Longitudinal Association Between Muscle Loss and Mortality in Ever Smokers.
COPD
mortality
muscle wasting
sarcopenia
Journal
Chest
ISSN: 1931-3543
Titre abrégé: Chest
Pays: United States
ID NLM: 0231335
Informations de publication
Date de publication:
04 2022
04 2022
Historique:
received:
16
06
2021
revised:
25
09
2021
accepted:
23
10
2021
pubmed:
18
11
2021
medline:
13
4
2022
entrez:
17
11
2021
Statut:
ppublish
Résumé
Body composition measures, specifically low weight or reduced muscle mass, are associated with mortality in COPD, but the effect of longitudinal body composition changes is undefined. Is the longitudinal loss of fat-free mass (FFM) associated with increased mortality, including in those with initially normal or elevated body composition metrics? Participants with complete data for at least one visit in the COPDGene study (n = 9,268) and the ECLIPSE study (n = 1,760) were included and monitored for 12 and 8 years, respectively. Pectoralis muscle area (PMA) was derived from thoracic CT scans and used as a proxy for FFM. A longitudinal mixed submodel for PMA and a Cox proportional hazards submodel for survival were fitted on a joint distribution, using a shared random intercept parameter and Markov chain Monte Carlo parameter estimation. Both cohorts demonstrated a left-shifted distribution of baseline FFM, not reflected in BMI, and an increase in all-cause mortality risk associated with longitudinal loss of PMA. For each 1-cm Longitudinal loss of PMA is associated with increased all-cause mortality, regardless of BMI or initial muscle mass. Consideration of novel screening tests and further research into mechanisms contributing to muscle decline may improve risk stratification and identify novel therapeutic targets in ever smokers.
Sections du résumé
BACKGROUND
Body composition measures, specifically low weight or reduced muscle mass, are associated with mortality in COPD, but the effect of longitudinal body composition changes is undefined.
RESEARCH QUESTION
Is the longitudinal loss of fat-free mass (FFM) associated with increased mortality, including in those with initially normal or elevated body composition metrics?
STUDY DESIGN AND METHODS
Participants with complete data for at least one visit in the COPDGene study (n = 9,268) and the ECLIPSE study (n = 1,760) were included and monitored for 12 and 8 years, respectively. Pectoralis muscle area (PMA) was derived from thoracic CT scans and used as a proxy for FFM. A longitudinal mixed submodel for PMA and a Cox proportional hazards submodel for survival were fitted on a joint distribution, using a shared random intercept parameter and Markov chain Monte Carlo parameter estimation.
RESULTS
Both cohorts demonstrated a left-shifted distribution of baseline FFM, not reflected in BMI, and an increase in all-cause mortality risk associated with longitudinal loss of PMA. For each 1-cm
