Luteolin Modulates Neural Stem Cells Fate Determination:
AICAR
LPS-induced depression model
NSCs isolation
astrocyte isolation
astrogenesis
human neural stem cells
luteolin
stem cell differentiation
Journal
Frontiers in cell and developmental biology
ISSN: 2296-634X
Titre abrégé: Front Cell Dev Biol
Pays: Switzerland
ID NLM: 101630250
Informations de publication
Date de publication:
2021
2021
Historique:
received:
04
08
2021
accepted:
11
10
2021
entrez:
18
11
2021
pubmed:
19
11
2021
medline:
19
11
2021
Statut:
epublish
Résumé
Luteolin is a natural flavone with neurotrophic effects observed on different neuronal cell lines. In the present study, we aimed to assess the effect of luteolin on hNSCs fate determination and the LPS-induced neuroinflammation in a mouse model of depression with astrocytogenesis defect. hNSCs were cultured in basal cell culture medium (control) or medium supplemented with luteolin or AICAR, a known inducer of astrogenesis. A whole-genome transcriptomic analysis showed that luteolin upregulated the expressions of genes related to neurotrophin, dopaminergic, hippo, and Wnt signaling pathways, and downregulated the genes involved in p53, TNF, FOXO, and Notch signaling pathways. We also found that astrocyte-specific gene GFAP, as well as other genes of the key signaling pathways involved in astrogenesis such as Wnt, BMP, and JAK-STAT pathways were upregulated in luteolin-treated hNSCs. On the other hand, neurogenesis and oligodendrogenesis-related genes,
Identifiants
pubmed: 34790666
doi: 10.3389/fcell.2021.753279
pmc: PMC8591246
doi:
Types de publication
Journal Article
Langues
eng
Pagination
753279Informations de copyright
Copyright © 2021 Achour, Ferdousi, Sasaki and Isoda.
Déclaration de conflit d'intérêts
The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
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