Stratification of adolescents across mental phenomena emphasizes the importance of transdiagnostic distress: a replication in two general population cohorts.
Adolescence
Classification
Psychopathology
Transdiagnostic approach
Journal
European child & adolescent psychiatry
ISSN: 1435-165X
Titre abrégé: Eur Child Adolesc Psychiatry
Pays: Germany
ID NLM: 9212296
Informations de publication
Date de publication:
May 2023
May 2023
Historique:
received:
07
05
2021
accepted:
06
11
2021
medline:
1
5
2023
pubmed:
19
11
2021
entrez:
18
11
2021
Statut:
ppublish
Résumé
Characterizing patterns of mental phenomena in epidemiological studies of adolescents can provide insight into the latent organization of psychiatric disorders. This avoids the biases of chronicity and selection inherent in clinical samples, guides models of shared aetiology within psychiatric disorders and informs the development and implementation of interventions. We applied Gaussian mixture modelling to measures of mental phenomena from two general population cohorts: the Avon Longitudinal Study of Parents and Children (ALSPAC, n = 3018) and the Neuroscience in Psychiatry Network (NSPN, n = 2023). We defined classes according to their patterns of both positive (e.g. wellbeing and self-esteem) and negative (e.g. depression, anxiety, and psychotic experiences) phenomena. Subsequently, we characterized classes by considering the distribution of diagnoses and sex split across classes. Four well-separated classes were identified within each cohort. Classes primarily differed by overall severity of transdiagnostic distress rather than particular patterns of phenomena akin to diagnoses. Further, as overall severity of distress increased, so did within-class variability, the proportion of individuals with operational psychiatric diagnoses. These results suggest that classes of mental phenomena in the general population of adolescents may not be the same as those found in clinical samples. Classes differentiated only by overall severity support the existence of a general, transdiagnostic mental distress factor and have important implications for intervention.
Identifiants
pubmed: 34792650
doi: 10.1007/s00787-021-01909-0
pii: 10.1007/s00787-021-01909-0
pmc: PMC10147756
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
797-807Subventions
Organisme : Wellcome Trust
ID : 201486/Z/16/Z
Pays : United Kingdom
Organisme : MQ: Transforming Mental Health
ID : MQDS17/40
Pays : United Kingdom
Organisme : Medical Research Council
ID : MR/L010305/1
Pays : United Kingdom
Organisme : Wellcome Trust
ID : 209138/Z/17/Z
Pays : United Kingdom
Organisme : Medical Research Council
ID : MC_G0802534
Pays : United Kingdom
Organisme : Wellcome Trust
ID : 095844/Z/11/Z
Pays : United Kingdom
Organisme : Medical Research Council
ID : MR/L022206/1
Pays : United Kingdom
Organisme : Medical Research Council
ID : MC_PC_17213
Pays : United Kingdom
Informations de copyright
© 2021. The Author(s).
Références
J Child Psychol Psychiatry. 2000 Jul;41(5):645-55
pubmed: 10946756
Schizophr Bull. 2013 Jul;39(4):884-95
pubmed: 22258881
World Psychiatry. 2018 Jun;17(2):121-122
pubmed: 29856539
Br J Psychiatry. 2016 Aug;209(2):107-13
pubmed: 26989099
J Consult Clin Psychol. 2020 Mar;88(3):179-195
pubmed: 32068421
Br J Psychiatry. 2016 Aug;209(2):162-8
pubmed: 26635327
Health Qual Life Outcomes. 2007 Nov 27;5:63
pubmed: 18042300
J Am Acad Child Adolesc Psychiatry. 1988 Nov;27(6):726-37
pubmed: 3058677
Psychol Med. 2002 Feb;32(2):347-58
pubmed: 11866327
Perspect Psychol Sci. 2019 May;14(3):419-436
pubmed: 30844330
Aust N Z J Psychiatry. 2003 Dec;37(6):696-704
pubmed: 14636384
J Abnorm Child Psychol. 2016 Nov;44(8):1573-1586
pubmed: 26846993
Br J Psychiatry Suppl. 2013 Jan;54:s5-10
pubmed: 23288502
J Child Psychol Psychiatry. 1989 Nov;30(6):879-88
pubmed: 2592471
Br J Psychiatry. 2011 Nov;199(5):380-5
pubmed: 21947654
Psychol Med. 2015 May;45(7):1483-93
pubmed: 25394403
J Am Acad Child Adolesc Psychiatry. 2002 Oct;41(10):1246-52
pubmed: 12364847
JAMA Netw Open. 2020 Apr 1;3(4):e203221
pubmed: 32315069
Science. 1994 Jun 17;264(5166):1733-9
pubmed: 8209254
J Abnorm Child Psychol. 1978 Jun;6(2):271-80
pubmed: 670592
Behav Res Ther. 2006 Jun;44(6):849-60
pubmed: 16122697
R J. 2016 Aug;8(1):289-317
pubmed: 27818791
Compr Psychiatry. 2012 May;53(4):323-32
pubmed: 21757192
Psychol Med. 2009 Dec;39(12):1935-41
pubmed: 19368761
World Psychiatry. 2019 Jun;18(2):192-207
pubmed: 31059629
Clin Psychol Sci. 2014 Mar;2(2):119-137
pubmed: 25360393
Soc Psychiatry Psychiatr Epidemiol. 2015 Apr;50(4):515-24
pubmed: 25682108
Int J Epidemiol. 2013 Feb;42(1):111-27
pubmed: 22507743
Acta Psychiatr Scand. 2003 May;107(5):378-84
pubmed: 12752034
Annu Rev Clin Psychol. 2010;6:155-79
pubmed: 17716032
World Psychiatry. 2018 Jun;17(2):187-195
pubmed: 29856559
BMC Med. 2013 May 14;11:126
pubmed: 23672542
Mol Psychiatry. 2018 Mar;23(3):495-496
pubmed: 27821868
Int J Epidemiol. 2013 Feb;42(1):97-110
pubmed: 22507742
J Comput Graph Stat. 2010 Jun 1;9(2):332-353
pubmed: 20953302
J Psychiatr Res. 2013 Nov;47(11):1649-57
pubmed: 23978394
Arch Gen Psychiatry. 2005 Jun;62(6):593-602
pubmed: 15939837
J Forensic Sci. 2019 Jul;64(4):982-988
pubmed: 30695107
Transl Psychiatry. 2018 Aug 8;8(1):145
pubmed: 30089819
Int J Epidemiol. 2018 Feb 1;47(1):18-19g
pubmed: 29177462
Arch Gen Psychiatry. 2003 Jul;60(7):709-17
pubmed: 12860775