Primary Central Nervous System Lymphomas.

Aged Antineoplastic Combined Chemotherapy Protocols Central Nervous System Central Nervous System Neoplasms / therapy Combined Modality Therapy Humans Lymphoma, Non-Hodgkin / drug therapy Methotrexate / therapeutic use Neoplasm Recurrence, Local Stem Cell Transplantation
Autologous stem cell transplant High-dose methotrexate Primary central nervous system lymphoma Thiotepa Whole-brain radiation therapy

Journal

Hematology/oncology clinics of North America
ISSN: 1558-1977
Titre abrégé: Hematol Oncol Clin North Am
Pays: United States
ID NLM: 8709473

Informations de publication

Date de publication:
02 2022
Historique:
entrez: 21 11 2021
pubmed: 22 11 2021
medline: 19 3 2022
Statut: ppublish

Résumé

Primary central nervous system lymphoma is a rare and aggressive extranodal non-Hodgkin lymphoma restricted to the brain, spinal cord, cerebrospinal fluid, and eyes. Optimization of treatment including high-dose methotrexate-based chemotherapy followed by consolidation therapy in the form of autologous stem cell transplant or whole-brain radiation leads to improved survival. However, several patients do not respond to upfront therapy and the relapse risk is high. Additionally, there is a risk of delayed neurotoxicity, particularly in older patients. Recent molecular insights underlying the pathophysiology of PCNSL have led to the development of clinical trials involving targeted therapies and immunotherapies for salvage.

Identifiants

DOI: 10.1016/j.hoc.2021.09.004 PMID: 34801161
pubmed: 34801161
pii: S0889-8588(21)00119-2
doi: 10.1016/j.hoc.2021.09.004
pii:
doi:

Substances chimiques

Methotrexate YL5FZ2Y5U1

Types de publication

Journal Article Research Support, Non-U.S. Gov't Review

Langues

eng

Sous-ensembles de citation

IM

Pagination

147-159

Informations de copyright

Copyright © 2021 Elsevier Inc. All rights reserved.

Auteurs

Ugonma Chukwueke (U)

Dana-Farber Cancer Institute, Boston, MA, USA; Brigham and Women's Hospital; Harvard Medical School.

Christian Grommes (C)

Memorial Sloan-Kettering Cancer Center, New York, NY, USA.

Lakshmi Nayak (L)

Dana-Farber Cancer Institute, Boston, MA, USA; Brigham and Women's Hospital; Harvard Medical School. Electronic address: Lakshmi_Nayak@dfci.harvard.edu.

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Classifications MeSH

questionsmedicales.fr › Personnes › Tranches d'âge › Adulte › Sujet âgé › Primary Central Nervous System Lymphomas.
questionsmedicales.fr › Thérapeutique › Traitement médicamenteux › Association de médicaments › Protocoles de polychimiothérapie antinéoplasique › Primary Central Nervous System Lymphomas.
questionsmedicales.fr › Système nerveux › Système nerveux central › Primary Central Nervous System Lymphomas.
questionsmedicales.fr › Maladies du système nerveux › Tumeurs du système nerveux › Tumeurs du système nerveux central › Primary Central Nervous System Lymphomas.
questionsmedicales.fr › Thérapeutique › Association thérapeutique › Primary Central Nervous System Lymphomas.
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Primary Central Nervous System Lymphomas.
questionsmedicales.fr › Maladies du système immunitaire › Syndromes immunoprolifératifs › Syndromes lymphoprolifératifs › Lymphomes › Lymphome malin non hodgkinien › Primary Central Nervous System Lymphomas.
questionsmedicales.fr › Composés hétérocycliques › Composés hétérocycliques à cycles fusionnés › Composés hétérobicycliques › Ptéridines › Aminoptérine › Méthotrexate › Primary Central Nervous System Lymphomas.
questionsmedicales.fr › États, signes et symptômes pathologiques › Processus pathologiques › Processus néoplasiques › Récidive tumorale locale › Primary Central Nervous System Lymphomas.
questionsmedicales.fr › Procédures de chirurgie opératoire › Transplantation › Transplantation cellulaire › Transplantation de cellules souches › Primary Central Nervous System Lymphomas.