R-loops trigger the release of cytoplasmic ssDNAs leading to chronic inflammation upon DNA damage.
Journal
Science advances
ISSN: 2375-2548
Titre abrégé: Sci Adv
Pays: United States
ID NLM: 101653440
Informations de publication
Date de publication:
19 11 2021
19 11 2021
Historique:
entrez:
19
11
2021
pubmed:
20
11
2021
medline:
19
4
2022
Statut:
ppublish
Résumé
How DNA damage leads to chronic inflammation and tissue degeneration with aging remains to be fully resolved. Here, we show that DNA damage leads to cellular senescence, fibrosis, loss-of-tissue architecture, and chronic pancreatitis in mice with an inborn defect in the excision repair cross complementation group 1 (
Identifiants
pubmed: 34797720
doi: 10.1126/sciadv.abj5769
pmc: PMC8604417
doi:
Substances chimiques
DNA, Single-Stranded
0
DNA-Binding Proteins
0
Endonucleases
EC 3.1.-
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
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