Visualizing in deceased COVID-19 patients how SARS-CoV-2 attacks the respiratory and olfactory mucosae but spares the olfactory bulb.
Aged
Anosmia
Autopsy
/ methods
COVID-19
/ mortality
Endoscopy
/ methods
Female
Glucuronosyltransferase
/ biosynthesis
Humans
Immunohistochemistry
In Situ Hybridization
Male
Microscopy, Fluorescence
Middle Aged
Olfaction Disorders
Olfactory Bulb
/ virology
Olfactory Mucosa
/ virology
Olfactory Receptor Neurons
/ metabolism
Respiratory Mucosa
/ virology
Respiratory System
SARS-CoV-2
Smell
B.1.1.7
COVID-19
SARS-CoV-2
UGT2A1
coronavirus
leptomeninges
olfactory bulb
olfactory receptor
olfactory sensory neuron
sustentacular cell
Journal
Cell
ISSN: 1097-4172
Titre abrégé: Cell
Pays: United States
ID NLM: 0413066
Informations de publication
Date de publication:
24 11 2021
24 11 2021
Historique:
received:
29
06
2021
revised:
01
09
2021
accepted:
25
10
2021
pubmed:
20
11
2021
medline:
15
12
2021
entrez:
19
11
2021
Statut:
ppublish
Résumé
Anosmia, the loss of smell, is a common and often the sole symptom of COVID-19. The onset of the sequence of pathobiological events leading to olfactory dysfunction remains obscure. Here, we have developed a postmortem bedside surgical procedure to harvest endoscopically samples of respiratory and olfactory mucosae and whole olfactory bulbs. Our cohort of 85 cases included COVID-19 patients who died a few days after infection with SARS-CoV-2, enabling us to catch the virus while it was still replicating. We found that sustentacular cells are the major target cell type in the olfactory mucosa. We failed to find evidence for infection of olfactory sensory neurons, and the parenchyma of the olfactory bulb is spared as well. Thus, SARS-CoV-2 does not appear to be a neurotropic virus. We postulate that transient insufficient support from sustentacular cells triggers transient olfactory dysfunction in COVID-19. Olfactory sensory neurons would become affected without getting infected.
Identifiants
pubmed: 34798069
pii: S0092-8674(21)01282-4
doi: 10.1016/j.cell.2021.10.027
pmc: PMC8564600
pii:
doi:
Substances chimiques
Glucuronosyltransferase
EC 2.4.1.17
UGT2A1 protein, human
EC 2.4.1.17
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
5932-5949.e15Informations de copyright
Copyright © 2021 The Author(s). Published by Elsevier Inc. All rights reserved.
Déclaration de conflit d'intérêts
Declaration of interests T.D.H., A.N., L.P., and J.W.R. are employees and stockholders at NanoString Technologies, Inc.
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