Unconventional conservation reveals structure-function relationships in the synaptonemal complex.

Animals Caenorhabditis elegans / chemistry Drosophila melanogaster / chemistry Rhabditida / chemistry Species Specificity Structure-Activity Relationship Synaptonemal Complex / chemistry
C. elegans D. melanogaster P. pacificus coiled-coil evolution evolutionary biology genetics genomics human indel meiosis synaptonemal complex

Journal

eLife
ISSN: 2050-084X
Titre abrégé: Elife
Pays: England
ID NLM: 101579614

Informations de publication

Date de publication:
17 11 2021
Historique:
received: 08 07 2021
accepted: 21 10 2021
entrez: 17 11 2021
pubmed: 18 11 2021
medline: 15 12 2021
Statut: epublish

Résumé

Functional requirements constrain protein evolution, commonly manifesting in a conserved amino acid sequence. Here, we extend this idea to secondary structural features by tracking their conservation in essential meiotic proteins with highly diverged sequences. The synaptonemal complex (SC) is a ~100-nm-wide ladder-like meiotic structure present in all eukaryotic clades, where it aligns parental chromosomes and regulates exchanges between them. Despite the conserved ultrastructure and functions of the SC, SC proteins are highly divergent within

Identifiants

DOI: 10.7554/eLife.72061 PMID: 34787570 PMC: PMC8598163
pubmed: 34787570
doi: 10.7554/eLife.72061
pii: 72061
pmc: PMC8598163
doi:
pii:

Types de publication

Journal Article Research Support, N.I.H., Extramural

Langues

eng

Sous-ensembles de citation

IM

Subventions

Organisme : NIGMS NIH HHS
ID : R35 GM128804
Pays : United States
Organisme : NIH HHS
ID : P40 OD010440
Pays : United States
Organisme : NICHD NIH HHS
ID : T32 HD007491
Pays : United States

Informations de copyright

© 2021, Kursel et al.

Déclaration de conflit d'intérêts

LK, HC, OR No competing interests declared

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Auteurs

Lisa E Kursel (LE)

School of Biological Sciences and Center for Cell and Genome Sciences, University of Utah, Salt Lake City, United States.
ORCID: 0000-0002-1178-8230

Henry D Cope (HD)

School of Biological Sciences and Center for Cell and Genome Sciences, University of Utah, Salt Lake City, United States.

Ofer Rog (O)

School of Biological Sciences and Center for Cell and Genome Sciences, University of Utah, Salt Lake City, United States.
ORCID: 0000-0001-6558-6194

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Unconventional conservation reveals...
questionsmedicales.fr › Eucaryotes › Animaux › Invertébrés › Helminthes › Nematoda › Chromadorea › Rhabditida › Rhabditoidea › Caenorhabditis › Caenorhabditis elegans › Unconventional conservation reveals...
questionsmedicales.fr › Eucaryotes › Animaux › Invertébrés › Arthropodes › Insectes › Pterygota › Neoptera › Holometabola › Diptera › Drosophilidae › Drosophila › Drosophila melanogaster › Unconventional conservation reveals...
questionsmedicales.fr › Eucaryotes › Animaux › Invertébrés › Helminthes › Nematoda › Chromadorea › Rhabditida › Unconventional conservation reveals...
questionsmedicales.fr › Phénomènes biologiques › Spécificité d'espèce › Unconventional conservation reveals...
questionsmedicales.fr › Phénomènes physiologiques › Phénomènes pharmacologiques et toxicologiques › Phénomènes pharmacologiques › Relation structure-activité › Unconventional conservation reveals...
questionsmedicales.fr › Phénomènes génétiques › Structures génétiques › Structures de chromosome › Complexe synaptonémal › Unconventional conservation reveals...