Eosinophils mediate SIgA production triggered by TLR2 and TLR4 to control Ascaris suum infection in mice.
Journal
PLoS pathogens
ISSN: 1553-7374
Titre abrégé: PLoS Pathog
Pays: United States
ID NLM: 101238921
Informations de publication
Date de publication:
11 2021
11 2021
Historique:
received:
27
11
2020
accepted:
25
10
2021
revised:
30
11
2021
pubmed:
17
11
2021
medline:
1
1
2022
entrez:
16
11
2021
Statut:
epublish
Résumé
Human ascariasis is the most prevalent but neglected tropical disease in the world, affecting approximately 450 million people. The initial phase of Ascaris infection is marked by larval migration from the host's organs, causing mechanical injuries followed by an intense local inflammatory response, which is characterized mainly by neutrophil and eosinophil infiltration, especially in the lungs. During the pulmonary phase, the lesions induced by larval migration and excessive immune responses contribute to tissue remodeling marked by fibrosis and lung dysfunction. In this study, we investigated the relationship between SIgA levels and eosinophils. We found that TLR2 and TLR4 signaling induces eosinophils and promotes SIgA production during Ascaris suum infection. Therefore, control of parasite burden during the pulmonary phase of ascariasis involves eosinophil influx and subsequent promotion of SIgA levels. In addition, we also demonstrate that eosinophils also participate in the process of tissue remodeling after lung injury caused by larval migration, contributing to pulmonary fibrosis and dysfunction in re-infected mice. In conclusion, we postulate that eosinophils play a central role in mediating host innate and humoral immune responses by controlling parasite burden, tissue inflammation, and remodeling during Ascaris suum infection. Furthermore, we suggest that the use of probiotics can induce eosinophilia and SIgA production and contribute to controlling parasite burden and morbidity of helminthic diseases with pulmonary cycles.
Identifiants
pubmed: 34784389
doi: 10.1371/journal.ppat.1010067
pii: PPATHOGENS-D-20-02562
pmc: PMC8631680
doi:
Substances chimiques
Immunoglobulin A, Secretory
0
Toll-Like Receptor 2
0
Toll-Like Receptor 4
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
e1010067Déclaration de conflit d'intérêts
The authors have declared that no competing interests exist.
Références
Vet Parasitol. 2011 Feb 10;175(3-4):382-5
pubmed: 21074327
J Exp Med. 1983 Feb 1;157(2):433-50
pubmed: 6185611
Infect Immun. 2002 Nov;70(11):6263-72
pubmed: 12379705
BMC Biotechnol. 2020 Jul 23;20(1):38
pubmed: 32703192
Nat Immunol. 2011 Feb;12(2):151-9
pubmed: 21217761
Cell Immunol. 2011;267(2):77-87
pubmed: 21185554
Annu Rev Immunol. 1990;8:303-33
pubmed: 1693082
PLoS Negl Trop Dis. 2013 Dec 05;7(12):e2588
pubmed: 24340121
Trends Parasitol. 2018 Oct;34(10):861-880
pubmed: 30177466
PLoS One. 2017 Mar 20;12(3):e0173917
pubmed: 28319123
Front Immunol. 2012 Aug 28;3:270
pubmed: 22973272
PLoS Negl Trop Dis. 2019 Nov 25;13(11):e0007896
pubmed: 31765381
Nat Rev Immunol. 2014 Mar;14(3):141-53
pubmed: 24566914
Immunity. 1996 Jan;4(1):15-24
pubmed: 8574848
BMC Immunol. 2016 May 31;17(1):12
pubmed: 27245920
PLoS One. 2014 Aug 21;9(8):e105370
pubmed: 25144744
Lancet. 2015 Aug 22;386(9995):743-800
pubmed: 26063472
Mol Immunol. 2007 Feb;44(6):1401-8
