Challenges and Experiences Extending the cBioPortal for Cancer Genomics to a Molecular Tumor Board Platform.

Genomics Humans Neoplasms / genetics
Docker Genomics MIRACUM Molecular Tumor Board Precision Medicine cBioPortal

Journal

Studies in health technology and informatics
ISSN: 1879-8365
Titre abrégé: Stud Health Technol Inform
Pays: Netherlands
ID NLM: 9214582

Informations de publication

Date de publication:
18 Nov 2021
Historique:
entrez: 19 11 2021
pubmed: 20 11 2021
medline: 23 11 2021
Statut: ppublish

Résumé

In Molecular Tumor Boards (MTBs), therapy recommendations for cancer patients are discussed. To aid decision-making based on the patient's molecular profile, the research platform cBioPortal was extended based on users' requirements. Additionally, a comprehensive dockerized workflow was developed to support the deployment of cBioPortal and connected services. In this work, we present the challenges and experiences of nearly two years of implementing and deploying an MTB platform based on cBioPortal and compare those to findings of a previous study.

Identifiants

DOI: 10.3233/SHTI210833 PMID: 34795098
pubmed: 34795098
pii: SHTI210833
doi: 10.3233/SHTI210833
doi:

Types de publication

Journal Article

Langues

eng

Pagination

139-143

Auteurs

Niklas Reimer (N)

Group for Medical Systems Biology, Lübeck Institute of Experimental Dermatology, Universität zu Lübeck, Germany.

Philipp Unberath (P)

Group for Medical Systems Biology, Lübeck Institute of Experimental Dermatology, Universität zu Lübeck, Germany.

Hauke Busch (H)

Group for Medical Systems Biology, Lübeck Institute of Experimental Dermatology, Universität zu Lübeck, Germany.

Melanie Börries (M)

Institute of Medical Bioinformatics and Systems Medicine, Faculty of Medicine and Medical Center - University of Freiburg, Freiburg, Germany.
German Cancer Consortium (DKTK) Partner Site Freiburg and Cancer Research Center (DKFZ), Heidelberg, Germany.

Patrick Metzger (P)

Institute of Medical Bioinformatics and Systems Medicine, Faculty of Medicine and Medical Center - University of Freiburg, Freiburg, Germany.

Arsenij Ustjanzew (A)

Institute of Medical Biostatistics, Epidemiology and Informatics (IMBEI), Johannes Gutenberg-University School of Medicine, Mainz, Germany.

Christopher Renner (C)

Department of Medical Informatics, Friedrich-Alexander-Universität Erlangen-Nürnberg, Erlangen, Germany.

Hans-Ulrich Prokosch (HU)

Department of Medical Informatics, Friedrich-Alexander-Universität Erlangen-Nürnberg, Erlangen, Germany.

Jan Christoph (J)

Department of Medical Informatics, Friedrich-Alexander-Universität Erlangen-Nürnberg, Erlangen, Germany.
Junior Research Group (Bio-)Medical Data Science, Martin-Luther-University Halle-Wittenberg, Faculty of Medicine, Halle, Germany.

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Classifications MeSH

questionsmedicales.fr › Disciplines des sciences naturelles › Disciplines des sciences biologiques › Biologie › Génétique › Génomique › Challenges and Experiences Extending the...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Challenges and Experiences Extending the...
questionsmedicales.fr › Tumeurs › Challenges and Experiences Extending the...