Organoid Sensitivity Correlates with Therapeutic Response in Patients with Pancreatic Cancer.
Journal
Clinical cancer research : an official journal of the American Association for Cancer Research
ISSN: 1557-3265
Titre abrégé: Clin Cancer Res
Pays: United States
ID NLM: 9502500
Informations de publication
Date de publication:
15 02 2022
15 02 2022
Historique:
received:
22
10
2020
revised:
16
09
2021
accepted:
11
11
2021
pubmed:
19
11
2021
medline:
8
4
2022
entrez:
18
11
2021
Statut:
ppublish
Résumé
Pancreatic ductal adenocarcinoma (PDAC) remains a significant health issue. For most patients, there are no options for targeted therapy, and existing treatments are limited by toxicity. The HOPE trial (Harnessing Organoids for PErsonalized Therapy) was a pilot feasibility trial aiming to prospectively generate patient-derived organoids (PDO) from patients with PDAC and test their drug sensitivity and correlation with clinical outcomes. PDOs were established from a heterogeneous population of patients with PDAC including both basal and classical PDAC subtypes. A method for classifying PDOs as sensitive or resistant to chemotherapy regimens was developed to predict the clinical outcome of patients. Drug sensitivity testing on PDOs correlated with clinical responses to treatment in individual patients. These data support the investigation of PDOs to guide treatment in prospective interventional trials in PDAC.
Identifiants
pubmed: 34789479
pii: 1078-0432.CCR-20-4116
doi: 10.1158/1078-0432.CCR-20-4116
pmc: PMC8866201
mid: NIHMS1771723
doi:
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
708-718Subventions
Organisme : NCI NIH HHS
ID : K08 CA248473
Pays : United States
Organisme : NCATS NIH HHS
ID : UL1 TR002541
Pays : United States
Organisme : Judy and Kim Davis.
ID : ERC-2014-ADG-670582
Informations de copyright
©2021 American Association for Cancer Research.
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