Structure-activity relationship and molecular modelling studies of quinazolinedione derivatives MMV665916 as potential antimalarial agent.

Antimalarials / chemical synthesis Dose-Response Relationship, Drug Enzyme Inhibitors / chemical synthesis Farnesyltranstransferase / antagonists & inhibitors Models, Molecular Molecular Structure Parasitic Sensitivity Tests Plasmodium falciparum / drug effects Structure-Activity Relationship
Antiplasmodial activity Farnesyltransferase Molecular docking Quinazolinedione series

Journal

Bioorganic & medicinal chemistry
ISSN: 1464-3391
Titre abrégé: Bioorg Med Chem
Pays: England
ID NLM: 9413298

Informations de publication

Date de publication:
01 12 2021
Historique:
received: 23 06 2021
revised: 11 10 2021
accepted: 17 10 2021
pubmed: 20 11 2021
medline: 19 1 2022
entrez: 19 11 2021
Statut: ppublish

Résumé

A series of new quinazolinedione derivatives have been readily synthesized and evaluated for their in vitro antiplasmodial growth inhibition activity. Most of the compounds inhibited P. falciparum FcB1 strain in the low to medium micromolar concentration. The 2-ethoxy 8ag', 2-trifluoromethoxy 8ai' and 4-fluoro-2-methoxy 8ak' showed the best inhibitory activity with EC

Identifiants

DOI: 10.1016/j.bmc.2021.116513 PMID: 34798379
pubmed: 34798379
pii: S0968-0896(21)00521-6
doi: 10.1016/j.bmc.2021.116513
pii:
doi:

Substances chimiques

Antimalarials 0
Enzyme Inhibitors 0
Farnesyltranstransferase EC 2.5.1.29

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

116513

Informations de copyright

Copyright © 2021 Elsevier Ltd. All rights reserved.

Auteurs

Laura Mourot (L)

Université de Haute-Alsace, Université de Strasbourg, CNRS, LIMA UMR 7042, F-68000 Mulhouse, France.

Marjorie Schmitt (M)

Université de Haute-Alsace, Université de Strasbourg, CNRS, LIMA UMR 7042, F-68000 Mulhouse, France.

Elisabeth Mouray (E)

Unité Molécules de Communication et Adaptation des Micro-organismes, UMR7245, Muséum National d'Histoire Naturelle, CNRS, Sorbonne Universités, Paris, France.

Martin Spichty (M)

Université de Haute-Alsace, Université de Strasbourg, CNRS, LIMA UMR 7042, F-68000 Mulhouse, France.

Isabelle Florent (I)

Unité Molécules de Communication et Adaptation des Micro-organismes, UMR7245, Muséum National d'Histoire Naturelle, CNRS, Sorbonne Universités, Paris, France.

Sébastien Albrecht (S)

Université de Haute-Alsace, Université de Strasbourg, CNRS, LIMA UMR 7042, F-68000 Mulhouse, France. Electronic address: sebastien.albrecht@uha.fr.

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Classifications MeSH

questionsmedicales.fr › Actions chimiques et utilisations › Actions pharmacologiques › Utilisations thérapeutiques › Anti-infectieux › Antiparasitaires › Antiprotozoaires › Antipaludiques › Structure-activity relationship and molecular...
questionsmedicales.fr › Phénomènes physiologiques › Phénomènes pharmacologiques et toxicologiques › Phénomènes toxicologiques › Relation dose-effet des médicaments › Structure-activity relationship and molecular...
questionsmedicales.fr › Actions chimiques et utilisations › Actions pharmacologiques › Mécanismes moléculaires de l'action pharmacologique › Antienzymes › Structure-activity relationship and molecular...
questionsmedicales.fr › Enzymes et coenzymes › Enzymes › Transferases › Alkyl et aryl transferases › Farnesyltranstransferase › Structure-activity relationship and molecular...
questionsmedicales.fr › Techniques d'investigation › Modèles théoriques › Modèles moléculaires › Structure-activity relationship and molecular...
questionsmedicales.fr › Phénomènes chimiques › Structure moléculaire › Structure-activity relationship and molecular...
questionsmedicales.fr › Techniques d'investigation › Évaluation préclinique de médicament › Tests de sensibilité parasitaire › Structure-activity relationship and molecular...
questionsmedicales.fr › Eucaryotes › Alveolata › Apicomplexa › Haemosporida › Plasmodium › Plasmodium falciparum › Structure-activity relationship and molecular...
questionsmedicales.fr › Phénomènes physiologiques › Phénomènes pharmacologiques et toxicologiques › Phénomènes pharmacologiques › Relation structure-activité › Structure-activity relationship and molecular...