INTERPRETATION
Longitudinal loss of PMA is associated with increased all-cause mortality, regardless of BMI or initial muscle mass. Consideration of novel screening tests and further research into mechanisms contributing to muscle decline may improve risk stratification and identify novel therapeutic targets in ever smokers.
Identifiants
pubmed: 34785234
pii: S0012-3692(21)04290-2
doi: 10.1016/j.chest.2021.10.047
pmc: PMC9005860
pii:
doi:
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Research Support, N.I.H., Extramural
Langues
eng
Sous-ensembles de citation
IM
Pagination
960-970Subventions
Organisme : NHLBI NIH HHS
ID : R01 HL089897
Pays : United States
Organisme : NHLBI NIH HHS
ID : T32 HL007633
Pays : United States
Organisme : NHLBI NIH HHS
ID : R01 HL089856
Pays : United States
Organisme : NHLBI NIH HHS
ID : U01 HL089856
Pays : United States
Organisme : NHLBI NIH HHS
ID : K08 HL141601
Pays : United States
Organisme : NICHD NIH HHS
ID : P50 HD098593
Pays : United States
Organisme : NHLBI NIH HHS
ID : U01 HL089897
Pays : United States
Organisme : NHLBI NIH HHS
ID : R01 HL151452
Pays : United States
Investigateurs
James D Crapo
(JD)
Edwin K Silverman
(EK)
Sara Cummings
(S)
Kelley Madden
(K)
Barry J Make
(BJ)
Juliet Nabbosa
(J)
Emily Port
(E)
Serine Rashdi
(S)
Elizabeth A Regan
(EA)
Lori Stepp
(L)
Shandi Watts
(S)
Michael Weaver
(M)
Terri Beaty
(T)
Russell P Bowler
(RP)
James D Crapo
(JD)
Jeffrey L Curtis
(JL)
MeiLan K Han
(MK)
John E Hokanson
(JE)
David A Lynch
(DA)
Barry J Make
(BJ)
Elizabeth A Regan
(EA)
Edwin K Silverman
(EK)
Matthew J Strand
(MJ)
Gary Anderson
(G)
Eugene R Bleecker
(ER)
Harvey O Coxson
(HO)
Ronald G Crystal
(RG)
James C Hogg
(JC)
Michael A Province
(MA)
Stephen I Rennard
(SI)
Thomas Croxton
(T)
Weiniu Gan
(W)
Lisa A Postow
(LA)
Lisa M Viviano
(LM)
Corinne Costa-Davis
(C)
Elisha Malanga
(E)
Delia Prieto
(D)
Ruth Tal-Singer
(R)
Homayoon Farzadegan
(H)
Akila Hadji
(A)
Leena Sathe
(L)
Matthew J Strand
(MJ)
David Baraghoshi
(D)
Grace Chen
(G)
James Crooks
(J)
Ruthie Knowles
(R)
Katherine Pratte
(K)
Carla Wilson
(C)
Pearlanne T Zelarney
(PT)
James D Crapo
(JD)
Russell P Bowler
(RP)
Katerina J Kechris
(KJ)
Sonia Leach
(S)
Elizabeth A Regan
(EA)
John E Hokanson
(JE)
Erin E Austin
(EE)
Annika Czizik
(A)
Gregory Kinney
(G)
Yisha Li
(Y)
Sharon M Lutz
(SM)
Margaret F Ragland
(MF)
Nicole Richmond
(N)
Kendra A Young
(KA)
Michael Cho
(M)
Peter J Castaldi
(PJ)
Kimberly Glass
(K)
Craig Hersh
(C)
Wonji Kim
(W)
Yang-Yu Liu
(YY)
Edwin K Silverman
(EK)
Terri Beaty
(T)
Craig P Hersh
(CP)
Edwin K Silverman
(EK)
Edwin K Silverman
(EK)
Terri Beaty
(T)
Jacqueline Bidinger
(J)
Peter J Castaldi
(PJ)
Michael H Cho
(MH)
Douglas Conrad
(D)
Dawn L DeMeo
(DL)
Adel R El-Boueiz
(AR)
Marilyn G Foreman
(MG)
Auyon Ghosh
(A)
Georg Hahn
(G)
Nadia N Hansel
(NN)
Lystra P Hayden
(LP)
Craig Hersh
(C)
Brian Hobbs
(B)
Wonji Kim
(W)
Woori Kim
(W)
Christoph Lange
