Ileitis-associated tertiary lymphoid organs arise at lymphatic valves and impede mesenteric lymph flow in response to tumor necrosis factor.

Animals Cell Movement Cells, Cultured Crohn Disease / immunology Disease Models, Animal Endothelial Cells / immunology Humans Ileitis Ileum / immunology Lymph / metabolism Lymphangitis Lymphatic Vessels / immunology Mesentery / immunology Mice Mice, Knockout Stress, Mechanical Tertiary Lymphoid Structures / immunology Tumor Necrosis Factor-alpha / metabolism
Crohn’s disease cytokine signaling endothelium inflammation inflammatory bowel disease lympho-organogenesis lymphocyte migration

Journal

Immunity
ISSN: 1097-4180
Titre abrégé: Immunity
Pays: United States
ID NLM: 9432918

Informations de publication

Date de publication:
14 12 2021
Historique:
received: 21 12 2020
revised: 09 08 2021
accepted: 05 10 2021
pubmed: 18 11 2021
medline: 19 2 2022
entrez: 17 11 2021
Statut: ppublish

Résumé

Lymphangitis and the formation of tertiary lymphoid organs (TLOs) in the mesentery are features of Crohn's disease. Here, we examined the genesis of these TLOs and their impact on disease progression. Whole-mount and intravital imaging of the ileum and ileum-draining collecting lymphatic vessels (CLVs) draining to mesenteric lymph nodes from TNF

Identifiants

DOI: 10.1016/j.immuni.2021.10.003 PMID: 34788601 PMC: PMC8678349
pubmed: 34788601
pii: S1074-7613(21)00409-X
doi: 10.1016/j.immuni.2021.10.003
pmc: PMC8678349
mid: NIHMS1749095
pii:
doi:

Substances chimiques

Tumor Necrosis Factor-alpha 0

Types de publication

Journal Article Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

2795-2811.e9

Subventions

Organisme : NHLBI NIH HHS
ID : R01 HL142905
Pays : United States
Organisme : NIAID NIH HHS
ID : R37 AI049653
Pays : United States
Organisme : NIDDK NIH HHS
ID : T32 DK077653
Pays : United States
Organisme : NIDDK NIH HHS
ID : P30 DK097948
Pays : United States
Organisme : NIDDK NIH HHS
ID : DP1 DK109668
Pays : United States
Organisme : NIAID NIH HHS
ID : T32 AI007163
Pays : United States
Organisme : NHLBI NIH HHS
ID : R01 HL145397
Pays : United States
Organisme : NIDDK NIH HHS
ID : P30 DK052574
Pays : United States
Organisme : NIDDK NIH HHS
ID : DP1 DK126190
Pays : United States
Organisme : NIDDK NIH HHS
ID : R01 DK119147
Pays : United States

Informations de copyright

Copyright © 2021 Elsevier Inc. All rights reserved.

Déclaration de conflit d'intérêts

Declaration of interests The authors declare no competing interests.

