Translational Aspects of the Immunology of Clostridioides difficile Infection: Implications for Pediatric Populations.
C. difficile
antibody
immunity
pediatric
vaccine
Journal
Journal of the Pediatric Infectious Diseases Society
ISSN: 2048-7207
Titre abrégé: J Pediatric Infect Dis Soc
Pays: England
ID NLM: 101586049
Informations de publication
Date de publication:
17 Nov 2021
17 Nov 2021
Historique:
entrez:
18
11
2021
pubmed:
19
11
2021
medline:
20
11
2021
Statut:
ppublish
Résumé
Clostridioides difficile has become the most common healthcare-associated pathogen in the United States, leading the US Centers for Disease Control and Prevention (CDC) to classify C. difficile as an "urgent" public health threat that requires "urgent and aggressive action." This call to action has led to new discoveries that have advanced our understanding of Clostridioides difficile infection (CDI) immunology and clinical development of immunologic-based therapies for CDI prevention. However, CDI immunology research has been limited in pediatric populations, and several unanswered questions remain regarding the function of host immune response in pediatric CDI pathogenesis and the potential role of immunologic-based therapies in children. This review summarizes the innate and adaptive immune responses previously characterized in animals and humans and provides a current update on clinical development of immunologic-based therapies for CDI prevention in adults and children. These data inform the future research needs for children.
Identifiants
pubmed: 34791392
pii: 6430221
doi: 10.1093/jpids/piab089
pmc: PMC8600028
doi:
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
S8-S15Subventions
Organisme : NIAID NIH HHS
ID : K22 AI137220
Pays : United States
Organisme : NIH HHS
ID : R03-AI149000
Pays : United States
Organisme : National Institute of Allergy and Infectious Diseases
Organisme : NIAID NIH HHS
ID : L40 AI147162
Pays : United States
Organisme : Texas Medical Center Digestive Disease Center
ID : P30-DK56338
Organisme : NIGMS NIH HHS
ID : R35 GM138369
Pays : United States
Organisme : NIGMS NIH HHS
ID : R35-GM138369
Pays : United States
Organisme : NIAID NIH HHS
ID : U01 AI124290
Pays : United States
Informations de copyright
© The Author(s) 2021. Published by Oxford University Press on behalf of The Journal of the Pediatric Infectious Diseases Society. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.
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