Association between Parkinson's disease and the faecal eukaryotic microbiota.


Journal

NPJ Parkinson's disease
ISSN: 2373-8057
Titre abrégé: NPJ Parkinsons Dis
Pays: United States
ID NLM: 101675390

Informations de publication

Date de publication:
18 Nov 2021
Historique:
received: 03 02 2021
accepted: 21 10 2021
entrez: 19 11 2021
pubmed: 20 11 2021
medline: 20 11 2021
Statut: epublish

Résumé

Parkinson's disease (PD) is one of the most common neurodegenerative disease, and is so far not considered curable. PD patients suffer from several motor and non-motor symptoms, including gastrointestinal dysfunctions and alterations of the enteric nervous system. Constipation and additional intestinal affections can precede the classical motor symptoms by several years. Recently, we reported effects of PD and related medications on the faecal bacterial community of 34 German PD patients and 25 age-matched controls. Here, we used the same collective and analysed the V6 and V7 hypervariable region of PCR-amplified, eukaryotic 18S rRNA genes using an Illumina MiSeq platform. In all, 53% (18) of the PD samples and 72% (18) of the control samples yielded sufficient amplicons for downstream community analyses. The PD samples showed a significantly lower alpha and a different beta eukaryotic diversity than the controls. Most strikingly, we observed a significantly higher relative abundance of sequence affiliated with the Geotrichum genus in the PD samples (39.7%), when compared to the control samples (0.05%). In addition, we observed lower relative abundances of sequences affiliated with Aspergillus/Penicillium, Charophyta/Linum, unidentified Opisthokonta and three genera of minor abundant zooflagellates in the PD samples. Our data add knowledge to the small body of data about the eukaryotic microbiota of PD patients and suggest a potential association of certain gut eukaryotes and PD.

Identifiants

pubmed: 34795317
doi: 10.1038/s41531-021-00244-0
pii: 10.1038/s41531-021-00244-0
pmc: PMC8602383
doi:

Types de publication

Journal Article

Langues

eng

Pagination

101

Subventions

Organisme : Bundesministerium für Bildung und Forschung (Federal Ministry of Education and Research)
ID : 03FH036PB5
Organisme : Bundesministerium für Bildung und Forschung (Federal Ministry of Education and Research)
ID : 03FH036PB5

Informations de copyright

© 2021. The Author(s).

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Auteurs

Severin Weis (S)

Faculty of Medical and Life Sciences, Institute of Precision Medicine, Microbiology and Hygiene Group, Furtwangen University, Villingen-Schwenningen, Germany.

Alexandra Meisner (A)

Faculty of Medical and Life Sciences, Institute of Precision Medicine, Microbiology and Hygiene Group, Furtwangen University, Villingen-Schwenningen, Germany.

Andreas Schwiertz (A)

MVZ Institute of Microecology, Herborn, Germany.

Marcus M Unger (MM)

Department of Neurology, Saarland University, Homburg, Germany.

Anouck Becker (A)

Department of Neurology, Saarland University, Homburg, Germany.

Klaus Faßbender (K)

Department of Neurology, Saarland University, Homburg, Germany.

Sylvia Schnell (S)

Institute of Applied Microbiology, Justus-Liebig-University, Giessen, Germany.

Karl-Herbert Schäfer (KH)

Working Group Enteric Nervous System (AGENS), University of Applied Sciences Kaiserslautern, Zweibrücken, Germany.

Markus Egert (M)

Faculty of Medical and Life Sciences, Institute of Precision Medicine, Microbiology and Hygiene Group, Furtwangen University, Villingen-Schwenningen, Germany. Markus.Egert@hs-furtwangen.de.

Classifications MeSH