(C)
Sharon M Lutz
(SM)
Merry-Lynn McDonald
(ML)
Michael McGeachie
(M)
Matthew Moll
(M)
Melody Morris
(M)
Nikolaos A Patsopoulos
(NA)
Dandi Qiao
(D)
Elizabeth A Regan
(EA)
Ingo Ruczinski
(I)
Emily S Wan
(ES)
David A Lynch
(DA)
Harvey O Coxson
(HO)
Jennifer G Dy
(JG)
Sean B Fain
(SB)
Shoshana Ginsburg
(S)
Eric A Hoffman
(EA)
Stephen Humphries
(S)
Philip F Judy
(PF)
Alex Kluiber Stefanie Mason
(AK)
Andrea Oh
(A)
Clare Poynton
(C)
Joseph M Reinhardt
(JM)
James Ross
(J)
Raul San Jose Estepar
(R)
Joyce D Schroeder
(JD)
Arkadiusz Sitek
(A)
Robert M Steiner
(RM)
Edwin van Beek
(E)
Bram van Ginneken
(BV)
Eva van Rikxoort
(E)
George R Washko
(GR)
Robert Jensen
(R)
James D Crapo
(JD)
Co-Chair John E Hokanson
(CC)
Surya P Bhatt
(SP)
Richard Casaburi
(R)
Peter J Castaldi
(PJ)
Jeffrey L Curtis
(JL)
Dawn L DeMeo
(DL)
MeiLan K Han
(MK)
Craig P Hersh
(CP)
Stephen Humphries
(S)
Victor Kim
(V)
David A Lynch
(DA)
Barry J Make
(BJ)
Nirupama Putcha
(N)
Elizabeth A Regan
(EA)
Edwin K Silverman
(EK)
Matthew J Strand
(MJ)
Shandi Watts
(S)
Carla Wilson
(C)
MeiLan Han
(M)
Surya P Bhatt
(SP)
Jessica Bon
(J)
Alejandro A Diaz
(AA)
Barry J Make
(BJ)
Elizabeth Regan
(E)
Carla Wilson
(C)
Elizabeth A Regan
(EA)
Antonio Anzueto
(A)
William C Bailey
(WC)
Jessica Bon
(J)
Russell P Bowler
(RP)
James D Crapo
(JD)
Gerard J Criner
(GJ)
Mark T Dransfield
(MT)
MeiLan K Han
(MK)
John E Hokanson
(JE)
Victor Kim
(V)
Greg Kinney
(G)
Barry J Make
(BJ)
Kim Sprenger
(K)
Lori Stepp
(L)
Carla Wilson
(C)
Dawn L DeMeo
(DL)
Takis Benos
(T)
Surya P Bhatt
(SP)
Russell P Bowler
(RP)
Mark T Dransfield
(MT)
Marilyn G Foreman
(MG)
Nicola A Hanania
(NA)
Nadia N Hansel
(NN)
Karin F Hoth
(KF)
Victor Kim
(V)
Allison Lambert
(A)
Katherine Lowe
(K)
Barry J Make
(BJ)
Gabriela Oates
(G)
Trisha Parekh
(T)
Nirupama Putcha
(N)
Elizabeth A Regan
(EA)
Shandi Watts
(S)
Gloria Westney
(G)
Kendra Young
(K)
MeiLan K Han
(MK)
Nirupama Putcha
(N)
Antonio Anzueto
(A)
Aparna Balasubramanian
(A)
Surya P Bhatt
(SP)
Jessica Bon
(J)
Aladin Boriek
(A)
Russell P Bowler
(RP)
Richard Casaburi
(R)
Michael H Cho
(MH)
Douglas Conrad
(D)
Jeffrey L Curtis
(JL)
Dawn L DeMeo
(DL)
Alejandro A Diaz
(AA)
Mark T Dransfield
(MT)
Ashraf Fawzy
(A)
Nicola A Hanania
(NA)
Nadia N Hansel
(NN)
Lystra P Hayden
(LP)
Craig P Hersh
(CP)
John E Hokanson
(JE)
Karin F Hoth
(KF)
Francine Jacobson
(F)
Victor Kim
(V)
Greg Kinney
(G)
David C LaFon
(DC)
Allison Lambert
(A)
Neil MacIntyre
(N)
Barry J Make
(BJ)
Diego Maselli-Caceres
(D)
Meredith C McCormack
(MC)
Merry-Lynn McDonald
(ML)
Matthew Moll
(M)
Trisha Parekh
(T)
Elizabeth A Regan
(EA)
Frank Sciurba
(F)
Edwin K Silverman
(EK)
Xavier Soler
(X)
Robert M Steiner
(RM)
Vickram Tejwani
(V)
Edwin Jr van Beek
(EJ)
Raymond C Wade
(RC)
Emily S Wan
(ES)
George R Washko
(GR)
Shandi Watts
(S)
Mike Wells
(M)
Chris H Wendt
(CH)
Kendra Young
(K)
Jeong H Yun
(JH)
Jingzhou Zhang
(J)
James D Crapo
(JD)
Erin E Austin
(EE)