pubmed: 16777227
Vet Immunol Immunopathol. 2006 Jul 15;112(1-2):62-6
pubmed: 16684572
Genes (Basel). 2021 Jan 29;12(2):
pubmed: 33572768
Front Immunol. 2013 Aug 06;4:222
pubmed: 23964273
Eur J Immunol. 2012 May;42(5):1106-16
pubmed: 22539286
Infect Immun. 2005 Dec;73(12):8291-7
pubmed: 16299326
EBioMedicine. 2020 Oct;60:102974
pubmed: 32927272
PLoS Negl Trop Dis. 2016 Aug 04;10(8):e0004837
pubmed: 27490109
J Biol Chem. 2002 Dec 13;277(50):48122-9
pubmed: 12359728
Proc Natl Acad Sci U S A. 2013 Jun 11;110(24):9914-9
pubmed: 23716700
Immunity. 2014 Apr 17;40(4):582-93
pubmed: 24745334
J Immunol Methods. 1985 Nov 7;83(2):209-15
pubmed: 3840509
Nat Rev Dis Primers. 2020 May 28;6(1):44
pubmed: 32467581
Parasite Immunol. 2020 Jul;42(7):e12717
pubmed: 32249432
J Mol Biol. 2003 Mar 28;327(3):645-57
pubmed: 12634059
Mucosal Immunol. 2015 Jul;8(4):930-42
pubmed: 25563499
Front Immunol. 2012 Feb 01;3:8
pubmed: 22566894
J Allergy Clin Immunol. 2005 Oct;116(4):827-35
pubmed: 16210057
Am J Trop Med Hyg. 2011 Feb;84(2):321-4
pubmed: 21292908
Mucosal Immunol. 2020 Sep;13(5):777-787
pubmed: 32518365
Parasite Immunol. 2011 Apr;33(4):199-209
pubmed: 21392041
Front Physiol. 2015 Nov 09;6:312
pubmed: 26617525
Infect Immun. 2018 Nov 20;86(12):
pubmed: 30249744
Front Immunol. 2018 Nov 09;9:2535
pubmed: 30473693
PLoS Negl Trop Dis. 2016 Jan 27;10(1):e0004382
pubmed: 26814713
Annu Rev Immunol. 2006;24:147-74
pubmed: 16551246
Clin Exp Immunol. 2016 Jan;183(1):57-64
pubmed: 26291602
Eur J Immunol. 2006 Apr;36(4):810-6
pubmed: 16541472
Lancet. 2018 Nov 10;392(10159):1789-1858
pubmed: 30496104
Mucosal Immunol. 2008 Jan;1(1):11-22
pubmed: 19079156
Vet Parasitol. 1998 Feb 28;75(2-3):181-90
pubmed: 9637219
Microbes Infect. 2007 Jan;9(1):28-34
pubmed: 17196865
Curr Opin Immunol. 2014 Dec;31:115-20
pubmed: 25459003
Front Immunol. 2020 Oct 15;11:557960
pubmed: 33178185
Int Arch Allergy Immunol. 2015;168(2):138-46
pubmed: 26745257
Immunity. 2015 Sep 15;43(3):527-40
pubmed: 26362264
J Clin Invest. 2019 Aug 5;129(9):3686-3701
pubmed: 31380805
Sci Rep. 2015 Oct 14;5:15066
pubmed: 26463758
Gut Pathog. 2014 Jul 29;6:33
pubmed: 25110521
Clin Vaccine Immunol. 2006 Feb;13(2):219-26
pubmed: 16467329
Int J Parasitol. 2002 Oct;32(11):1389-98
pubmed: 12350374
Immunity. 2009 Mar 20;30(3):317-9
pubmed: 19303384
J Inflamm (Lond). 2010 Nov 25;7:57
pubmed: 21108806
J Exp Med. 2016 Apr 4;213(4):555-67
pubmed: 26951334
Microorganisms. 2021 Apr 14;9(4):
pubmed: 33919849
Cell Tissue Res. 2011 Jan;343(1):57-83
pubmed: 21042920
Eur J Immunol. 1989 Jun;19(6):965-9
pubmed: 2787753
Parasite Immunol. 2006 Mar;28(3):107-15
pubmed: 16441509
Eur J Immunol. 2020 Jun;50(6):783-794
pubmed: 32065660
Mucosal Immunol. 2017 May;10(3):661-672
pubmed: 27805618
Int J Parasitol. 2013 Aug;43(9):697-706
pubmed: 23665127
Nat Immunol. 2013 Jun;14(6):536-42
pubmed: 23685824
Exp Biol Med (Maywood). 2017 Jan;242(1):8-21
pubmed: 27550926
Parasitol Int. 2003 Mar;52(1):71-9
pubmed: 12543149
Curr Opin Immunol. 2007 Jun;19(3):268-74
pubmed: 17433875
Immunity. 2014 Mar 20;40(3):425-35
pubmed: 24613091
Immunity. 2004 Sep;21(3):379-90
pubmed: 15357949
Curr Top Microbiol Immunol. 2008;319:105-30
pubmed: 18080416
PLoS Negl Trop Dis. 2013;7(3):e2138
pubmed: 23556022
J Immunol Res. 2018 Jul 2;2018:2790627
pubmed: 30057915