The E3 ubiquitin ligase adaptor
Drosophila
circadian rhythms
neuronal output
potassium current
ubiquitin ligase
Journal
Proceedings of the National Academy of Sciences of the United States of America
ISSN: 1091-6490
Titre abrégé: Proc Natl Acad Sci U S A
Pays: United States
ID NLM: 7505876
Informations de publication
Date de publication:
23 11 2021
23 11 2021
Historique:
accepted:
04
10
2021
entrez:
20
11
2021
pubmed:
21
11
2021
medline:
22
12
2021
Statut:
ppublish
Résumé
Circadian transcriptional timekeepers in pacemaker neurons drive profound daily rhythms in sleep and wake. Here we reveal a molecular pathway that links core transcriptional oscillators to neuronal and behavioral rhythms. Using two independent genetic screens, we identified mutants of
Identifiants
pubmed: 34799448
pii: 2110767118
doi: 10.1073/pnas.2110767118
pmc: PMC8617488
pii:
doi:
Substances chimiques
Cul3 protein, Drosophila
0
Cullin Proteins
0
Drosophila Proteins
0
Neuropeptides
0
pdf protein, Drosophila
0
tgo protein, Drosophila
0
Aryl Hydrocarbon Receptor Nuclear Translocator
138391-32-9
Ubiquitin-Protein Ligases
EC 2.3.2.27
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, Non-P.H.S.
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : NINDS NIH HHS
ID : R01 NS106955
Pays : United States
Organisme : NINDS NIH HHS
ID : R56 NS052903
Pays : United States
Organisme : NHLBI NIH HHS
ID : T32 HL007909
Pays : United States
Informations de copyright
Copyright © 2021 the Author(s). Published by PNAS.
Déclaration de conflit d'intérêts
The authors declare no competing interest.
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