Comparison of liver scintigraphy and the liver-spleen contrast in Gd-EOB-DTPA-enhanced MRI on liver function tests.
Aged
Aged, 80 and over
Albumins
/ analysis
Bilirubin
/ analysis
Contrast Media
Female
Gadolinium DTPA
/ chemistry
Humans
Image Processing, Computer-Assisted
/ methods
Liver
/ diagnostic imaging
Liver Function Tests
Magnetic Resonance Imaging
/ methods
Male
Middle Aged
Radionuclide Imaging
/ methods
Reproducibility of Results
Spleen
/ diagnostic imaging
Tomography, X-Ray Computed
Journal
Scientific reports
ISSN: 2045-2322
Titre abrégé: Sci Rep
Pays: England
ID NLM: 101563288
Informations de publication
Date de publication:
18 11 2021
18 11 2021
Historique:
received:
06
09
2021
accepted:
02
11
2021
entrez:
19
11
2021
pubmed:
20
11
2021
medline:
24
2
2022
Statut:
epublish
Résumé
The liver-spleen contrast (LSC) using hepatobiliary-phase images could replace the receptor index (LHL15) in liver scintigraphy; however, few comparative studies exist. This study aimed to verify the convertibility from LSC into LHL15. In 136 patients, the LSC, not at 20 min, but at 60 min after injecting gadolinium-ethoxybenzyl-diethylenetriaminepentaacetic acid was compared with the LHL15, albumin-bilirubin (ALBI) score, and the related laboratory parameters. The LHL15 was also compared with their biochemical tests. The correlation coefficients of LSC with LHL15, ALBI score, total bilirubin, and albumin were 0.740, -0.624, -0.606, and 0.523 (P < 0.00001), respectively. The correlation coefficients of LHL15 with ALBI score, total bilirubin, and albumin were -0.647, -0.553, and 0.569 (P < 0.00001), respectively. The linear regression equation on the estimated LHL15 (eLHL15) from LSC was eLHL15 = 0.460 · LSC + 0.727 (P < 0.00001) and the coefficient of determination was 0.548. Regarding a contingency table using imaging-based clinical stage classification, the degree of agreement between eLHL15 and LHL15 was 65.4%, and Cramer's V was 0.568 (P < 0.00001). Therefore, although the LSC may be influenced by high total bilirubin, the eLHL15 can replace the LSC as an index to evaluate liver function.
Identifiants
pubmed: 34795343
doi: 10.1038/s41598-021-01815-0
pii: 10.1038/s41598-021-01815-0
pmc: PMC8602720
doi:
Substances chimiques
Albumins
0
Contrast Media
0
gadolinium ethoxybenzyl DTPA
0
Gadolinium DTPA
K2I13DR72L
Bilirubin
RFM9X3LJ49
Types de publication
Comparative Study
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
22472Informations de copyright
© 2021. The Author(s).
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