIHMS1782014
doi:
Substances chimiques
Anti-Retroviral Agents
0
Types de publication
Journal Article
Review
Systematic Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
1853-1862Subventions
Organisme : NIAID NIH HHS
ID : R01 AI117065
Pays : United States
Organisme : NIDA NIH HHS
ID : T32 DA007209
Pays : United States
Organisme : NIDA NIH HHS
ID : T32DA07209
Pays : United States
Organisme : National Institute of Allergy and Infectious Diseases
ID : R01AI117065
Informations de copyright
© 2021. The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature.
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