Références

Nat Genet. 2005 Oct;37(10):1072-81
pubmed: 16170315
JCI Insight. 2019 Mar 7;4(5):
pubmed: 30676326
EMBO Rep. 2005 Mar;6(3):233-8
pubmed: 15731765
Immunity. 2008 Sep 19;29(3):362-71
pubmed: 18799144
Gastroenterology. 2015 Apr;148(4):783-793.e5
pubmed: 25620669
Cell. 1999 Sep 17;98(6):769-78
pubmed: 10499794
Circ Res. 2018 Sep 28;123(8):964-985
pubmed: 30355030
Nature. 2019 May;569(7754):126-130
pubmed: 30988509
Gut. 2016 Feb;65(2):225-37
pubmed: 25887379
J Clin Invest. 2015 Oct 1;125(10):3861-77
pubmed: 26389677
J Crohns Colitis. 2018 Nov 9;12(10):1139-1150
pubmed: 29309546
Proc Natl Acad Sci U S A. 2020 Jul 21;117(29):17166-17176
pubmed: 32632016
Nat Commun. 2015 Jun 01;6:7274
pubmed: 26027726
Cell Rep. 2016 Sep 27;17(1):206-220
pubmed: 27681432
Cell. 2020 Jul 23;182(2):270-296
pubmed: 32707093
Gut. 2013 Jan;62(1):53-62
pubmed: 22267601
Am J Physiol Heart Circ Physiol. 2012 Oct 1;303(7):H795-808
pubmed: 22886407
Nature. 2011 Sep 21;478(7368):250-4
pubmed: 21937990
J Exp Med. 2002 Dec 16;196(12):1563-74
pubmed: 12486099
Nat Rev Gastroenterol Hepatol. 2020 Dec;17(12):740-754
pubmed: 32901108
Inflamm Bowel Dis. 2018 May 18;24(6):1298-1306
pubmed: 29688413
J Comp Pathol. 1997 Apr;116(3):217-61
pubmed: 9147244
Nature. 2008 Nov 27;456(7221):507-10
pubmed: 18987631
Mucosal Immunol. 2021 Jul 27;:
pubmed: 34316007
Lymphat Res Biol. 2014 Sep;12(3):124-35
pubmed: 25229432
Physiol Rev. 1990 Oct;70(4):987-1028
pubmed: 2217560
J Exp Med. 2018 Nov 5;215(11):2760-2777
pubmed: 30355615
Aliment Pharmacol Ther. 2011 Sep;34(5):533-43
pubmed: 21736598
Gastroenterology. 2011 Nov;141(5):1821-31
pubmed: 22027263
J Clin Invest. 2021 Jul 15;131(14):
pubmed: 34263740
Genes Dev. 2007 Oct 1;21(19):2422-32
pubmed: 17908929
Lancet. 2015 Nov 7;386(10006):1825-34
pubmed: 26342731
Am J Pathol. 2019 Oct;189(10):1953-1972
pubmed: 31547920
Eur J Immunol. 2002 Apr;32(4):1109-13
pubmed: 11920578
J Exp Med. 2000 Feb 7;191(3):435-44
pubmed: 10662789
Antioxid Redox Signal. 2016 Sep 1;25(7):451-65
pubmed: 27099026
Nature. 2010 Jan 28;463(7280):540-4
pubmed: 20023630
APMIS. 2014 Nov;122(11):1125-9
pubmed: 24730532
Nature. 2020 Feb;578(7796):527-539
pubmed: 32103191
J Clin Invest. 2015 Aug 3;125(8):2979-94
pubmed: 26214525
Sci Rep. 2014 Oct 17;4:6664
pubmed: 25322934
Gut. 2008 Jan;57(1):1-4
pubmed: 18094195
Lymphat Res Biol. 2009;7(2):87-96
pubmed: 19534632
J Cell Biol. 2009 May 4;185(3):439-57
pubmed: 19398761
Science. 2020 Jul 10;369(6500):
pubmed: 32646971
Lymphat Res Biol. 2015 Dec;13(4):234-47
pubmed: 26683026
Dev Cell. 2012 Feb 14;22(2):430-45
pubmed: 22306086
Blood. 2012 Feb 2;119(5):1283-91
pubmed: 22147895
Gut. 2017 Dec;66(12):2179-2187
pubmed: 28874419
Inflamm Bowel Dis. 2019 Feb 21;25(3):421-426
pubmed: 30346528
Mucosal Immunol. 2016 May;9(3):787-97
pubmed: 26487367
J Am Med Assoc. 1954 Nov 27;156(13):1221-5
pubmed: 13211222
Aliment Pharmacol Ther. 2011 Apr;33(8):930-9
pubmed: 21366631
J Crohns Colitis. 2011 Jun;5(3):203-10
pubmed: 21575882
Mucosal Immunol. 2016 Mar;9(2):468-78
pubmed: 26329428
Lancet. 2017 Apr 29;389(10080):1741-1755
pubmed: 27914655
Nat Metab. 2021 Sep;3(9):1175-1188
pubmed: 34545251
J Immunol. 1989 Jun 1;142(11):3884-93
pubmed: 2469726
Trends Mol Med. 2020 Nov;26(11):1021-1033
pubmed: 32600794
J Am Med Assoc. 1954 Jan 16;154(3):189-93
pubmed: 13108691
Nat Immunol. 2015 Aug;16(8):819-828
pubmed: 26147686
J Clin Invest. 2019 Apr 4;129(6):2514-2526
pubmed: 30946031
Science. 2015 Jan 16;347(6219):266-9
pubmed: 25431490
Am J Pathol. 2016 Dec;186(12):3066-3073
pubmed: 27746181
Immunity. 1999 Mar;10(3):387-98
pubmed: 10204494
J Exp Med. 2011 Jan 17;208(1):125-34
pubmed: 21173107
Am J Pathol. 2017 Apr;187(4):798-807
pubmed: 28183530
Front Immunol. 2016 Aug 16;7:308
pubmed: 27579025
Cell. 2020 Oct 29;183(3):666-683.e17
pubmed: 32991841
Scand J Gastroenterol. 1976;11(4):353-62
pubmed: 935796
Cell. 2015 Oct 8;163(2):354-66
pubmed: 26451485
Immunity. 2019 Apr 16;50(4):992-1006
pubmed: 30995511
J Biol Chem. 2009 Jan 23;284(4):2275-84
pubmed: 19049962
Gastroenterology. 2020 Nov;159(5):1955-1957.e2
pubmed: 32681923
Cell Rep. 2019 Aug 27;28(9):2397-2412.e4
pubmed: 31461654
J Exp Med. 1997 May 5;185(9):1573-84
pubmed: 9151895
Mucosal Immunol. 2014 May;7(3):602-14
pubmed: 24129162
Genes Dev. 2016 Jun 15;30(12):1454-69
pubmed: 27313318
J Exp Med. 2006 Mar 20;203(3):519-27
pubmed: 16533884
J Physiol. 2016 Oct 15;594(20):5749-5768
pubmed: 27219461

Auteurs

Rafael S Czepielewski (RS)

Department of Pathology, Washington University School of Medicine, St. Louis, MO 63110, USA.

