Assessment of the microvasculature in poppers maculopathy.
Drug toxicity
Multimodal imaging
OCT angiography
Poppers maculopathy
Retinal toxicity
Journal
Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie
ISSN: 1435-702X
Titre abrégé: Graefes Arch Clin Exp Ophthalmol
Pays: Germany
ID NLM: 8205248
Informations de publication
Date de publication:
Apr 2022
Apr 2022
Historique:
received:
03
04
2021
accepted:
12
10
2021
revised:
09
09
2021
pubmed:
21
11
2021
medline:
15
3
2022
entrez:
20
11
2021
Statut:
ppublish
Résumé
To investigate a possible microvascular component of poppers maculopathy (PMP) using optical coherence tomography angiography (OCTA). Twelve patients suffering from poppers maculopathy were included. Health records, optical coherence tomography (OCT), and OCTA data was gathered and compared to a healthy control group (HC). PMP lesion type was determined by manifestation in OCT. OCTA-based evaluation of retinal vascular plexus and choriocapillaris (CC) was executed. Vessel density (VD) and vessel length density (VLD) in superficial and deep capillary plexus (SCP, DCP), as well as flow deficits (FD), within the foveal avascular zone (FAZ) in CC were assessed. Median age of PMP patients was 40 (min 24; max 64) years, all male. Eleven patients presented with ellipsoid zone-type lesions; one patient showed a vitelliform-type lesion. No qualitative microvascular changes between PMP patients and HC were identified. Quantitative values for VD and VLD of SCP and DCP did not differ in between the two groups. The analysis of FDs in CC showed no deviation from PMP patients to HC. No vascular anomalies in qualitative and quantitative analysis in OCTA were detected in PMP patients. The constitution of the CC within FAZ of PMP patients does not differ from HC when assessed as FD.
Identifiants
pubmed: 34800139
doi: 10.1007/s00417-021-05453-0
pii: 10.1007/s00417-021-05453-0
pmc: PMC8913571
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
1299-1306Informations de copyright
© 2021. The Author(s).
Références
J Neurol Sci. 2009 Oct 15;285(1-2):259-61
pubmed: 19643446
Sci Rep. 2018 Jul 4;8(1):10143
pubmed: 29973663
Eye (Lond). 2012 Nov;26(11):1479-86
pubmed: 23079752
J Fr Ophtalmol. 2017 Feb;40(2):e49-e50
pubmed: 28126269
Ophthalmology. 2017 Sep;124(9):1425-1427
pubmed: 28648381
Ophthalmologica. 2018;239(2-3):74-84
pubmed: 29353272
Acta Ophthalmol. 2016 Feb;94(1):e82-3
pubmed: 25975842
Int J Retina Vitreous. 2016 Aug 15;2:19
pubmed: 27847637
Acta Diabetol. 2017 Jul;54(7):695-702
pubmed: 28474119
Retin Cases Brief Rep. 2020 Spring;14(2):195-199
pubmed: 29135704
Eye (Lond). 2012 Jun;26(6):888
pubmed: 22402700
Eur J Ophthalmol. 2021 Mar;31(2):NP71-NP73
pubmed: 31746225
GMS Ophthalmol Cases. 2020 Apr 02;10:Doc16
pubmed: 32676261
Invest Ophthalmol Vis Sci. 2007 Nov;48(11):5168-77
pubmed: 17962470
Br J Ophthalmol. 2017 Sep;101(9):1193-1200
pubmed: 28057649
BMJ Open Ophthalmol. 2017 Apr 03;1(1):e000015
pubmed: 29354696
Antioxidants (Basel). 2020 Apr 23;9(4):
pubmed: 32340220
Curr Eye Res. 2007 Mar;32(3):259-69
pubmed: 17453946
Arch Ophthalmol. 2011 Jun;129(6):703-8
pubmed: 21320953
Eye (Lond). 2013 Dec;27(12):1420-1
pubmed: 24113304
Semin Ophthalmol. 2004 Sep-Dec;19(3-4):105-6
pubmed: 15590547
Prog Retin Eye Res. 2018 May;64:1-55
pubmed: 29229445
Semin Ophthalmol. 2016;31(5):479-84
pubmed: 25398125
J Exp Biol. 2008 Jun;211(Pt 11):1792-804
pubmed: 18490395