Self-Assembly of Unprotected Dipeptides into Hydrogels: Water-Channels Make the Difference.


Journal

Chembiochem : a European journal of chemical biology
ISSN: 1439-7633
Titre abrégé: Chembiochem
Pays: Germany
ID NLM: 100937360

Informations de publication

Date de publication:
19 01 2022
Historique:
revised: 15 11 2021
received: 29 09 2021
pubmed: 17 11 2021
medline: 4 3 2022
entrez: 16 11 2021
Statut: ppublish

Résumé

Unprotected dipeptides are attractive building blocks for environmentally friendly hydrogel biomaterials by virtue of their low-cost and ease of preparation. This work investigates the self-assembling behaviour of the distinct stereoisomers of Ile-Phe and Phe-Ile in phosphate buffered saline (PBS) to form hydrogels, using transmission electron microscopy (TEM), attenuated total reflectance infrared spectroscopy (ATR-IR), circular dichroism (CD), and oscillatory rheometry. Each peptide purity and identity was also confirmed by

Identifiants

pubmed: 34784433
doi: 10.1002/cbic.202100518
pmc: PMC9299199
doi:

Substances chimiques

Dipeptides 0
Hydrogels 0
Water 059QF0KO0R

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

e202100518

Subventions

Organisme : University of Trieste
Organisme : CENN Nanocenter (Slovenia)
Organisme : Slovenian Research Agency
ID : P2-0089
Organisme : Slovenian Research Agency
ID : J2-3043
Organisme : Slovenian Research Agency
ID : J2-3040
Organisme : Slovenian Research Agency
ID : J2-3046
Organisme : National Institute of Chemistry (Slovenia)
ID : P1-0391

Informations de copyright

© 2021 The Authors. ChemBioChem published by Wiley-VCH GmbH.

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Auteurs

Ottavia Bellotto (O)

Department of Chemical and Pharmaceutical Sciences, University of Trieste, Via L. Giorgieri 1, 34127, Trieste, Italy.

Slavko Kralj (S)

Materials Synthesis Department, Jožef Stefan Institute, Jamova 39, 1000, Ljubljana, Slovenia.
Department of Pharmaceutical Technology, University of Ljubljana, Aškerčeva 7, 1000, Ljubljana, Slovenia.

Michele Melchionna (M)

Department of Chemical and Pharmaceutical Sciences, University of Trieste, Via L. Giorgieri 1, 34127, Trieste, Italy.
Unit of Trieste, INSTM, Via L. Giorgieri 1, 34127, Trieste, Italy.

Paolo Pengo (P)

Department of Chemical and Pharmaceutical Sciences, University of Trieste, Via L. Giorgieri 1, 34127, Trieste, Italy.

Matic Kisovec (M)

Department of Molecular Biology and Nanobiotechnology, National Institute of Chemistry, Hajdrihova 19, 1001, Ljubljana, Slovenia.

Marjetka Podobnik (M)

Department of Molecular Biology and Nanobiotechnology, National Institute of Chemistry, Hajdrihova 19, 1001, Ljubljana, Slovenia.

Rita De Zorzi (R)

Department of Chemical and Pharmaceutical Sciences, University of Trieste, Via L. Giorgieri 1, 34127, Trieste, Italy.

Silvia Marchesan (S)

Department of Chemical and Pharmaceutical Sciences, University of Trieste, Via L. Giorgieri 1, 34127, Trieste, Italy.
Unit of Trieste, INSTM, Via L. Giorgieri 1, 34127, Trieste, Italy.

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Classifications MeSH