Production, Isolation, and Characterization of Bioengineered Bacterial Extracellular Membrane Vesicles Derived from Bacteroides thetaiotaomicron and Their Use in Vaccine Development.
Bacterial extracellular vesicles
Bacteroides thetaiotaomicron
Crossflow ultrafiltration
Immunization
Vaccines
Journal
Methods in molecular biology (Clifton, N.J.)
ISSN: 1940-6029
Titre abrégé: Methods Mol Biol
Pays: United States
ID NLM: 9214969
Informations de publication
Date de publication:
2022
2022
Historique:
entrez:
16
11
2021
pubmed:
17
11
2021
medline:
25
11
2021
Statut:
ppublish
Résumé
Bacterial extracellular vesicles (BEVs) possess features that make them well suited for the delivery of therapeutics and vaccines. This chapter describes methods for engineering the commensal human intestinal bacterium Bacteroides thetaiotaomicron (Bt) to produce BEVs carrying vaccine antigens and accompanying methods for isolating and purifying BEVs for mucosal vaccination regimens.
Identifiants
pubmed: 34784038
doi: 10.1007/978-1-0716-1900-1_11
doi:
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
171-190Subventions
Organisme : Biotechnology and Biological Sciences Research Council
ID : BB/L004291/1
Pays : United Kingdom
Organisme : Biotechnology and Biological Sciences Research Council
ID : BBS/E/F000PR10355
Pays : United Kingdom
Organisme : Biotechnology and Biological Sciences Research Council
ID : BB/R012490/1
Pays : United Kingdom
Organisme : Biotechnology and Biological Sciences Research Council
ID : BB/J004529/1
Pays : United Kingdom
Organisme : Biotechnology and Biological Sciences Research Council
ID : BBS/E/F/000PR10355
Pays : United Kingdom
Informations de copyright
© 2022. The Author(s), under exclusive license to Springer Science+Business Media, LLC, part of Springer Nature.
Références
Rauch S, Jasny E, Schmidt KE et al (2018) New vaccine technologies to combat outbreak situations. Front Immunol 9:1963. https://doi.org/10.3389/fimmu.2018.01963
doi: 10.3389/fimmu.2018.01963
pubmed: 30283434
pmcid: 6156540
Wallis J, Shenton DP, Carlisle RC (2019) Novel approaches for the design, delivery and administration of vaccine technologies. Clin Exp Immunol 196:189–204. https://doi.org/10.1111/cei.13287
doi: 10.1111/cei.13287
pubmed: 30963549
pmcid: 6468175
Francis MJ (2018) Recent advances in vaccine technologies. Vet Clin North Am Small Anim Pract 48:231–241. https://doi.org/10.1016/j.cvsm.2017.10.002
doi: 10.1016/j.cvsm.2017.10.002
pubmed: 29217317
Shin MD, Shukla S, Chung YH et al (2020) COVID-19 vaccine development and a potential nanomaterial path forward. Nat Nanotechnol 15:646–655. https://doi.org/10.1038/s41565-020-0737-y
doi: 10.1038/s41565-020-0737-y
pubmed: 32669664
Schwechheimer C, Kuehn MJ (2015) Outer-membrane vesicles from gram-negative bacteria: biogenesis and functions. Nat Rev Microbiol 13:605–619. https://doi.org/10.1038/nrmicro3525
doi: 10.1038/nrmicro3525
pubmed: 26373371
pmcid: 5308417
Arigita C, Jiskoot W, Westdijk J et al (2004) Stability of mono- and trivalent meningococcal outer membrane vesicle vaccines. Vaccine 22:629–642. https://doi.org/10.1016/j.vaccine.2003.08.027
doi: 10.1016/j.vaccine.2003.08.027
pubmed: 14741154
Kanojia G, Raeven RHM, van der Maas L et al (2018) Development of a thermostable spray dried outer membrane vesicle pertussis vaccine for pulmonary immunization. J Control Release 286:167–178. https://doi.org/10.1016/j.jconrel.2018.07.035
doi: 10.1016/j.jconrel.2018.07.035
pubmed: 30048656
Carvalho AL, Fonseca S, Cross K et al (2019) Bioengineering commensal bacteria-derived outer membrane vesicles for delivery of biologics to the gastrointestinal and respiratory tract. J Extracell Vesicles 8:1632100. https://doi.org/10.1080/20013078.2019.1632100
