Immunophenotyping of intraepithelial lymphocytes in canine chronic enteropathy and intestinal T-cell lymphoma using endoscopic samples.
PCR for antigen receptor rearrangement
dogs
endoscopy
enteropathy-associated T-cell lymphoma
immunohistochemistry
inflammatory bowel disease
intestinal lymphoma
Journal
Veterinary pathology
ISSN: 1544-2217
Titre abrégé: Vet Pathol
Pays: United States
ID NLM: 0312020
Informations de publication
Date de publication:
03 2022
03 2022
Historique:
pubmed:
20
11
2021
medline:
19
4
2022
entrez:
19
11
2021
Statut:
ppublish
Résumé
Human enteropathy-associated T-cell lymphoma (EATL) is considered to be derived from intraepithelial lymphocytes (IELs); however, the origin of canine intestinal T-cell lymphoma (ITCL) remains unclear. Histological, immunohistochemical, and clonality examinations were performed using endoscopically collected canine duodenum samples of mucosal lesions of chronic enteropathy (CE; 73 cases) and ITCL without transmural neoplastic mass lesions (64 cases). Histopathological examinations revealed the intraepithelial accumulation of lymphocytes (called "intraepithelial lymphocytosis") in 54/73 CE cases (74%) and the epitheliotropism of neoplastic lymphocytes in 63/64 ITCL cases (98%). Immunohistochemically, IELs in CE with intraepithelial lymphocytosis (IEL
Identifiants
pubmed: 34794367
doi: 10.1177/03009858211057220
doi:
Substances chimiques
Antigens, CD20
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM