Cannabis exposure during adolescence: A uniquely sensitive period for neurobiological effects.

Adolescent Brain / drug effects Cannabis / toxicity Humans
Adolescence CB1 Cannabis Dopamine Endocannabinoids Psychosis Reward Schizophrenia THC

Journal

International review of neurobiology
ISSN: 2162-5514
Titre abrégé: Int Rev Neurobiol
Pays: United States
ID NLM: 0374740

Informations de publication

Date de publication:
2022
Historique:
entrez: 21 11 2021
pubmed: 22 11 2021
medline: 27 1 2022
Statut: ppublish

Résumé

Adolescence is a crucial developmental period where neural circuits are refined and the brain is especially vulnerable to external insults. The endocannabinoid (eCB) system undergoes changes during adolescence which affect the way in which it modulates the development of other systems, in particular dopamine circuits, which show protracted development into adolescence. Given the rise of cannabis use by adolescents and young people, as well as variants containing increasingly higher concentrations of THC, it is now crucial to understand the unique effects of adolescent exposure to cannabis on the developing brain and it might shape future adult vulnerabilities to conditions such as psychosis, schizophrenia, addiction and more. Here we discuss the development of the eCB system across the lifespan, how CB1 receptors modulate dopamine release and potential neurobiological and behavioral effects of adolescent THC exposure on the developing brain such as alterations in excitatory/inhibitory balance during this developmental period.

Identifiants

DOI: 10.1016/bs.irn.2021.07.002 PMID: 34801175
pubmed: 34801175
pii: S0074-7742(21)00049-0
doi: 10.1016/bs.irn.2021.07.002
pii:
doi:

Types de publication

Journal Article Review

Langues

eng

Sous-ensembles de citation

IM

Pagination

95-120

Informations de copyright

Copyright © 2022 Elsevier Inc. All rights reserved.

Auteurs

K Z Peters (KZ)

Department of Anatomy and Neurobiology, University of Maryland School of Medicine, Baltimore, MD, United States; Sussex Neuroscience, School of Psychology, University of Sussex, Falmer, United Kingdom. Electronic address: katezarapeters@gmail.com.

N E Zlebnik (NE)

Department of Anatomy and Neurobiology, University of Maryland School of Medicine, Baltimore, MD, United States.

J F Cheer (JF)

Department of Anatomy and Neurobiology, University of Maryland School of Medicine, Baltimore, MD, United States; Department of Psychiatry, University of Maryland School of Medicine, Baltimore, MD, United States; Program in Neuroscience, University of Maryland School of Medicine, Baltimore, MD, United States. Electronic address: jcheer@som.umaryland.edu.

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Classifications MeSH

questionsmedicales.fr › Personnes › Tranches d'âge › Adolescent › Cannabis exposure during adolescence: A...
questionsmedicales.fr › Système nerveux › Système nerveux central › Encéphale › Cannabis exposure during adolescence: A...
questionsmedicales.fr › Eucaryotes › Viridiplantae › Streptophyta › Embryophyta › Tracheobionta › Magnoliopsida › Rosanae › Rosales › Cannabaceae › Cannabis › Cannabis exposure during adolescence: A...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Cannabis exposure during adolescence: A...