doi: 10.1080/20013078.2019.1632100
pubmed: 31275534
pmcid: 6598475
Chen DJ, Osterrieder N, Metzger SM et al (2010) Delivery of foreign antigens by engineered outer membrane vesicle vaccines. Proc Natl Acad Sci U S A 107:3099–3104. https://doi.org/10.1073/pnas.0805532107
doi: 10.1073/pnas.0805532107
pubmed: 20133740
pmcid: 2840271
Stentz R, Carvalho AL, Jones EJ et al (2018) Fantastic voyage: the journey of intestinal microbiota-derived microvesicles through the body. Biochem Soc Trans 46:1021–1027. https://doi.org/10.1042/BST20180114
doi: 10.1042/BST20180114
pubmed: 30154095
pmcid: 6195637
Cecil JD, Sirisaengtaksin N, O'Brien-Simpson NM et al (2019) Outer membrane vesicle-host cell interactions. Microbiol Spectr 7. https://doi.org/10.1128/microbiolspec.PSIB-0001-2018
Jones EJ, Booth C, Fonseca S et al (2020) The uptake, trafficking, and biodistribution of Bacteroides thetaiotaomicron generated outer membrane vesicles. Front Microbiol 11:57. https://doi.org/10.3389/fmicb.2020.00057
doi: 10.3389/fmicb.2020.00057
pubmed: 32117106
pmcid: 7015872
Miquel-Clopés A, Bentley EG, Stewart JP et al (2019) Mucosal vaccines and technology. Clin Exp Immunol 196:205–214. https://doi.org/10.1111/cei.13285
doi: 10.1111/cei.13285
pubmed: 30963541
pmcid: 6468177
Smith CJ, Rocha ER, Paster BJ (2006) The medically important Bacteroides spp. in health and disease. In: Dworkin M, Falkow S, Rosenberg E, Schleifer KH, Stackebrandt E (eds) The prokaryotes. Springer, New York, NY. https://doi.org/10.1007/0-387-30747-8_14
doi: 10.1007/0-387-30747-8_14
Human Microbiome Project Consortium (2012) Structure, function and diversity of the healthy human microbiome. Nature 486:207–214. https://doi.org/10.1038/nature11234
doi: 10.1038/nature11234
Carvalho AL, Miquel-Clopés A, Wegmann U et al (2019) Use of bioengineered human commensal gut bacteria-derived microvesicles for mucosal plague vaccine delivery and immunisation. Clin Exp Immunol 196:287–304. https://doi.org/10.1111/cei.13301
doi: 10.1111/cei.13301
pubmed: 30985006
pmcid: 6514708
Valkenburg SA, Mallajosyula VV, Li OT et al (2016) Stalking influenza by vaccination with pre-fusion headless HA mini-stem. Sci Rep 6:22666. https://doi.org/10.1038/srep22666
doi: 10.1038/srep22666
pubmed: 26947245
pmcid: 4780079
Wegmann U, Horn N, Carding SR (2013) Defining the Bacteroides ribosomal binding site. Appl Environ Microbiol 79:1980–1989. https://doi.org/10.1128/AEM.03086-12
doi: 10.1128/AEM.03086-12
Shoemaker NB, Getty C, Gardner JF et al (1986) Tn4351 transposes in Bacteroides spp. and mediates the integration of plasmid R751 into the Bacteroides chromosome. J Bacteriol 165:929–936. https://doi.org/10.1128/jb.165.3.929-936.1986
doi: 10.1128/jb.165.3.929-936.1986
pubmed: 3005243
pmcid: 214518
Bryant WA, Stentz R, Le Gall G et al (2017) In silico analysis of the small molecule content of outer membrane vesicles produced by Bacteroides thetaiotaomicron indicates an extensive metabolic link between microbe and host. Front Microbiol 8:2440. https://doi.org/10.3389/fmicb.2017.02440
doi: 10.3389/fmicb.2017.02440
pubmed: 29276507
pmcid: 5727896
Horn N, Carvalho AL, Overweg K et al (2016) A novel tightly regulated gene expression system for the human intestinal symbiont Bacteroides thetaiotaomicron. Front Microbiol 7:1080. https://doi.org/10.3389/fmicb.2016.01080
doi: 10.3389/fmicb.2016.01080
pubmed: 27468280
pmcid: 4942465
Durant L, Stentz R, Noble A et al (2020) Bacteroides thetaiotaomicron-derived outer membrane vesicles promote regulatory dendritic cell responses in health but not in inflammatory bowel disease. Microbiome 8:88. https://doi.org/10.1186/s40168-020-00868-z
doi: 10.1186/s40168-020-00868-z
pubmed: 32513301
pmcid: 7282036