Transcutaneous spinal cord stimulation and motor responses in individuals with spinal cord injury: A methodological review.
Journal
PloS one
ISSN: 1932-6203
Titre abrégé: PLoS One
Pays: United States
ID NLM: 101285081
Informations de publication
Date de publication:
2021
2021
Historique:
received:
25
05
2021
accepted:
03
11
2021
entrez:
18
11
2021
pubmed:
19
11
2021
medline:
8
1
2022
Statut:
epublish
Résumé
Transcutaneous spinal cord stimulation (tSCS) is a non-invasive modality in which electrodes can stimulate spinal circuitries and facilitate a motor response. This review aimed to evaluate the methodology of studies using tSCS to generate motor activity in persons with spinal cord injury (SCI) and to appraise the quality of included trials. A systematic search for studies published until May 2021 was made of the following databases: EMBASE, Medline (Ovid) and Web of Science. Two reviewers independently screened the studies, extracted the data, and evaluated the quality of included trials. The electrical characteristics of stimulation were summarised to allow for comparison across studies. In addition, the surface electromyography (EMG) recording methods were evaluated. A total of 3753 articles were initially screened, of which 25 met the criteria for inclusion. Studies were divided into those using tSCS for neurophysiological investigations of reflex responses (n = 9) and therapeutic investigations of motor recovery (n = 16). The overall quality of evidence was deemed to be poor-to-fair (10.5 ± 4.9) based on the Downs and Black Quality Checklist criteria. The electrical characteristics were collated to establish the dosage range across stimulation trials. The methods employed by included studies relating to stimulation parameters and outcome measurement varied extensively, although some trends are beginning to appear in relation to electrode configuration and EMG outcomes. This review outlines the parameters currently employed for tSCS of the cervicothoracic and thoracolumbar regions to produce motor responses. However, to establish standardised procedures for neurophysiological assessments and therapeutic investigations of tSCS, further high-quality investigations are required, ideally utilizing consistent electrophysiological recording methods, and reporting common characteristics of the electrical stimulation administered.
Sections du résumé
BACKGROUND
Transcutaneous spinal cord stimulation (tSCS) is a non-invasive modality in which electrodes can stimulate spinal circuitries and facilitate a motor response. This review aimed to evaluate the methodology of studies using tSCS to generate motor activity in persons with spinal cord injury (SCI) and to appraise the quality of included trials.
METHODS
A systematic search for studies published until May 2021 was made of the following databases: EMBASE, Medline (Ovid) and Web of Science. Two reviewers independently screened the studies, extracted the data, and evaluated the quality of included trials. The electrical characteristics of stimulation were summarised to allow for comparison across studies. In addition, the surface electromyography (EMG) recording methods were evaluated.
RESULTS
A total of 3753 articles were initially screened, of which 25 met the criteria for inclusion. Studies were divided into those using tSCS for neurophysiological investigations of reflex responses (n = 9) and therapeutic investigations of motor recovery (n = 16). The overall quality of evidence was deemed to be poor-to-fair (10.5 ± 4.9) based on the Downs and Black Quality Checklist criteria. The electrical characteristics were collated to establish the dosage range across stimulation trials. The methods employed by included studies relating to stimulation parameters and outcome measurement varied extensively, although some trends are beginning to appear in relation to electrode configuration and EMG outcomes.
CONCLUSION
This review outlines the parameters currently employed for tSCS of the cervicothoracic and thoracolumbar regions to produce motor responses. However, to establish standardised procedures for neurophysiological assessments and therapeutic investigations of tSCS, further high-quality investigations are required, ideally utilizing consistent electrophysiological recording methods, and reporting common characteristics of the electrical stimulation administered.
Identifiants
pubmed: 34793572
doi: 10.1371/journal.pone.0260166
pii: PONE-D-21-17243
pmc: PMC8601579
doi:
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Systematic Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
e0260166Déclaration de conflit d'intérêts
The authors have declared that no competing interests exist.
