Strategic Planning and Essential Steps for Establishing a Uterine Transplant and Rehabilitation Program: From Idea to Reality.
Journal
Annals of surgery
ISSN: 1528-1140
Titre abrégé: Ann Surg
Pays: United States
ID NLM: 0372354
Informations de publication
Date de publication:
01 07 2022
01 07 2022
Historique:
pubmed:
19
11
2021
medline:
14
7
2022
entrez:
18
11
2021
Statut:
ppublish
Résumé
UTx is performed to address absolute uterine infertility in the presence of uterine agenesis, a nonfunctional uterus, or after a prior hysterectomy. After the initial success of UTx resulting in a livebirth (2014) in Sweden, there are over 70 reported UTx surgeries resulting in more than 40 livebirths worldwide. Currently, UTx has been performed in over 10 countries. As UTx is transitioning from an "experimental procedure" to a clinical option, an increasing number of centers may contemplate a UTx program. This article discusses essential steps for establishment of a successful UTx program. These principles may be implemented in cis- and transgender UTx candidates.
Identifiants
pubmed: 34793341
doi: 10.1097/SLA.0000000000005301
pii: 00000658-202207000-00011
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
74-80Informations de copyright
Copyright © 2021 Wolters Kluwer Health, Inc. All rights reserved.
Déclaration de conflit d'intérêts
The authors report no conflicts of interest.
Références
Fageeh W, Raffa H, Jabbad H, et al. Transplantation of the human uterus. Int J Gynaecol Obstet 2002; 76:245–251.
Johannesson L, Kvarnström N, Mölne J, et al. Uterus transplantation trial: 1-year outcome. Fertil Steril 2015; 103:199–204.
Brännstrom M, Johannesson L, Bokstrom H, et al. Livebirth after uterus transplantation. Lancet 2015; 385:607–616.
Ozkan O, Akar ME, Ozkan O, et al. Preliminary results of the first human uterus transplantation from a multiorgan donor. Fertil Steril 2013; 99:470–476.
Huang Y, Ding X, Chen B, et al. Report of the first live birth after uterus transplantation in People's Republic of China. Fertil Steril 2020; 114:1108–1115.
Brucker SY, Strowitzki T, Taran FA, et al. Living-donor uterus transplantation: pre-, intra-, and postoperative parameters relevant to surgical success, pregnancy, and obstetrics with live births. J Clin Med 2020; 9:1–21.
Ejzenberg D, Andraus W, Baratelli Carelli Mendes LR, et al. Livebirth after uterus transplantation from a deceased donor in a recipient with uterine infertility. Lancet 2019; 392:2697–2704.
Ramani A, Testa G, Ghouri Y, et al. DUETS (Dallas UtErus Transplant Study): complete report of 6-month and initial 2-year outcomes following open donor hysterectomy. Clin Transplant 2020; 34:e13757.
Flyckt R, Davis A, Farrell R, et al. Uterine transplantation: surgical innovation in the treatment of uterine factor infertility. J Obstet Gynaecol Can 2018; 40:86–93.
Fronek J, Kristek J, Chlupac J, et al. Human uterus transplantation from living and deceased donors: the interim results of the first 10 cases of the Czech trial. J Clin Med 2021; 10:1–15.
Puntambekar S, Puntambekar S, Telang M, et al. Novel anastomotic technique for uterine transplant using utero-ovarian veins for venous drainage and internal iliac arteries for perfusion in two laparoscopically harvested uteri. J Minim Invasive Gynecol 2019; 26:628–635.
Jones BP, Kasaven L, Vali S, et al. Uterine transplantation; review of livebirths and reproductive implications. Transplantation 2020; 105:1695–1707.
Carmona F, Rius M, Díaz-Feijoo B, et al. Uterine transplantation. First viable case in Southern Europe. Med Clin (Barc) 2021; 156:297–300.
Johannesson L, Wall A, Tzakis A, et al. Life underneath the VCA umbrella: perspectives from the US uterus transplant consortium. Am J Transplant 2020; 21:1699–1704.
Siemionow M, Gordon CR. Overview of guidelines for establishing a face transplantprogram: aworkinprogress. Am JTransplant 2010; 10:1290–1296.
Gordon CR, Siemionow M. Requirements for the development of a hand transplantation program. Ann Plast Surg 2009; 63:262–273.
