Digital PCR to quantify ChAdOx1 nCoV-19 copies in blood and tissues.
AZD1222
ChAdOx1 nCoV-19
SARS-Cov2
Vaxzevria
adenoviral vector
digital PCR
vaccination
vaccine-induced immune thrombotic thrombocytopenia (VITT)
Journal
Molecular therapy. Methods & clinical development
ISSN: 2329-0501
Titre abrégé: Mol Ther Methods Clin Dev
Pays: United States
ID NLM: 101624857
Informations de publication
Date de publication:
10 Dec 2021
10 Dec 2021
Historique:
received:
11
08
2020
revised:
01
10
2021
accepted:
06
10
2021
entrez:
17
11
2021
pubmed:
18
11
2021
medline:
18
11
2021
Statut:
epublish
Résumé
Vaccination with the adenoviral-vector-based AstraZeneca ChAdOx1 nCov-19 (Vaxzevria) vaccine is efficient and safe. However, in rare cases vaccinated individuals developed life-threatening thrombotic complications, including thrombosis in cerebral sinus and splanchnic veins. Monitoring of the applied vector
Identifiants
pubmed: 34786434
doi: 10.1016/j.omtm.2021.10.002
pii: S2329-0501(21)00159-5
pmc: PMC8566940
doi:
Types de publication
Journal Article
Langues
eng
Pagination
418-423Informations de copyright
© 2021 The Author(s).
Déclaration de conflit d'intérêts
The authors declare no conflict of interest.
Références
Exp Hematol. 2013 Jan;41(1):28-38.e3
pubmed: 22989760
Nat Med. 2021 Jun;27(6):1055-1061
pubmed: 33875890
Exp Hematol. 2015 Jun;43(6):462-8.e1
pubmed: 25795523
Blood. 2009 Feb 26;113(9):1909-18
pubmed: 19131551
N Engl J Med. 2021 Jun 10;384(23):2202-2211
pubmed: 33861525
Biotechniques. 1992 Sep;13(3):444-9
pubmed: 1389177
N Engl J Med. 2021 Jun 3;384(22):2092-2101
pubmed: 33835769
N Engl J Med. 2021 Jun 3;384(22):2124-2130
pubmed: 33835768
Nature. 2020 Mar;579(7798):265-269
pubmed: 32015508
J Virol. 2010 Oct;84(19):9987-94
pubmed: 20686029
N Engl J Med. 2021 May 20;384(20):1964-1965
pubmed: 33852795
Blood. 2021 Sep 29;:
pubmed: 34587242
Mol Ther Methods Clin Dev. 2020 Jan 15;16:172-178
pubmed: 32055645