Experimental deep brain stimulation in rodent models of movement disorders.
DBS technology
Deep brain stimulation
Dystonia
Parkinson's disease
Rodent models
Journal
Experimental neurology
ISSN: 1090-2430
Titre abrégé: Exp Neurol
Pays: United States
ID NLM: 0370712
Informations de publication
Date de publication:
02 2022
02 2022
Historique:
received:
30
04
2021
revised:
14
09
2021
accepted:
11
11
2021
pubmed:
19
11
2021
medline:
18
1
2022
entrez:
18
11
2021
Statut:
ppublish
Résumé
Deep brain stimulation (DBS) is the preferred treatment for therapy-resistant movement disorders such as dystonia and Parkinson's disease (PD), mostly in advanced disease stages. Although DBS is already in clinical use for ~30 years and has improved patients' quality of life dramatically, there is still limited understanding of the underlying mechanisms of action. Rodent models of PD and dystonia are essential tools to elucidate the mode of action of DBS on behavioral and multiscale neurobiological levels. Advances have been made in identifying DBS effects on the central motor network, neuroprotection and neuroinflammation in DBS studies of PD rodent models. The phenotypic dt
Identifiants
pubmed: 34793784
pii: S0014-4886(21)00334-4
doi: 10.1016/j.expneurol.2021.113926
pii:
doi:
Substances chimiques
Brain-Derived Neurotrophic Factor
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
113926Informations de copyright
Copyright © 2021 The Authors. Published by Elsevier Inc. All rights reserved.