Cardiac ryanodine receptor N-terminal region biosensors identify novel inhibitors via FRET-based high-throughput screening.

Animals Biosensing Techniques Calcium / metabolism Fluorescence Resonance Energy Transfer High-Throughput Screening Assays Mice Muscle, Skeletal / chemistry Ryanodine Receptor Calcium Release Channel / analysis
FRET N-terminal region fluorescence lifetime high-throughput screening myopathy ryanodine receptor

Journal

The Journal of biological chemistry
ISSN: 1083-351X
Titre abrégé: J Biol Chem
Pays: United States
ID NLM: 2985121R

Informations de publication

Date de publication:
01 2022
Historique:
received: 06 02 2021
revised: 08 11 2021
accepted: 11 11 2021
pubmed: 19 11 2021
medline: 29 4 2022
entrez: 18 11 2021
Statut: ppublish

Résumé

The N-terminal region (NTR) of ryanodine receptor (RyR) channels is critical for the regulation of Ca

Identifiants

DOI: 10.1016/j.jbc.2021.101412 PMID: 34793835 PMC: PMC8689225
pubmed: 34793835
pii: S0021-9258(21)01219-9
doi: 10.1016/j.jbc.2021.101412
pmc: PMC8689225
pii:
doi:

Substances chimiques

Ryanodine Receptor Calcium Release Channel 0
Calcium SY7Q814VUP

Types de publication

Journal Article Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

101412

Subventions

Organisme : NHLBI NIH HHS
ID : R01 HL138539
Pays : United States
Organisme : NIA NIH HHS
ID : R43 AG069582
Pays : United States
Organisme : NIA NIH HHS
ID : R37 AG026160
Pays : United States
Organisme : NHLBI NIH HHS
ID : R01 HL092097
Pays : United States
Organisme : NHLBI NIH HHS
ID : R01 HL151990
Pays : United States
Organisme : NHLBI NIH HHS
ID : R01 HL151223
Pays : United States
Organisme : CIHR
ID : 125893
Pays : Canada

Informations de copyright

Copyright © 2021 The Authors. Published by Elsevier Inc. All rights reserved.

Déclaration de conflit d'intérêts

Conflict of interest D. D. T. and R. L. C. hold equity in and serve as executive officers for Photonic Pharma LLC. These relationships have been reviewed and managed by the University of Minnesota. Photonic Pharma had no role in this study.

Auteurs

Jingyan Zhang (J)

Department of Biochemistry, Molecular Biology and Biophysics, University of Minnesota, Minneapolis, Minnesota, USA.

Daniel P Singh (DP)

School of Biomedical Sciences, The University of Queensland, Brisbane, Queensland, Australia.

Christopher Y Ko (CY)

Department of Pharmacology, University of California, Davis, California, USA.

Roman Nikolaienko (R)

Department of Cell and Molecular Physiology, Loyola University Chicago, Chicago, Illinois, USA.

Siobhan M Wong King Yuen (SM)

Department of Biochemistry and Molecular Biology, Life Sciences Institute, University of British Columbia, Vancouver, British Columbia, Canada.

Jacob A Schwarz (JA)

Department of Biochemistry, Molecular Biology and Biophysics, University of Minnesota, Minneapolis, Minnesota, USA.

Levy M Treinen (LM)

Department of Biochemistry, Molecular Biology and Biophysics, University of Minnesota, Minneapolis, Minnesota, USA.

Ching-Chieh Tung (CC)

Department of Biochemistry and Molecular Biology, Life Sciences Institute, University of British Columbia, Vancouver, British Columbia, Canada.

Kaja Rožman (K)

Department of Medicinal Chemistry, University of Minnesota, Minneapolis, Minnesota, USA.

Bengt Svensson (B)

Department of Biochemistry, Molecular Biology and Biophysics, University of Minnesota, Minneapolis, Minnesota, USA.

Courtney C Aldrich (CC)

Department of Medicinal Chemistry, University of Minnesota, Minneapolis, Minnesota, USA.

Aleksey V Zima (AV)

Department of Cell and Molecular Physiology, Loyola University Chicago, Chicago, Illinois, USA.

David D Thomas (DD)

Department of Biochemistry, Molecular Biology and Biophysics, University of Minnesota, Minneapolis, Minnesota, USA.

Donald M Bers (DM)

Department of Pharmacology, University of California, Davis, California, USA.

Bradley S Launikonis (BS)

School of Biomedical Sciences, The University of Queensland, Brisbane, Queensland, Australia.

Filip Van Petegem (F)

Department of Biochemistry and Molecular Biology, Life Sciences Institute, University of British Columbia, Vancouver, British Columbia, Canada.

Razvan L Cornea (RL)

Department of Biochemistry, Molecular Biology and Biophysics, University of Minnesota, Minneapolis, Minnesota, USA. Electronic address: corne002@umn.edu.

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Cardiac ryanodine receptor N-terminal region...
questionsmedicales.fr › Techniques d'investigation › Techniques de sonde moléculaire › Techniques de biocapteur › Cardiac ryanodine receptor N-terminal region...
questionsmedicales.fr › Facteurs biologiques › Facteurs de la coagulation sanguine › Calcium › Cardiac ryanodine receptor N-terminal region...
questionsmedicales.fr › Phénomènes chimiques › Phénomènes biochimiques › Transfert d'énergie par résonance de fluorescence › Cardiac ryanodine receptor N-terminal region...
questionsmedicales.fr › Techniques d'investigation › Tests de criblage à haut débit › Cardiac ryanodine receptor N-terminal region...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Cardiac ryanodine receptor N-terminal region...
questionsmedicales.fr › Tissus › Muscles › Muscle strié › Muscles squelettiques › Cardiac ryanodine receptor N-terminal region...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines membranaires › Protéines de transport membranaire › Canaux ioniques › Canaux calciques › Canal de libération du calcium du récepteur à la ryanodine › Cardiac ryanodine receptor N-terminal region...