Volumetric MRI is a promising outcome measure of muscle reinnervation.
Adult
Aged
Case-Control Studies
Elbow Joint
/ innervation
Electromyography
/ methods
Female
Humans
Magnetic Resonance Imaging
/ methods
Male
Middle Aged
Muscle Contraction
/ physiology
Muscle Fatigue
/ physiology
Muscle, Skeletal
/ innervation
Nerve Regeneration
/ physiology
Nerve Transfer
/ methods
Outcome Assessment, Health Care
/ methods
Peripheral Nerve Injuries
/ surgery
Prospective Studies
Recovery of Function
/ physiology
Reproducibility of Results
Retrospective Studies
Treatment Outcome
Young Adult
Journal
Scientific reports
ISSN: 2045-2322
Titre abrégé: Sci Rep
Pays: England
ID NLM: 101563288
Informations de publication
Date de publication:
17 11 2021
17 11 2021
Historique:
received:
08
02
2021
accepted:
18
10
2021
entrez:
18
11
2021
pubmed:
19
11
2021
medline:
29
1
2022
Statut:
epublish
Résumé
The development of outcome measures that can track the recovery of reinnervated muscle would benefit the clinical investigation of new therapies which hope to enhance peripheral nerve repair. The primary objective of this study was to assess the validity of volumetric Magnetic Resonance Imaging (MRI) as an outcome measure of muscle reinnervation by testing its reproducibility, responsiveness and relationship with clinical indices of muscular function. Over a 3-year period 25 patients who underwent nerve transfer to reinnervate elbow flexor muscles were assessed using intramuscular electromyography (EMG) and MRI (median post-operative assessment time of 258 days, ranging from 86 days pre-operatively to 1698 days post- operatively). Muscle power (Medical Research Council (MRC) grade) and Stanmore Percentage of Normal Elbow Assessment (SPONEA) assessment was also recorded for all patients. Sub-analysis of peak volitional force (PVF), muscular fatigue and co-contraction was performed in those patients with MRC > 3. The responsiveness of each parameter was compared using Pearson or Spearman correlation. A Hierarchical Gaussian Process (HGP) was implemented to determine the ability of volumetric MRI measurements to predict the recovery of muscular function. Reinnervated muscle volume per unit Body Mass Index (BMI) demonstrated good responsiveness (R
Identifiants
pubmed: 34789795
doi: 10.1038/s41598-021-01342-y
pii: 10.1038/s41598-021-01342-y
pmc: PMC8599480
doi:
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Validation Study
Langues
eng
Sous-ensembles de citation
IM
Pagination
22433Commentaires et corrections
Type : ErratumIn
Informations de copyright
© 2021. The Author(s).
Références
BMC Neurosci. 2014 Sep 13;15:107
pubmed: 25216784
Rev Esp Cir Ortop Traumatol. 2015 Jul-Aug;59(4):266-74
pubmed: 25572819
IEEE Trans Biomed Eng. 2006 Jul;53(7):1309-16
pubmed: 16830935
J Neurophysiol. 2003 May;89(5):2396-405
pubmed: 12611935
PLoS One. 2012;7(3):e33622
pubmed: 22428074
Ann Anat. 2011 Jul;193(4):321-33
pubmed: 21640570
J Hand Surg Am. 2007 Feb;32(2):149-53
pubmed: 17275586
Amyotroph Lateral Scler Frontotemporal Degener. 2013 Apr;14(3):217-23
pubmed: 23134509
Brain Res. 2020 Feb 15;1729:146625
pubmed: 31899213
Exp Brain Res. 2001 Sep;140(2):171-81
pubmed: 11521149
Scand J Trauma Resusc Emerg Med. 2018 Sep 10;26(1):76
pubmed: 30201025
Neural Regen Res. 2014 Oct 15;9(20):1796-809
pubmed: 25422641
J Bone Joint Surg Am. 2006 Jan;88(1):113-20
pubmed: 16391256
Clin Neurophysiol. 2018 Aug;129(8):1507-1516
pubmed: 29804042
BMJ. 2015 Jan 12;350:h121
pubmed: 25583733
Clin Neurophysiol. 2008 Sep;119(9):1951-65
pubmed: 18482862
J Hand Surg Br. 1996 Feb;21(1):4-13
pubmed: 8676027
Sci Rep. 2019 Feb 28;9(1):3117
pubmed: 30816300
Exp Neurol. 2004 Feb;185(2):254-61
pubmed: 14736506
J Emerg Trauma Shock. 2014 Oct;7(4):256-60
pubmed: 25400385
Exp Physiol. 2009 Jun;94(6):731-8
pubmed: 19251983
Lancet Neurol. 2016 Jan;15(1):65-77
pubmed: 26549782
J Biomech. 2012 Jan 10;45(2):334-41
pubmed: 22047782
Acta Neuropathol Commun. 2020 Apr 17;8(1):51
pubmed: 32303273
J Bone Joint Surg Am. 2000 Jan;82(1):16-25
pubmed: 10653080
J Hand Surg Am. 2010 Feb;35(2):332-41
pubmed: 20141906
Exp Brain Res. 2008 Feb;185(1):151-6
pubmed: 18205000
Bone Joint J. 2019 Jul;101-B(7):867-871
pubmed: 31256676
Am J Sports Med. 1999 Mar-Apr;27(2):214-21
pubmed: 10102104
Muscle Nerve. 2020 May;61(5):600-607
pubmed: 32022288
Neurosurgery. 2021 Jun 15;89(1):22-30
pubmed: 33694366
Bone Joint J. 2016 Nov;98-B(11):1517-1520
pubmed: 27803228
J Hand Surg Eur Vol. 2020 Oct;45(8):818-826
pubmed: 32380918
Neurosurgery. 1997 Jun;40(6):1182-8; discussion 1188-9
pubmed: 9179891
Public Health Nutr. 2019 Oct;22(14):2548-2552
pubmed: 31084660
J Neurol Neurosurg Psychiatry. 2018 Mar;89(3):248-255
pubmed: 29089397
J Electromyogr Kinesiol. 2012 Aug;22(4):501-12
pubmed: 22440555
BMJ. 2015 Feb 10;350:g7818
pubmed: 25670183
Eur J Appl Physiol. 2011 Jun;111(6):1063-71
pubmed: 21113614
Arch Neurol Psychiatry. 1947 Sep;58(3):251-95
pubmed: 20265595
Clin Orthop Relat Res. 1997 Jan;(334):144-9
pubmed: 9005907
J Plast Reconstr Aesthet Surg. 2020 Feb;73(2):201-208
pubmed: 31831264
Plast Reconstr Surg. 2016 Jun;137(6):1771-1780
pubmed: 26890510
PLoS One. 2016 Aug 05;11(8):e0160480
pubmed: 27494612
Curr Tissue Microenviron Rep. 2020;1(2):49-59
pubmed: 33381765
Int J Shoulder Surg. 2012 Jan;6(1):9-14
pubmed: 22518074
Front Cell Neurosci. 2019 Feb 11;13:33
pubmed: 30804758
Ulus Travma Acil Cerrahi Derg. 2011 Nov;17(6):539-44
pubmed: 22290008
Exp Neurol. 2003 Dec;184(2):753-7
pubmed: 14769367
Bone Joint J. 2019 Feb;101-B(2):124-131
pubmed: 30700118