The association of motoric cognitive risk with incident dementia and neuroimaging characteristics: The Atherosclerosis Risk in Communities Study.

Atherosclerosis / diagnostic imaging Cognition Cognitive Dysfunction / diagnostic imaging Cohort Studies Dementia / diagnostic imaging Humans Neuroimaging Neuropsychological Tests Risk Factors Syndrome
brain volume dementia gait speed motoric cognitive risk white matter

Journal

Alzheimer's & dementia : the journal of the Alzheimer's Association
ISSN: 1552-5279
Titre abrégé: Alzheimers Dement
Pays: United States
ID NLM: 101231978

Informations de publication

Date de publication:
03 2022
Historique:
revised: 05 05 2021
received: 20 01 2021
accepted: 01 06 2021
pubmed: 18 11 2021
medline: 26 4 2022
entrez: 17 11 2021
Statut: ppublish

Résumé

Motoric cognitive risk (MCR), a clinical syndrome characterized by slow gait speed and subjective cognitive complaints, has been associated with dementia risk. The neuropathological features underlying MCR remain poorly understood. The Atherosclerosis Risk in Communities (ARIC) community-based cohort study classified participants using standardized criteria as MCR+/- and mild cognitive impairment (MCI)+/- at study baseline (2011-2013). We examined the 5-year dementia risk and baseline brain structural/molecular abnormalities associated with MCR+ and MCI+ status. Of 5023 nondemented participants included, 204 were MCR+ and 1030 were MCI+. Both MCR+ and MCI+ participants demonstrated increased dementia risk. The pattern of structural brain abnormalities associated with MCR+ differed from that of MCI+. Whereas MCI+ was associated with comparatively smaller volumes in brain regions vulnerable to Alzheimer's disease pathology, MCR+ status was associated with smaller volumes in frontoparietal regions and greater white matter abnormalities. MCR may represent a predementia syndrome characterized by prominent white matter abnormalities and frontoparietal atrophy.

Identifiants

DOI: 10.1002/alz.12412 PMID: 34786837 PMC: PMC10064850
pubmed: 34786837
doi: 10.1002/alz.12412
pmc: PMC10064850
mid: NIHMS1881924
doi:

Types de publication

Journal Article Research Support, N.I.H., Extramural Research Support, N.I.H., Intramural Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

434-444

Subventions

Organisme : Intramural NIH HHS
ID : ZIA AG000348
Pays : United States
Organisme : Intramural NIH HHS
ID : ZIA AG000349
Pays : United States
Organisme : NCRR NIH HHS
ID : UL1 RR025005
Pays : United States
Organisme : NHLBI NIH HHS
ID : U01 HL096917
Pays : United States
Organisme : NHLBI NIH HHS
ID : 2U01HL096899
Pays : United States
Organisme : NHLBI NIH HHS
ID : U01 HL096902
Pays : United States
Organisme : NIA NIH HHS
ID : R01 AG040282
Pays : United States
Organisme : NHLBI NIH HHS
ID : 2U01HL096814
Pays : United States
Organisme : NHLBI NIH HHS
ID : HHSN268201700002C
Pays : United States
Organisme : NHLBI NIH HHS
ID : HHSN268201700001I
Pays : United States
Organisme : NHLBI NIH HHS
ID : HHSN268201700004I
Pays : United States
Organisme : NHLBI NIH HHS
ID : U01 HL096812
Pays : United States
Organisme : NIH HHS
ID : UL1RR025005
Pays : United States
Organisme : NIA NIH HHS
ID : K23 AG064122
Pays : United States
Organisme : NHLBI NIH HHS
ID : U01 HL096814
Pays : United States
Organisme : NIA NIH HHS
ID : AG064122
Pays : United States
Organisme : NHLBI NIH HHS
ID : HHSN268201700005C
Pays : United States
Organisme : NHLBI NIH HHS
ID : HHSN268201700001C
Pays : United States
Organisme : NHLBI NIH HHS
ID : 2U01HL096812
Pays : United States
Organisme : NHLBI NIH HHS
ID : 2U01HL096902
Pays : United States
Organisme : NHLBI NIH HHS
ID : HHSN268201700003C
Pays : United States
Organisme : NHLBI NIH HHS
ID : R01 HL070825
Pays : United States
Organisme : NHLBI NIH HHS
ID : 2U01HL096917
Pays : United States
Organisme : NIA NIH HHS
ID : R01AG040282
Pays : United States
Organisme : NHLBI NIH HHS
ID : U01 HL096899
Pays : United States
Organisme : NHLBI NIH HHS
ID : HHSN268201700004C
Pays : United States
Organisme : NIA NIH HHS
ID : K24 AG052573
Pays : United States
Organisme : NHLBI NIH HHS
ID : HHSN268201700002I
Pays : United States
Organisme : NHLBI NIH HHS
ID : HHSN268201700005I
Pays : United States
Organisme : NHLBI NIH HHS
ID : HHSN268201700003I
Pays : United States
Organisme : NIA NIH HHS
ID : AG052573
Pays : United States

Informations de copyright

© 2021 the Alzheimer's Association.

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Auteurs

Gabriela T Gomez (GT)

Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.

Rebecca F Gottesman (RF)

Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.
Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland, USA.

Kelley Pettee Gabriel (KP)

Department of Epidemiology, The University of Alabama at Birmingham, Birmingham, Alabama, USA.

Priya Palta (P)

Department of Medicine, Columbia University Medical Center, New York, New York, USA.

Alden L Gross (AL)

Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland, USA.

Anja Soldan (A)

Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.

Marilyn S Albert (MS)

Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.

Kevin J Sullivan (KJ)

Department of Medicine, Division of Geriatrics, University of Mississippi Medical Center, Jackson, Mississippi, USA.

Clifford R Jack (CR)

Department of Radiology, Mayo Clinic, Rochester, Minnesota, USA.

David S Knopman (DS)

Department of Neurology, Mayo Clinic, Rochester, Minnesota, USA.

B Gwen Windham (BG)

Department of Medicine, Division of Geriatrics, University of Mississippi Medical Center, Jackson, Mississippi, USA.

Keenan A Walker (KA)

Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.
Laboratory of Behavioral Neuroscience, Intramural Research Program, National Institute on Aging, Baltimore, Maryland, USA.

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Classifications MeSH

questionsmedicales.fr › Maladies cardiovasculaires › Maladies vasculaires › Artériopathies oblitérantes › Artériosclérose › Athérosclérose › The association of motoric cognitive risk with...
questionsmedicales.fr › Phénomènes psychologiques › Processus mentaux › Cognition › The association of motoric cognitive risk with...
questionsmedicales.fr › Troubles mentaux › Troubles neurocognitifs › Troubles de la cognition › Dysfonctionnement cognitif › The association of motoric cognitive risk with...
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questionsmedicales.fr › Troubles mentaux › Troubles neurocognitifs › Démence › The association of motoric cognitive risk with...
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