Antigenic evolution of dengue viruses over 20 years.
Journal
Science (New York, N.Y.)
ISSN: 1095-9203
Titre abrégé: Science
Pays: United States
ID NLM: 0404511
Informations de publication
Date de publication:
19 Nov 2021
19 Nov 2021
Historique:
entrez:
18
11
2021
pubmed:
19
11
2021
medline:
15
12
2021
Statut:
ppublish
Résumé
Infection with one of dengue viruses 1 to 4 (DENV1-4) induces protective antibodies against homotypic infection. However, a notable feature of dengue viruses is the ability to use preexisting heterotypic antibodies to infect Fcγ receptor–bearing immune cells, leading to higher viral load and immunopathological events that augment disease. We tracked the antigenic dynamics of each DENV serotype by using 1944 sequenced isolates from Bangkok, Thailand, between 1994 and 2014 (348 strains), in comparison with regional and global DENV antigenic diversity (64 strains). Over the course of 20 years, the Thailand DENV serotypes gradually evolved away from one another. However, for brief periods, the serotypes increased in similarity, with corresponding changes in epidemic magnitude. Antigenic evolution within a genotype involved a trade-off between two types of antigenic change (within-serotype and between-serotype), whereas genotype replacement resulted in antigenic change away from all serotypes. These findings provide insights into theorized dynamics in antigenic evolution.
Identifiants
pubmed: 34793238
doi: 10.1126/science.abk0058
pmc: PMC8693836
mid: NIHMS1759275
doi:
Substances chimiques
Antibodies, Viral
0
Antigens, Viral
0
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
999-1004Subventions
Organisme : NIAID NIH HHS
ID : R01 AI114703
Pays : United States
Commentaires et corrections
Type : CommentIn
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