Schistosomiasis mansoni: A new therapeutic target for ubiquinol, a natural inhibitor of neutral magnesium-dependent sphingomyelinase in murine model.
Antioxidant
Electron microscopy
Indirect immunofluorescence
Mg(2)(+)- nSMase
PZQ
Schistosoma mansoni, Lung-stage schistosomula
Ubiquinol-encapsulated niosomes
Journal
Acta tropica
ISSN: 1873-6254
Titre abrégé: Acta Trop
Pays: Netherlands
ID NLM: 0370374
Informations de publication
Date de publication:
Feb 2022
Feb 2022
Historique:
received:
12
03
2021
revised:
09
11
2021
accepted:
10
11
2021
pubmed:
18
11
2021
medline:
15
2
2022
entrez:
17
11
2021
Statut:
ppublish
Résumé
Constituting the host-parasite interface and playing a censorious role in host immune response modulation and parasite survival, tegument represents a crucial target for many antischistosomal drugs. Sphingomyelin forms a stable outer leaflet of tegumental membrane-lipid bilayer. Neutral magnesium-dependent sphingomyelinase (Mg
Identifiants
pubmed: 34785184
pii: S0001-706X(21)00409-5
doi: 10.1016/j.actatropica.2021.106231
pii:
doi:
Substances chimiques
Pharmaceutical Preparations
0
Ubiquinone
1339-63-5
Praziquantel
6490C9U457
Sphingomyelin Phosphodiesterase
EC 3.1.4.12
Magnesium
I38ZP9992A
ubiquinol
M9NL0C577Y
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
106231Informations de copyright
Copyright © 2021. Published by Elsevier B.V.