Références
Artif Organs. 2015 Oct;39(10):E176-86
pubmed: 26450344
Front Cell Neurosci. 2019 Nov 12;13:512
pubmed: 31798419
NeuroRehabilitation. 2021;49(1):1-22
pubmed: 33967072
Artif Organs. 2015 Oct;39(10):834-40
pubmed: 26471133
PLoS One. 2018 Jan 30;13(1):e0192013
pubmed: 29381748
Top Spinal Cord Inj Rehabil. 2007 Summer;13(1):32-57
pubmed: 22915835
J Neurotrauma. 2015 Dec 15;32(24):1968-80
pubmed: 26077679
Neuroscience. 1997 Jan;76(1):39-54
pubmed: 8971757
Eur J Neurosci. 2001 Dec;14(11):1906-14
pubmed: 11860485
Health Technol Assess. 2003;7(27):iii-x, 1-173
pubmed: 14499048
Top Spinal Cord Inj Rehabil. 2007 Summer;13(1):1-10
pubmed: 22767989
J Neurophysiol. 2019 Nov 1;122(5):2111-2118
pubmed: 31553681
PLoS One. 2013 Oct 07;8(10):e76940
pubmed: 24282479
Biomed Tech (Berl). 2013 Sep 7;58 Suppl 1:
pubmed: 24042628
J Neural Eng. 2020 Feb 18;17(1):016064
pubmed: 31791027
Muscle Nerve. 1996 Aug;19(8):966-79
pubmed: 8756162
PLoS One. 2016 Feb 09;11(2):e0149024
pubmed: 26859296
Spinal Cord. 2012 Jun;50(6):432-9
pubmed: 22249322
Front Neuroeng. 2011 Sep 28;4:9
pubmed: 22007167
J Spinal Cord Med. 2014 Jul;37(4):401-13
pubmed: 24621020
J Neurophysiol. 2020 Jan 1;123(1):158-166
pubmed: 31747338
Spine (Phila Pa 1976). 1998 Jul 1;23(13):1452-6
pubmed: 9670396
J Clin Med. 2020 Aug 26;9(9):
pubmed: 32858977
J Neurophysiol. 2019 May 1;121(5):1672-1679
pubmed: 30840527
J Electromyogr Kinesiol. 2000 Oct;10(5):361-74
pubmed: 11018445
J Epidemiol Community Health. 1998 Jun;52(6):377-84
pubmed: 9764259
Clin Neurophysiol. 2020 Feb;131(2):451-460
pubmed: 31887616
Arch Phys Med Rehabil. 2002 Jul;83(7):1024-7
pubmed: 12098166
West J Nurs Res. 2003 Mar;25(2):223-37
pubmed: 12666645
Front Neurol. 2020 Dec 18;11:578559
pubmed: 33408680
J Neurophysiol. 2010 May;103(5):2808-20
pubmed: 20357075
Prog Neurobiol. 2018 Jan;160:64-81
pubmed: 29102670
Clin Neurophysiol. 2011 Oct;122(10):2071-80
pubmed: 21458371
J Clin Med. 2020 Nov 02;9(11):
pubmed: 33147884
Annu Int Conf IEEE Eng Med Biol Soc. 2017 Jul;2017:1114-1117
pubmed: 29060070
Nature. 2018 Nov;563(7729):65-71
pubmed: 30382197
Ann Phys Rehabil Med. 2015 Sep;58(4):225-231
pubmed: 26205686
J Sport Health Sci. 2020 Oct 14;:
pubmed: 33068748
IEEE Trans Neural Syst Rehabil Eng. 2021;29:310-319
pubmed: 33400652
Curr Pharm Des. 2017;23(12):1805-1820
pubmed: 27981912
IEEE Trans Neural Syst Rehabil Eng. 2018 Jun;26(6):1272-1278
pubmed: 29877852
Biomed Tech (Berl). 2013 Sep 7;58 Suppl 1:
pubmed: 24042607
Brain Sci. 2019 Nov 21;9(12):
pubmed: 31766487
Front Neurosci. 2020 Jun 22;14:552
pubmed: 32655351
Hum Mov Sci. 2007 Apr;26(2):275-95
pubmed: 17343947
Neurorehabil Neural Repair. 2020 Jan;34(1):3-12
pubmed: 31858871
