The small molecule Zaractin activates ZAR1-mediated immunity in
Arabidopsis
/ drug effects
Arabidopsis Proteins
/ metabolism
Bacterial Proteins
/ metabolism
Carrier Proteins
/ metabolism
NLR Proteins
/ metabolism
Plant Diseases
/ microbiology
Plant Immunity
/ drug effects
Protein Binding
/ drug effects
Pseudomonas syringae
/ pathogenicity
Small Molecule Libraries
/ pharmacology
Arabidopsis
Pseudomonas syringae
chemical biology: zaractin
immunity
type III effector
Journal
Proceedings of the National Academy of Sciences of the United States of America
ISSN: 1091-6490
Titre abrégé: Proc Natl Acad Sci U S A
Pays: United States
ID NLM: 7505876
Informations de publication
Date de publication:
23 11 2021
23 11 2021
Historique:
accepted:
08
10
2021
entrez:
20
11
2021
pubmed:
21
11
2021
medline:
15
12
2021
Statut:
ppublish
Résumé
Pathogenic effector proteins use a variety of enzymatic activities to manipulate host cellular proteins and favor the infection process. However, these perturbations can be sensed by nucleotide-binding leucine-rich-repeat (NLR) proteins to activate effector-triggered immunity (ETI). Here we have identified a small molecule (Zaractin) that mimics the immune eliciting activity of the
Identifiants
pubmed: 34799454
pii: 2116570118
doi: 10.1073/pnas.2116570118
pmc: PMC8617420
pii:
doi:
Substances chimiques
Arabidopsis Proteins
0
Bacterial Proteins
0
Carrier Proteins
0
NLR Proteins
0
Small Molecule Libraries
0
ZAR1 protein, Arabidopsis
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Déclaration de conflit d'intérêts
The authors declare no competing interest.
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