Jones BP, Williams NJ, Saso S, et al. Uterine transplantation in transgender women. BJOG 2019; 126:152–156.
Hamidian Jahromi A, Horen SR, Dorafshar AH, et al. Uterine transplantation and donation in transgender individuals; proof of concept. Int J Transgend Health 2021; 22:349–359.
Moore FD. Ethical problems special to surgery: surgical teaching, surgical innovation, and the surgeon in managed care. Arch Surg 2000; 135:14–16.
Testa G, McKenna GJ, Bayer J, et al. The evolution of transplantation from saving lives to fertility treatment: DUETS (Dallas UtErus Transplant Study). Ann Surg 2020; 272:411–417.
Alghrani A. Uterus transplantation: does procreative liberty encompass a right to gestate? J Law Biosci 2016; 3:636–641.
Alghrani A. Uterus transplantation in and beyond cisgender women: revisiting procreative liberty in light of emerging reproductive technologies. J Law Biosci 2018; 5:301–328.
Robertson JA. Is there a right to gestate? J Law Biosci 2017; 4:630–636.
Lefkowitz A, Edwards M, Balayla J. Ethical considerations in the era of the uterine transplant: an update of the Montreal Criteria for the ethical feasibility of uterine transplantation. Fertil Steril 2013; 100:924–926.
Mookerjee VG, Kwan D. Uterus transplantation as a fertility option in transgender healthcare. Int J Transgend Health 2019; 21:122–124.
Balayla J, Pounds P, Lasry A, et al. The Montreal Criteriaanduterine transplants in transgender women. Bioethics 2021; 35:326–330.
Murphy TF. Assisted gestation and transgender women. Bioethics 2015; 29:389–397.
Pomahac B. Establishing a composite tissue allotransplantation program. J Reconstr Microsurg 2012; 28:3–6.
Johannesson L, Testa G, Putman JM, et al. Twelve live births after uterus transplantation in the Dallas UtErus Transplant Study. Obstet Gynecol 2021; 137:241–249.
Manoucheri E, Cohen SL, Sandberg EM, et al. Ureteral injury in laparoscopic gynecologic surgery. Rev Obstet Gynecol 2012; 5:106–111.
Brucker SY, Brännström M, Taran FA, et al. Selecting living donors for uterus transplantation: lessons learned from two transplantations resulting in menstrual functionality and another attempt, aborted after organ retrieval. Arch Gynecol Obstet 2018; 297:675–684.
Brannstrom M, Johannesson L, Dahm-Kahler P, et al. First clinical uterus transplantation trial: a six-month report. Fertil Steril 2014; 101:1228–1236.
Hwang JH, Kim BW. Laparoscopic radical hysterectomy has higher risk of perioperative urologic complication than abdominal radical hysterectomy: a meta-analysis of 38 studies. Surg Endosc 2020; 34:1509–1521.
Kasaven LS, Jones BP, Keays R, et al. Anaesthetic considerations for fertility-sparing surgery and uterine transplantation. Anaesthesia 2021; 76: (Suppl 4): 46–55.
Jarvholm S, Warren AM, Jalmbrant M, et al. Preoperative psychological evaluation of uterus transplant recipients, partners, and living donors: suggested framework. Am J Transplant 2018; 18:2641–2646.
Siemionow MZ, Gordon CR. Institutional review board-based recommendations for medical institutions pursuing protocol approval for facial transplantation. Plast Reconstr Surg 2010; 126:1232–1239.
Davidson T, Ekberg J, Sandman L, et al. The costs of human uterus transplantation: a study based on the nine cases of the initial Swedish live donor trial. Hum Reprod 2021; 36:358–366.
Farrell RM, Johannesson L, Flyckt R, et al. Evolving ethical issues with advances in uterus transplantation. Am J Obstet Gynecol 2020; 222:584.e1–584.e5.
Nassir BA, Dean CE, Li S, et al. Variation in cost and quality in kidney transplantation. Transplantation 2015; 99:2150–2157.
Blake VK. Financing uterus transplants: the United States context. Bioethics 2018; 32:527–533.
Rahmel A. Vascularized composite allografts: procurement, allocation, and implementation. Curr Transplant Rep 2014; 1:173–182.