Discovery of anti-inflammatory physiological peptides that promote tissue repair by reinforcing epithelial barrier formation.
Journal
Science advances
ISSN: 2375-2548
Titre abrégé: Sci Adv
Pays: United States
ID NLM: 101653440
Informations de publication
Date de publication:
19 Nov 2021
19 Nov 2021
Historique:
entrez:
17
11
2021
pubmed:
18
11
2021
medline:
18
11
2021
Statut:
ppublish
Résumé
Epithelial barriers that prevent dehydration and pathogen invasion are established by tight junctions (TJs), and their disruption leads to various inflammatory diseases and tissue destruction. However, a therapeutic strategy to overcome TJ disruption in diseases has not been established because of the lack of clinically applicable TJ-inducing molecules. Here, we found TJ-inducing peptides (JIPs) in mice and humans that corresponded to 35 to 42 residue peptides of the C terminus of alpha 1-antitrypsin (A1AT), an acute-phase anti-inflammatory protein. JIPs were inserted into the plasma membrane of epithelial cells, which promoted TJ formation by directly activating the heterotrimeric G protein G13. In a mouse intestinal epithelial injury model established by dextran sodium sulfate, mouse or human JIP administration restored TJ integrity and strongly prevented colitis. Our study has revealed TJ-inducing anti-inflammatory physiological peptides that play a critical role in tissue repair and proposes a previously unidentified therapeutic strategy for TJ-disrupted diseases.
Identifiants
pubmed: 34788088
doi: 10.1126/sciadv.abj6895
pmc: PMC8597994
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
eabj6895Références
Nat Methods. 2007 Mar;4(3):207-14
pubmed: 17327847
Shock. 2011 Dec;36(6):560-9
pubmed: 21993444
J Clin Invest. 1991 Jun;87(6):2258-65
pubmed: 1645757
Nat Rev Dis Primers. 2016 Jul 28;2:16051
pubmed: 27465791
Small GTPases. 2014;5(4):1-15
pubmed: 25483301
Biochemistry. 2007 Jun 12;46(23):6677-87
pubmed: 17503779
Am J Physiol Renal Physiol. 2007 Feb;292(2):F828-36
pubmed: 17077385
Cold Spring Harb Perspect Biol. 2009 Aug;1(2):a002584
pubmed: 20066090
J Clin Invest. 1988 Aug;82(2):706-11
pubmed: 2841359
Cancer Res. 1954 Jan;14(1):75-80
pubmed: 13126936
Trends Biochem Sci. 2019 Feb;44(2):141-152
pubmed: 30665499
Nat Rev Mol Cell Biol. 2001 Apr;2(4):285-93
pubmed: 11283726
J Cell Biol. 1998 Oct 19;143(2):391-401
pubmed: 9786950
Hum Genomics. 2013 Oct 30;7:22
pubmed: 24172014
Elife. 2020 Jun 08;9:
pubmed: 32510320
J Biol Chem. 2008 Aug 22;283(34):23288-94
pubmed: 18583341
Semin Cell Dev Biol. 2015 Jun;42:30-8
pubmed: 25999319
FASEB J. 2010 Dec;24(12):4678-90
pubmed: 20667973
J Biol Chem. 2005 Nov 4;280(44):36701-7
pubmed: 16141214
EMBO J. 2019 Feb 15;38(4):
pubmed: 30635334
J Control Release. 2019 Sep 10;309:106-124
pubmed: 31323244
J Biol Chem. 1992 Mar 5;267(7):5005-12
pubmed: 1311327
J Membr Biol. 2002 Jul 1;188(1):33-42
pubmed: 12172645
Gastroenterology. 2016 Oct;151(4):616-32
pubmed: 27436072
Proc Natl Acad Sci U S A. 1998 Jan 6;95(1):346-51
pubmed: 9419378
Cell. 2006 Aug 25;126(4):741-54
pubmed: 16923393
J Cell Sci. 2014 Oct 1;127(Pt 19):4201-12
pubmed: 25097232
Proc Natl Acad Sci U S A. 2013 Sep 10;110(37):15007-12
pubmed: 23975926
J Clin Invest. 2019 Jul 22;129(8):2983-2993
pubmed: 31329162
J Biol Chem. 2007 Oct 12;282(41):30005-13
pubmed: 17699514
Exp Cell Res. 1978 Oct 1;116(1):1-13
pubmed: 699985
Nat Rev Mol Cell Biol. 2016 Sep;17(9):564-80
pubmed: 27353478
Biochim Biophys Acta. 2014 Aug;1840(8):2571-80
pubmed: 24631662
Exp Cell Res. 1985 Jan;156(1):103-16
pubmed: 3880701
Nat Rev Immunol. 2009 Nov;9(11):799-809
pubmed: 19855405
FASEB J. 2016 Feb;30(2):933-47
pubmed: 26527063
Proc Natl Acad Sci U S A. 1978 Jun;75(6):2669-73
pubmed: 208069
Science. 1973 May 11;180(4086):647-9
pubmed: 4573394
Cell. 2019 Oct 31;179(4):923-936.e11
pubmed: 31675499
J Biol Chem. 2004 Nov 12;279(46):47438-45
pubmed: 15339913
Am J Physiol Gastrointest Liver Physiol. 2012 Mar 1;302(5):G504-14
pubmed: 22173918
Nature. 2007 Oct 25;449(7165):1003-7
pubmed: 17934449
Cold Spring Harb Perspect Biol. 2018 Jan 2;10(1):
pubmed: 28507021
Breast Cancer Res Treat. 2010 Aug;123(1):73-86
pubmed: 19902353
Proc Natl Acad Sci U S A. 1982 May;79(10):3129-33
pubmed: 6954463
Nucleic Acids Res. 2017 Jan 4;45(D1):D1107-D1111
pubmed: 27899654
J Clin Lab Anal. 2005;19(1):16-21
pubmed: 15645467
J Biol Chem. 1994 Oct 14;269(41):25849-55
pubmed: 7523394
J Diabetes Sci Technol. 2014 Nov;8(6):1193-203
pubmed: 25155845
Annu Rev Cell Dev Biol. 2011;27:213-35
pubmed: 21721945
Traffic. 2014 Jan;15(1):1-11
pubmed: 24102769
Biophys Rev. 2019 Oct;11(5):783-793
pubmed: 31586306
Biochim Biophys Acta. 1994 Mar 2;1199(2):224-8
pubmed: 8123672
J Cell Sci. 1995 Apr;108 ( Pt 4):1735-42
pubmed: 7542259