Allogeneic islet transplantation with monitoring of islet-specific cellular autoimmunity in a Japanese patient with type 1 diabetes: A case report.
Autoimmune response
Islet transplantation
Type 1 diabetes mellitus
Journal
Journal of diabetes investigation
ISSN: 2040-1124
Titre abrégé: J Diabetes Investig
Pays: Japan
ID NLM: 101520702
Informations de publication
Date de publication:
Apr 2022
Apr 2022
Historique:
revised:
01
11
2021
received:
01
09
2021
accepted:
16
11
2021
pubmed:
19
11
2021
medline:
22
4
2022
entrez:
18
11
2021
Statut:
ppublish
Résumé
Here, we report a case of allogeneic islet transplantation in Japan. A 48-year-old man received intraportal islet transplantation (5,945 islet equivalent/kg), and stabilization of blood glucose levels and suppression of hypoglycemia were achieved. In the present case, we used our original assessment method to detect the responses of the recipient's T cells to islet autoantigens over time to monitor cellular autoimmunity. Other markers could not predict graft dysfunction in advance, but our method detected the activation of islet antigen-specific CD8
Identifiants
pubmed: 34792297
doi: 10.1111/jdi.13715
pmc: PMC9017629
doi:
Types de publication
Case Reports
Langues
eng
Sous-ensembles de citation
IM
Pagination
741-745Subventions
Organisme : NCGM Intramural Research Fund
ID : 24A002
Informations de copyright
© 2021 The Authors. Journal of Diabetes Investigation published by Asian Association for the Study of Diabetes (AASD) and John Wiley & Sons Australia, Ltd.
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