Russell P Bowler
(RP)
Peter J Castaldi
(PJ)
Lucas Gillenwater
(L)
John E Hokanson
(JE)
Stephen Humphries
(S)
Greg Kinney
(G)
Yisha Li
(Y)
Katherine E Lowe
(KE)
David A Lynch
(DA)
Barry J Make
(BJ)
Matthew Moll
(M)
Katherine A Pratte
(KA)
Margaret Ragland
(M)
Elizabeth A Regan
(EA)
Nicole Richmond
(N)
Matthew J Strand
(MJ)
Kendra Young
(K)
Elizabeth A Regan
(EA)
Amy Attaway
(A)
Jessica Bon
(J)
Richard Casaburi
(R)
Dawn L DeMeo
(DL)
Stephen Humphries
(S)
Barry J Make
(BJ)
Stefanie Mason
(S)
Merry-Lynn McDonald
(ML)
Harry B Rossiter
(HB)
Punam Kumar Saha
(PK)
Raul San Jose Estepar
(R)
George R Washko
(GR)
Shandi Watts
(S)
Ava Wilson
(A)
Kendra Young
(K)
Elizabeth A Regan
(EA)
Hannatu Amaza
(H)
Aparna Balasubramanian
(A)
Adrienne Baldomero
(A)
Surya P Bhatt
(SP)
Richard Casaburi
(R)
James Crooks
(J)
Jeffrey L Curtis
(JL)
Dawn L DeMeo
(DL)
Alejandro A Diaz
(AA)
Mark T Dransfield
(MT)
Marilyn G Foreman
(MG)
MeiLan Han
(M)
Nicola A Hanania
(NA)
Nadia N Hansel
(NN)
Karin F Hoth
(KF)
Victor Kim
(V)
Greg Kinney
(G)
Katherine Lowe
(K)
Barry J Make
(BJ)
A James Mamary
(AJ)
Gabriela Oates
(G)
James O'Brien
(J)
Trisha Parekh
(T)
Nirupama Putcha
(N)
Shandi Watts
(S)
Gloria Westney
(G)
Robert A Wise
(RA)
Kendra Young
(K)
Karin F Hoth
(KF)
Surya P Bhatt
(SP)
Sara Cummings
(S)
Annika Czizik
(A)
Dawn L DeMeo
(DL)
Mark T Dransfield
(MT)
Michelle Eakin
(M)
Jess G Fiedorowicz
(JG)
Marilyn G Foreman
(MG)
Nicola A Hanania
(NA)
Ben Henkle
(B)
Kristen Holm
(K)
Karin F Hoth
(KF)
Anand Iyer
(A)
Victor Kim
(V)
Greg Kinney
(G)
Ken M Kunisaki
(KM)
Katherine Lowe
(K)
Barry J Make
(BJ)
Merry-Lynn McDonald
(ML)
Charlene McEvoy
(C)
Takudzwa Mkorombindo
(T)
Gabriela Oates
(G)
Trisha Parekh
(T)
Elizabeth A Regan
(EA)
Gen Shinozaki
(G)
Shandi Watts
(S)
Robert A Wise
(RA)
Abebaw Yohannes
(A)
Michael H Cho
(MH)
Peter J Castaldi
(PJ)
Takis Benos
(T)
Richard Casaburi
(R)
James D Crapo
(JD)
Dawn L DeMeo
(DL)
Jennifer G Dy
(JG)
MeiLan K Han
(MK)
Lystra P Hayden
(LP)
Craig P Hersh
(CP)
Brian D Hobbs
(BD)
Greg Kinney
(G)
Sharon M Lutz
(SM)
David A Lynch
(DA)
Barry J Make
(BJ)
Bruce E Miller
(BE)
Elizabeth A Regan
(EA)
Stephen I Rennard
(SI)
Tara Retson
(T)
James Ross
(J)
Raul San Jose Estepar
(R)
Frank Sciurba
(F)
Edwin K Silverman
(EK)
Xavier Soler
(X)
Robert M Steiner
(RM)
Edwin Jr van Beek
(EJ)
Emily S Wan
(ES)
George R Washko
(GR)
Carla Wilson
(C)
Kendra Young
(K)
Jeffrey L Curtis
(JL)
Lisa McCloskey
(L)
Perry G Pernicano
(PG)
Nicola A Hanania
(NA)
Mustafa Atik
(M)
Laura Bertrand
(L)
Aladin Boriek
(A)
Thomas Monaco
(T)
Dharani Narendra
(D)
Veronica V Lenge de Rosen
(VV)
Dawn L DeMeo
(DL)
Craig P Hersh
(CP)
Kwame Badu-Danso
(K)
Alejandro A Diaz
(AA)
Lystra P Hayden
(LP)
Brian D Hobbs
(BD)
Francine L Jacobson
(FL)
Laura Kaufman
(L)
Cherie Maguire
(C)
Clare Poynton
(C)
Sophie Struble
(S)
George R Washko
(GR)
Seth Wilson
(S)
Jeong H Yun
(JH)
Jingzhou Zhang
(J)
R Graham Barr
(RG)
Casandra Almonte
