Follow-up of Nonarteritic Anterior Ischemic Optic Neuropathy With Optical Coherence Tomography Angiography.
Journal
Journal of neuro-ophthalmology : the official journal of the North American Neuro-Ophthalmology Society
ISSN: 1536-5166
Titre abrégé: J Neuroophthalmol
Pays: United States
ID NLM: 9431308
Informations de publication
Date de publication:
01 12 2021
01 12 2021
Historique:
entrez:
17
11
2021
pubmed:
18
11
2021
medline:
19
3
2022
Statut:
ppublish
Résumé
Peripapillary and macular microvasculature alterations after nonarteritic ischemic optic neuropathy (NAION) have been investigated in several studies. We aimed to explore the vascular changes from acute NAION (aNAION) to chronic NAION (cNAION). This prospective observational study composed of 16 eyes with aNAION and 40 healthy age-matched controls. Eyes with NAION were followed up for more than 6 months after acute event. Optical coherence tomography angiography (OCTA) was used to evaluate peripapillary and macular vessel densities (VDs). The customized software was used for calculating deep retinal VD to attenuate the large superficial vessel projection effect. The mean age of patients with NAION and controls was 56.13 ± 13.2 and 54.46 ± 15.5 years, respectively (P = 0.195). Radial peripapillary capillary density was significantly lower in both eyes with aNAION and eyes with cNAION than healthy eyes. Peripapillary capillary density decreased significantly from the acute to the chronic phase of NAION with values of 41.77 ± 4.05% and 34.35 ± 7.30%, respectively (P < 0.001). The mean superficial macular VD was 46.83 ± 3.47% in aNAION and 44.49 ± 4.50% in cNAION eyes with no significant difference between them (P = 0.252), but both were lower than control eyes. Deep macular VD was not affected in aNAION and cNAION eyes compared with control eyes. Correlation analysis in eyes with cNAION revealed that there were significant correlations between peripapillary nerve fiber layer and the capillary density (r = 0.772, P < 0.001) and between ganglion cell complex thickness and corresponding superficial macular VD. Although a decrease in peripapillary capillary density in aNAION eyes with active disc edema progressed when evaluated in the cNAION state, progressive VD loss was not observed in the macular area, suggesting a nonprogressive nature of macular vessel involvement in NAION.
Sections du résumé
BACKGROUND
Peripapillary and macular microvasculature alterations after nonarteritic ischemic optic neuropathy (NAION) have been investigated in several studies. We aimed to explore the vascular changes from acute NAION (aNAION) to chronic NAION (cNAION).
METHODS
This prospective observational study composed of 16 eyes with aNAION and 40 healthy age-matched controls. Eyes with NAION were followed up for more than 6 months after acute event. Optical coherence tomography angiography (OCTA) was used to evaluate peripapillary and macular vessel densities (VDs). The customized software was used for calculating deep retinal VD to attenuate the large superficial vessel projection effect.
RESULT
The mean age of patients with NAION and controls was 56.13 ± 13.2 and 54.46 ± 15.5 years, respectively (P = 0.195). Radial peripapillary capillary density was significantly lower in both eyes with aNAION and eyes with cNAION than healthy eyes. Peripapillary capillary density decreased significantly from the acute to the chronic phase of NAION with values of 41.77 ± 4.05% and 34.35 ± 7.30%, respectively (P < 0.001). The mean superficial macular VD was 46.83 ± 3.47% in aNAION and 44.49 ± 4.50% in cNAION eyes with no significant difference between them (P = 0.252), but both were lower than control eyes. Deep macular VD was not affected in aNAION and cNAION eyes compared with control eyes. Correlation analysis in eyes with cNAION revealed that there were significant correlations between peripapillary nerve fiber layer and the capillary density (r = 0.772, P < 0.001) and between ganglion cell complex thickness and corresponding superficial macular VD.
CONCLUSIONS
Although a decrease in peripapillary capillary density in aNAION eyes with active disc edema progressed when evaluated in the cNAION state, progressive VD loss was not observed in the macular area, suggesting a nonprogressive nature of macular vessel involvement in NAION.
Identifiants
pubmed: 34788242
doi: 10.1097/WNO.0000000000000997
pii: 00041327-202112000-00022
doi:
Types de publication
Journal Article
Observational Study
Langues
eng
Sous-ensembles de citation
IM
Pagination
e433-e439Informations de copyright
Copyright © 2020 by North American Neuro-Ophthalmology Society.
Déclaration de conflit d'intérêts
The authors report no conflicts of interest.
Références
Berry S, Lin WV, Sadaka A, Lee AG. Nonarteritic anterior ischemic optic neuropathy: cause, effect, and management. Eye Brain. 2017;9:23–28.
Newman NJ. The ischemic optic neuropathy decompression trial. JAMA Ophthalmol. 2007;125:1568–1570.
