Chemical Composition and Biological Screening of the Essential Oils of Micromeria macrosiphon and M. arganietorum (Lamiaceae).
M. arganietorum
Micromeria macrosiphon
biological activities
borneol
essential oil
Journal
Chemistry & biodiversity
ISSN: 1612-1880
Titre abrégé: Chem Biodivers
Pays: Switzerland
ID NLM: 101197449
Informations de publication
Date de publication:
Dec 2021
Dec 2021
Historique:
received:
13
08
2021
accepted:
11
10
2021
pubmed:
18
11
2021
medline:
14
1
2022
entrez:
17
11
2021
Statut:
ppublish
Résumé
The chemical composition and in vitro biological activities of the essential oil (EO) of Micromeria macrosiphon Coss. and M. arganietorum (J. Emb.) R. Morales, two Lamiaceae endemic to south Morocco, were investigated. GC/MS analysis resulted in the identification of 36 metabolites from the EO of M. macrosiphon, 45 from M. arganietorum. Borneol was the major metabolite in both oils and together with related derivatives such as camphor, accounted for 2/3 of the EO of M. macrosiphon, 1/3 of those of M. arganietorum. Pinene and terpinene derivatives were also present in high proportions. From a chemotaxonomic point of view, the composition of the examined samples may be related to those of other species endemic to Macaronesia. Both EOs showed significant toxicity towards liver HepG2 and melanoma B16 4A5 tumor cell lines at 100 μg/mL; however, they were also cytotoxic towards S17 normal cell lines, with a selectivity index <1. No antibacterial activity was noticed against 52 strains at 100 μg/mL.
Identifiants
pubmed: 34786843
doi: 10.1002/cbdv.202100653
doi:
Substances chimiques
Antineoplastic Agents, Phytogenic
0
Oils, Volatile
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
e2100653Subventions
Organisme : Paris Descartes University
ID : 691247
Organisme : University of Paris
Organisme : Ibn Zohr University
Organisme : Fundação para a Ciência e a Tecnologia (FCT)
ID : UIDB/04326/2020
Organisme : Fundação para a Ciência e a Tecnologia (FCT)
ID : UIDP/00102/2020
Organisme : Fundação para a Ciência e a Tecnologia (FCT)
ID : CEECIND/00425/2017
Informations de copyright
© 2021 Wiley-VHCA AG, Zurich, Switzerland.
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