Emma C Erlich (EC)

Department of Pathology, Washington University School of Medicine, St. Louis, MO 63110, USA.

Emily J Onufer (EJ)

Department of Surgery, Washington University School of Medicine, St. Louis, MO 63110, USA.

Shannon Young (S)

Department of Medicine, Washington University School of Medicine, St. Louis, MO 63110, USA.

Brian T Saunders (BT)

Department of Pathology, Washington University School of Medicine, St. Louis, MO 63110, USA.

Yong-Hyun Han (YH)

Department of Pathology, Washington University School of Medicine, St. Louis, MO 63110, USA.

Mary Wohltmann (M)

Department of Pathology, Washington University School of Medicine, St. Louis, MO 63110, USA.

Peter L Wang (PL)

Department of Pathology, Washington University School of Medicine, St. Louis, MO 63110, USA.

Ki-Wook Kim (KW)

Department of Pathology, Washington University School of Medicine, St. Louis, MO 63110, USA.

Shashi Kumar (S)

Department of Pathology, Washington University School of Medicine, St. Louis, MO 63110, USA.

Chyi-Song Hsieh (CS)

Department of Medicine, Washington University School of Medicine, St. Louis, MO 63110, USA.

Joshua P Scallan (JP)

Department of Molecular Pharmacology and Physiology, University of South Florida, Tampa, FL 33612, USA.

Ying Yang (Y)

Department of Molecular Pharmacology and Physiology, University of South Florida, Tampa, FL 33612, USA.

Bernd H Zinselmeyer (BH)

Department of Pathology, Washington University School of Medicine, St. Louis, MO 63110, USA.

Michael J Davis (MJ)

Department of Medical Pharmacology and Physiology, University of Missouri, Columbia, MO 65212, USA.

Gwendalyn J Randolph (GJ)

Department of Pathology, Washington University School of Medicine, St. Louis, MO 63110, USA. Electronic address: gjrandolph@wustl.edu.

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Ileitis-associated tertiary lymphoid organs...
questionsmedicales.fr › Phénomènes physiologiques › Mouvement cellulaire › Ileitis-associated tertiary lymphoid organs...
questionsmedicales.fr › Cellules › Cellules cultivées › Ileitis-associated tertiary lymphoid organs...
questionsmedicales.fr › Maladies de l'appareil digestif › Maladies gastro-intestinales › Maladies intestinales › Maladies inflammatoires intestinales › Maladie de Crohn › Ileitis-associated tertiary lymphoid organs...
questionsmedicales.fr › Techniques d'investigation › Modèles théoriques › Modèles biologiques › Modèles animaux de maladie humaine › Ileitis-associated tertiary lymphoid organs...
questionsmedicales.fr › Cellules › Cellules épithéliales › Cellules endothéliales › Ileitis-associated tertiary lymphoid organs...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Ileitis-associated tertiary lymphoid organs...
questionsmedicales.fr › Maladies de l'appareil digestif › Maladies gastro-intestinales › Maladies intestinales › Maladies de l'iléon › Iléite › Ileitis-associated tertiary lymphoid organs...
questionsmedicales.fr › Système digestif › Tube digestif › Tube digestif inférieur › Iléum › Ileitis-associated tertiary lymphoid organs...
questionsmedicales.fr › Systèmes sanguin et immunitaire › Système immunitaire › Système lymphatique › Lymphe › Ileitis-associated tertiary lymphoid organs...
questionsmedicales.fr › Hémopathies et maladies lymphatiques › Maladies lymphatiques › Lymphangite › Ileitis-associated tertiary lymphoid organs...
questionsmedicales.fr › Systèmes sanguin et immunitaire › Système immunitaire › Système lymphatique › Vaisseaux lymphatiques › Ileitis-associated tertiary lymphoid organs...
questionsmedicales.fr › Régions du corps › Tronc › Abdomen › Cavité abdominale › Mésentère › Ileitis-associated tertiary lymphoid organs...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Ileitis-associated tertiary lymphoid organs...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Souris transgéniques › Souris knockout › Ileitis-associated tertiary lymphoid organs...
questionsmedicales.fr › Phénomènes physiques › Phénomènes mécaniques › Contrainte mécanique › Ileitis-associated tertiary lymphoid organs...
questionsmedicales.fr › États, signes et symptômes pathologiques › États anatomopathologiques › Structures lymphoïdes tertiaires › Ileitis-associated tertiary lymphoid organs...
questionsmedicales.fr › Facteurs biologiques › Protéines et peptides de signalisation intercellulaire › Cytokines › Facteurs de nécrose tumorale › Facteur de nécrose tumorale alpha › Ileitis-associated tertiary lymphoid organs...