Essential role of TOSO/FAIM3 in intestinal IgM reverse transcytosis.
Animals
Apoptosis Regulatory Proteins
/ metabolism
Female
Immunity, Mucosal
/ physiology
Immunoglobulin A, Secretory
/ metabolism
Immunoglobulin M
/ immunology
Intestinal Mucosa
/ metabolism
Intestines
/ immunology
Membrane Proteins
/ metabolism
Mice
Mice, Inbred BALB C
Peyer's Patches
/ cytology
Transcytosis
/ genetics
IgM
TOSO/FAIM3
microfold cell
reverse transcytosis
Journal
Cell reports
ISSN: 2211-1247
Titre abrégé: Cell Rep
Pays: United States
ID NLM: 101573691
Informations de publication
Date de publication:
16 11 2021
16 11 2021
Historique:
received:
19
05
2020
revised:
17
05
2021
accepted:
26
10
2021
entrez:
17
11
2021
pubmed:
18
11
2021
medline:
15
2
2022
Statut:
ppublish
Résumé
Secretory immunoglobulin A (SIgA) can travel to and from the lumen and transport antigen to subepithelial cells. However, IgM can also multimerize into functional secretory component-bound immunoglobulin. While it is already known that both SIgA and SIgM undergo transcytosis to be secreted at the mucosal surface, only SIgA has been shown to perform retrotranscytosis through microfold cells (M cells) of the Peyer's patch. Here, we investigate whether SIgM could also be taken up by M cells via retrotranscytosis. This transport involves FcμR binding at the apical membrane of M cells. We then demonstrate that SIgM can be exploited by SIgM-p24 (HIV-capsid protein) complexes during immunization in the nasal- or gut-associated lymphoid tissue (NALT or GALT), conferring efficient immune responses against p24. Our data demonstrate a mucosal function of SIgM, which could play a role in the regulation of mucosal immunity.
Identifiants
pubmed: 34788614
pii: S2211-1247(21)01484-4
doi: 10.1016/j.celrep.2021.110006
pii:
doi:
Substances chimiques
Apoptosis Regulatory Proteins
0
Faim protein, mouse
0
Fcmr protein, mouse
0
Immunoglobulin A, Secretory
0
Immunoglobulin M
0
Membrane Proteins
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
110006Informations de copyright
Copyright © 2021 The Author(s). Published by Elsevier Inc. All rights reserved.
Déclaration de conflit d'intérêts
Declaration of interests The authors declare no competing interests.