Does Gender Influence the Effectiveness and Safety of Insulin Glargine 300 U/ml in Patients with Uncontrolled Type 2 Diabetes? Results from the REALI European Pooled Analysis.
Europe
Gender differences
Glycaemic control
Insulin glargine 300 U/ml
Pooled analysis
Type 2 diabetes
Journal
Diabetes therapy : research, treatment and education of diabetes and related disorders
ISSN: 1869-6953
Titre abrégé: Diabetes Ther
Pays: United States
ID NLM: 101539025
Informations de publication
Date de publication:
Jan 2022
Jan 2022
Historique:
received:
01
10
2021
accepted:
27
10
2021
pubmed:
17
11
2021
medline:
17
11
2021
entrez:
16
11
2021
Statut:
ppublish
Résumé
Gender differences in risk factors and treatment outcomes for type 2 diabetes mellitus (T2DM) may exist. We used the REALI European database to investigate whether there were gender-specific differences in baseline characteristics and clinical outcomes among patients with inadequately controlled T2DM initiated on insulin glargine 300 U/ml (Gla-300). Data were pooled from 14 multicentre, prospective, interventional and non-interventional studies. Impact of gender on glycaemic control, insulin dose, body weight and hypoglycaemia was evaluated after 12 and 24 weeks of Gla-300 treatment. Women (N = 3857) were older than men (N = 4376) (median age, 65.0 versus 63.0 years), with greater mean body mass index (32.5 versus 31.6 kg/m Despite some gender differences in baseline characteristics, Gla-300 treatment improved glycaemic control, with overall low hypoglycaemia incidences in both men and women. However, women had statistically significantly lower HbA1c reductions than men, although these differences were clinically modest.
Identifiants
pubmed: 34784005
doi: 10.1007/s13300-021-01179-8
pii: 10.1007/s13300-021-01179-8
pmc: PMC8776923
doi:
Types de publication
Journal Article
Langues
eng
Pagination
57-73Informations de copyright
© 2021. The Author(s).
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