Autoimmunity May Explain Diabetes in a Subset of Patients With Recurrent Acute and Chronic Pancreatitis: A Pilot Study.
Journal
Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association
ISSN: 1542-7714
Titre abrégé: Clin Gastroenterol Hepatol
Pays: United States
ID NLM: 101160775
Informations de publication
Date de publication:
01 2023
01 2023
Historique:
received:
03
11
2021
accepted:
10
11
2021
pubmed:
19
11
2021
medline:
27
12
2022
entrez:
18
11
2021
Statut:
ppublish
Résumé
Pancreatogenic diabetes mellitus, also termed type 3c diabetes (T3cD), or glucose intolerance develops in 25%-75% of adults with chronic pancreatitis (CP). The primary pathophysiologic defect in T3cD is insulin deficiency, thought to result largely from "bystander" injury to the islets from fibrotic changes in the exocrine pancreas and cytokine-induced beta cell dysfunction from intrapancreatic inflammation.
Identifiants
pubmed: 34793964
pii: S1542-3565(21)01223-4
doi: 10.1016/j.cgh.2021.11.011
pii:
doi:
Substances chimiques
Insulin
0
Banques de données
ClinicalTrials.gov
['NCT01545167']
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Langues
eng
Sous-ensembles de citation
IM
Pagination
226-228.e1Investigateurs
Samer AlKaade
(S)
Stephen T Amann
(ST)
Michelle A Anderson
(MA)
Peter Banks
(P)
Darwin Conwell
(D)
Randall E Brand
(RE)
Gregory A Cote
(GA)
Joseph Romagnuolo
(J)
Christopher E Forsmark
(CE)
Timothy Gardner
(T)
Andres Gelrud
(A)
Nalini Guda
(N)
Michele Lewis
(M)
Thiruvengadam Muniraj
(T)
Bimaljit S Sandhu
(BS)
Stuart Sherman
(S)
Vikesh Singh
(V)
C Mel Wilcox
(CM)
Informations de copyright
Copyright © 2023. Published by Elsevier Inc.