Br J Anaesth. 2008 Dec;101(6):804-9
pubmed: 18936040
Neurosci Lett. 2016 Aug 3;627:100-6
pubmed: 27235576
IEEE Trans Neural Syst Rehabil Eng. 2006 Mar;14(1):14-23
pubmed: 16562627
Cell Transplant. 2015;24(3):429-46
pubmed: 25646771
Front Neurosci. 2017 Jun 08;11:333
pubmed: 28642680
PLoS One. 2019 Dec 26;14(12):e0227057
pubmed: 31877192
PLoS One. 2015 May 05;10(5):e0125609
pubmed: 25942010
Artif Organs. 2008 Aug;32(8):644-8
pubmed: 18782137
Exerc Sport Sci Rev. 2005 Jan;33(1):49-53
pubmed: 15640721
Front Neurosci. 2020 May 25;14:416
pubmed: 32528238
Syst Rev. 2015 Jan 01;4:1
pubmed: 25554246
Clin Neurophysiol. 2020 Jul;131(7):1519-1532
pubmed: 32403065
Neurosci Lett. 2015 Mar 4;589:144-9
pubmed: 25600855
Physiol Rep. 2020 Mar;8(5):e14397
pubmed: 32170844
PLoS One. 2019 Mar 7;14(3):e0213696
pubmed: 30845251
J Electromyogr Kinesiol. 2020 Aug;53:102438
pubmed: 32569878
J Neurotrauma. 2018 Sep 15;35(18):2145-2158
pubmed: 29649928
J Appl Physiol (1985). 2015 Jun 1;118(11):1364-74
pubmed: 25814642
Front Neurol. 2020 Jun 30;11:607
pubmed: 32714270
Muscle Nerve. 2007 Mar;35(3):327-36
pubmed: 17117411
Fiziol Cheloveka. 2016 May-Jun;42(3):32-6
pubmed: 29446609
Brain. 2014 May;137(Pt 5):1394-409
pubmed: 24713270
J Neurotrauma. 2018 Nov 1;35(21):2540-2553
pubmed: 29786465
Brain Stimul. 2020 Jan - Feb;13(1):20-34
pubmed: 31585723
Behav Res Methods. 2007 May;39(2):175-91
pubmed: 17695343
Bioelectromagnetics. 2013 Dec;34(8):630-40
pubmed: 24115026
Neuroscientist. 2017 Dec;23(6):649-663
pubmed: 28351197
Arch Phys Med Rehabil. 2012 Sep;93(9):1487-97
pubmed: 22920448
J Physiol. 2007 Aug 1;582(Pt 3):1125-39
pubmed: 17446226
Artif Organs. 2011 Mar;35(3):257-62
pubmed: 21401670
Ann Phys Rehabil Med. 2015 Sep;58(4):232-237
pubmed: 26100230
Spinal Cord. 2012 Oct;50(10):718-27
pubmed: 22777488
Neurorehabil Neural Repair. 2016 Mar;30(3):233-43
pubmed: 26089308
J Neurotrauma. 2019 May 1;36(9):1435-1450
pubmed: 30362876
Neurosci Lett. 2020 Jul 27;732:135052
pubmed: 32439478
IEEE Trans Neural Syst Rehabil Eng. 2020 Dec;28(12):3167-3174
pubmed: 33382659
Nat Med. 2018 Nov;24(11):1677-1682
pubmed: 30250140
Sci Rep. 2018 Oct 19;8(1):15546
pubmed: 30341390
Ann Clin Transl Neurol. 2020 May;7(5):829-838
pubmed: 32436278
J Neurosci. 2020 Mar 25;40(13):2633-2643
pubmed: 31996455
Front Hum Neurosci. 2021 Jun 03;15:660583
pubmed: 34149379
Front Hum Neurosci. 2021 Feb 18;15:620414
pubmed: 33679347
J Neurophysiol. 2014 Mar;111(5):1088-99
pubmed: 24335213
PLoS One. 2016 Jan 21;11(1):e0147479
pubmed: 26797502
J Neurosci Methods. 2009 May 30;180(1):111-5
pubmed: 19427537
Spinal Cord. 2011 Jan;49(1):87-93
pubmed: 20585326
IEEE Trans Neural Syst Rehabil Eng. 2010 Dec;18(6):637-45
pubmed: 21138794