Induction of Anti-Aquaporin 5 Autoantibody Production by Immunization with a Peptide Derived from the Aquaporin of
Aquaporin-5
Autoantibodies
Mice
Molecular mimicry
Sjogren's syndrome
Journal
Immune network
ISSN: 1598-2629
Titre abrégé: Immune Netw
Pays: Korea (South)
ID NLM: 101137270
Informations de publication
Date de publication:
Oct 2021
Oct 2021
Historique:
received:
18
06
2021
revised:
19
09
2021
accepted:
14
10
2021
entrez:
19
11
2021
pubmed:
20
11
2021
medline:
20
11
2021
Statut:
epublish
Résumé
Sjögren's syndrome (SS) is an autoimmune disease characterized by dryness of the mouth and eyes. The glandular dysfunction in SS involves not only T cell-mediated destruction of the glands but also autoantibodies against the type 3 muscarinic acetylcholine receptor or aquaporin 5 (AQP5) that interfere with the secretion process. Studies on the breakage of tolerance and induction of autoantibodies to these autoantigens could benefit SS patients. To break tolerance, we utilized a PmE-L peptide derived from the AQP5-homologous aquaporin of
Identifiants
pubmed: 34796038
doi: 10.4110/in.2021.21.e34
pmc: PMC8568913
doi:
Types de publication
Journal Article
Langues
eng
Pagination
e34Informations de copyright
Copyright © 2021. The Korean Association of Immunologists.
Déclaration de conflit d'intérêts
Conflict of Interest: The authors declare no potential conflicts of interest.
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