Clinical Trial Participation: A Pilot Study of Patient-Identified Barriers.
clinical trial
enrollment
mixed-methods survey
patient-related barriers
Journal
Clinical journal of oncology nursing
ISSN: 1538-067X
Titre abrégé: Clin J Oncol Nurs
Pays: United States
ID NLM: 9705336
Informations de publication
Date de publication:
01 12 2021
01 12 2021
Historique:
entrez:
20
11
2021
pubmed:
21
11
2021
medline:
5
4
2022
Statut:
ppublish
Résumé
Clinical trial enrollment in the United States is lacking, particularly among older adult and ethnic and racial minority populations. The aim of the current study was to identify patient-related barriers to clinical trial participation using a mixed-methods patient survey and to offer insights to develop evidence-based implementation strategies to address these barriers. A retrospective survey was conducted of patients who were not interested in participating in a clinical trial to quantify the reasons these patients chose not to participate. Directed qualitative content analysis was used to identify themes that emerged from the write-in responses. The greatest patient-reported barriers were misperceptions about placebos, a desire to not feel like a human guinea pig, uncertainty surrounding clinical trial treatment effectiveness compared to standard care, and concerns about additional appointments or tests. Oncology nurses can address patient enrollment barriers by providing targeted education and participating in the informed consent process.
Sections du résumé
BACKGROUND
Clinical trial enrollment in the United States is lacking, particularly among older adult and ethnic and racial minority populations.
OBJECTIVES
The aim of the current study was to identify patient-related barriers to clinical trial participation using a mixed-methods patient survey and to offer insights to develop evidence-based implementation strategies to address these barriers.
METHODS
A retrospective survey was conducted of patients who were not interested in participating in a clinical trial to quantify the reasons these patients chose not to participate. Directed qualitative content analysis was used to identify themes that emerged from the write-in responses.
FINDINGS
The greatest patient-reported barriers were misperceptions about placebos, a desire to not feel like a human guinea pig, uncertainty surrounding clinical trial treatment effectiveness compared to standard care, and concerns about additional appointments or tests. Oncology nurses can address patient enrollment barriers by providing targeted education and participating in the informed consent process.
Identifiants
pubmed: 34800100
doi: 10.1188/21.CJON.647-654
pmc: PMC10150445
mid: NIHMS1890526
doi:
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Pagination
647-654Subventions
Organisme : NCI NIH HHS
ID : P30 CA016056
Pays : United States
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