Patel HR, Margo CE. Pathology of ischemic optic neuropathy. Arch Pathol Lab Med. 2017;141:162–166.
Wright Mayes E, Cole ED, Dang S, Novais EA, Vuong L, Mendoza-Santiesteban C, Duker JS, Hedges TRI. Optical coherence tomography angiography in nonarteritic anterior ischemic optic neuropathy. J Neuroophthalmol. 2017;37:358–364.
Hata M, Oishi A, Muraoka Y, Miyamoto K, Kawai K, Yokota S, Fujimoto M, Miyata M, Yoshimura N. Structural and functional analyses in nonarteritic anterior ischemic optic neuropathy: optical coherence tomography angiography study. J Neuroophthalmol. 2017;37:140–148.
Higashiyama T, Ichiyama Y, Muraki S, Nishida Y, Ohji M. Optical coherence tomography angiography in a patient with optic atrophy after non-arteritic anterior ischaemic optic neuropathy. Neuroophthalmology. 2016;40:146–149.
Ling JW, Yin X, Lu QY, Chen YY, Lu PR. Optical coherence tomography angiography of optic disc perfusion in non-arteritic anterior ischemic optic neuropathy. Int J Ophthalmol. 2017;10:1402–1406.
Rougier MB, Delyfer MN, Korobelnik JF. OCT angiography of acute non-arteritic anterior ischemic optic neuropathy. J Fr Ophtalmol. 2017;40:102–109.
Sharma S, Ang M, Najjar RP, Sng C, Cheung CY, Rukmini AV, Schmetterer L, Milea D. Optical coherence tomography angiography in acute non-arteritic anterior ischaemic optic neuropathy. Br J Ophthalmol. 2017;101:1045–1051.
Augstburger E, Zeboulon P, Keilani C, Baudouin C, Labbe A. Retinal and choroidal microvasculature in nonarteritic anterior ischemic optic neuropathy: an optical coherence tomography angiography study. Invest Ophthalmol Vis Sci. 2018;59:870–877.
Liu CH, Wu WC, Sun MH, Kao LY, Lee YS, Chen HSL. Comparison of the retinal microvascular density between open angle glaucoma and nonarteritic anterior ischemic optic Neuropathy Retinal microvascular density in NAION and OAG. Invest Ophthalmol Vis Sci. 2017;58:3350–3356.
Fard MA, Ghahvechian H, Sahrayan A, Subramanian PS. Early macular vessel density loss in acute ischemic optic neuropathy compared to papilledema: implications for pathogenesis. Transl Vis Sci Technol. 2018;7:10.
Rebolleda G, Diez-Alvarez L, Garcia Marin Y, de Juan V, Munoz-Negrete FJ. Reduction of peripapillary vessel density by optical coherence tomography angiography from the acute to the atrophic stage in non-arteritic anterior ischaemic optic neuropathy. Ophthalmologica. 2018;240:191–199.
Spaide RF, Klancnik JM Jr, Cooney MJ. Retinal vascular layers imaged by fluorescein angiography and optical coherence tomography angiography. JAMA Ophthalmol. 2015;133:45–50.
Lavia C, Bonnin S, Maule M, Erginay A, Tadayoni R, Gaudric A. Vessel density of superficial intermediate, and deep capillary plexuses using optical coherence tomography angiography. Retina. 2019;39:247–258.
Fard MA, Jalili J, Sahraiyan A, Khojasteh H, Hejazi M, Ritch R, Subramanian PS. Optical coherence tomography angiography in optic disc swelling. Am J Ophthalmol. 2018;191:116–123.
Fard MA, Suwan Y, Moghimi S, Geyman LS, Chui TY, Rosen RB, Ritch R. Pattern of peripapillary capillary density loss in ischemic optic neuropathy compared to that in primary open-angle glaucoma. PLoS One. 2018;13:e0189237.
Song Y, Min Jy, Mao L, Gong Yy. Microvasculature dropout detected by the optical coherence tomography angiography in nonarteritic anterior ischemic optic neuropathy. Lasers Surg Med. 2018;50:194–201.
Gaier ED, Wang M, Gilbert AL, Rizzo JF III, Cestari DM, Miller JB. Quantitative analysis of optical coherence tomographic angiography (OCT-A) in patients with non-arteritic anterior ischemic optic neuropathy (NAION) corresponds to visual function. PLoS One. 2018;13:e0199793.
Jia Y, Simonett JM, Wang J, Hua X, Liu L, Hwang TS, Huang D. Wide-field OCT angiography investigation of the relationship between radial peripapillary capillary plexus density and nerve fiber layer thickness. Invest Ophthalmol Vis Sci. 2017;58:5188–5194.
Fard MA, Fakhraee G, Ghahvechian H, Sahraian A, Moghimi S, Ritch R. Macular vascularity in ischemic optic neuropathy compared to glaucoma by projection-resolved optical coherence tomography angiography. Am J Ophthalmol. 2020;209:27–34.