(C)
John H M Austin
(JHM)
Maria Lorena Gomez Blum
(ML)
Belinda M D'Souza
(BM)
Emilay Florez
(E)
Rodney Martinez
(R)
Neil MacIntyre
(N)
Wendy Curry
(W)
H Page McAdams
(HP)
Charlotte V Reikofski
(CV)
Lacey Washington
(L)
Robert A Wise
(RA)
Aparna Balasubramanian
(A)
Robert Brown
(R)
Cheryl Clare
(C)
Marie Daniel
(M)
Ashraf Fawzy
(A)
Nadia N Hansel
(NN)
Karen Horton
(K)
Cheng Ting Tony Lin
(C)
Meredith C McCormack
(MC)
Tahira Mirza
(T)
Nirupama Putcha
(N)
Meagan Scott
(M)
Becky Shade
(B)
Richard Casaburi
(R)
Matt Budoff
(M)
Robert Calmelat
(R)
Deborah Cavanaugh
(D)
Chris Dailing
(C)
Leticia Diaz
(L)
Hans Fischer
(H)
Renee Love Indelicato
(RL)
Janos Porszasz
(J)
Harry B Rossiter
(HB)
April Soriano
(A)
William Stringer
(W)
Miriam Urrutia
(M)
Chris H Wendt
(CH)
Arianne Baldomero
(A)
Brian Bell
(B)
Miranda Deconcini
(M)
Ken M Kunisaki
(KM)
Charlene McEvoy
(C)
Linda Loes
(L)
Jonathan Phelan
(J)
Camille Robichaux
(C)
Cheryl Sasse
(C)
Joseph H Tashjian
(JH)
Eric L Flenaugh
(EL)
Kema Abson
(K)
Marilyn G Foreman
(MG)
Hirut Gebrekristos
(H)
Priscilla Johnson
(P)
Jessica Jordan
(J)
Mario Ponce
(M)
Silanath Terpenning
(S)
Gloria Westney
(G)
Derrick Wilson
(D)
Russell P Bowler
(RP)
Grace Broadhurst
(G)
Debra Dyer
(D)
Elena Engel
(E)
Jay Finigan
(J)
Andrew Hill
(A)
Alex Jones
(A)
Ryan Jones
(R)
Jordan Owen
(J)
David A Lynch
(DA)
Richard Rosiello
(R)
Nicole Andries
(N)
Mary Charpentier
(M)
Diane Kirk
(D)
David Pace
(D)
Gerard J Criner
(GJ)
David Ciccolella
(D)
Francis Cordova
(F)
Chandra Dass
(C)
Gilbert D'Alonzo
(G)
Valena Davis
(V)
Parag Desai
(P)
Dee Fehrle
(D)
Carla Grabianowski
(C)
Michael Jacobs
(M)
Laurie Jameson
(L)
Gayle M Jones
(GM)
Steven Kelsen
(S)
Victor Kim
(V)
A James Mamary
(AJ)
Nathaniel Marchetti
(N)
Francine McGonagle
(F)
Aditi Satti
(A)
Kartik Shenoy
(K)
Regina Sheridan
(R)
Maria Vega-Sanchez
(M)
Samantha Wallace
(S)
Surya P Bhatt
(SP)
Samuel Akinseye-Kolapo
(S)
William C Bailey
(WC)
Matthew Baker
(M)
Mark T Dransfield
(MT)
Arnissa Goggins
(A)
Anand Iyer
(A)
David C LaFon
(DC)
Anny McClain
(A)
Merry-Lynn McDonald
(ML)
Takudzwa Mkorombindo
(T)
Hrudaya Nath
(H)
Gabriela Oates
(G)
Trisha Parekh
(T)
Satinder P Singh
(SP)
Sushil K Sonavane
(SK)
Raymond C Wade
(RC)
Mike Wells
(M)
Elizabeth Westfall
(E)
Douglas Conrad
(D)
Marissa Gil
(M)
Tarek El Hajjaoui
(T)
Albert Hsiao
(A)
Amber Martineau
(A)
Jenna Mielke
(J)
Karl Perez
(K)
Gabriel Querido
(G)
Tara Reston
(T)
Xavier Soler
(X)
Andrew Yen
(A)
Alejandro Comellas
(A)
Spyridon Fortis
(S)
Mauricio Galizia
(M)
Eric Garcia
(E)
Karin F Hoth
(KF)
Janet Keating
(J)
Archana Laroia
(A)
Changhyun Lee
(C)
Amber Meyer
(A)
Brian Mullan
(B)
Prashant Nagpal
(P)
Oloigbe Ofori
(O)
Kim Sprenger
(K)
Sierra Suiter
(S)
Commentaires et corrections
Type : CommentIn
Informations de copyright
Copyright © 2021 American College of Chest Physicians. All rights reserved.
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