Molecular pathways involved in COVID-19 and potential pathway-based therapeutic targets.
COVID-19
Drug targets
Molecular pathway
SARS-CoV-2
Journal
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie
ISSN: 1950-6007
Titre abrégé: Biomed Pharmacother
Pays: France
ID NLM: 8213295
Informations de publication
Date de publication:
Jan 2022
Jan 2022
Historique:
received:
26
09
2021
revised:
05
11
2021
accepted:
10
11
2021
pubmed:
22
11
2021
medline:
21
12
2021
entrez:
21
11
2021
Statut:
ppublish
Résumé
Deciphering the molecular downstream consequences of severe acute respiratory syndrome coronavirus (SARS-CoV)- 2 infection is important for a greater understanding of the disease and treatment planning. Furthermore, greater understanding of the underlying mechanisms of diagnostic and therapeutic strategies can help in the development of vaccines and drugs against COVID-19. At present, the molecular mechanisms of SARS-CoV-2 in the host cells are not sufficiently comprehended. Some of the mechanisms are proposed considering the existing similarities between SARS-CoV-2 and the other members of the β-CoVs, and others are explained based on studies advanced in the structure and function of SARS-CoV-2. In this review, we endeavored to map the possible mechanisms of the host response following SARS-CoV-2 infection and surveyed current research conducted by in vitro, in vivo and human observations, as well as existing suggestions. We addressed the specific signaling events that can cause cytokine storm and demonstrated three forms of cell death signaling following virus infection, including apoptosis, pyroptosis, and necroptosis. Given the elicited signaling pathways, we introduced possible pathway-based therapeutic targets; ADAM17 was especially highlighted as one of the most important elements of several signaling pathways involved in the immunopathogenesis of COVID-19. We also provided the possible drug candidates against these targets. Moreover, the cytokine-cytokine receptor interaction pathway was found as one of the important cross-talk pathways through a pathway-pathway interaction analysis for SARS-CoV-2 infection.
Identifiants
pubmed: 34801852
pii: S0753-3322(21)01206-3
doi: 10.1016/j.biopha.2021.112420
pmc: PMC8585639
pii:
doi:
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
112420Informations de copyright
Copyright © 2021. Published by Elsevier Masson SAS.
Références
Hypertension. 2011 Feb;57(2):245-54
pubmed: 21173344
J Exp Med. 1993 May 1;177(5):1277-86
pubmed: 8386742
J Allergy (Cairo). 2011;2011:742710
pubmed: 22220184
Nature. 2020 Mar;579(7798):270-273
pubmed: 32015507
Pharmacol Res. 2020 Jul;157:104854
pubmed: 32360585
Biochem Soc Trans. 2009 Feb;37(Pt 1):217-22
pubmed: 19143635
Immunogenetics. 2020 Jul;72(5):275-277
pubmed: 32342146
Front Immunol. 2015 Aug 18;6:422
pubmed: 26347745
Biomed Pharmacother. 2021 Nov;143:112176
pubmed: 34562770
Molecules. 2021 Feb 10;26(4):
pubmed: 33579029
Viruses. 2021 Feb 16;13(2):
pubmed: 33669276
Cell. 2008 Apr 18;133(2):235-49
pubmed: 18423196
Cell Rep. 2021 Apr 20;35(3):109020
pubmed: 33852916
PLoS One. 2012;7(2):e31600
pubmed: 22384041
Biomed Pharmacother. 2021 Aug;140:111785
pubmed: 34126316
Rev Med Virol. 2022 May;32(3):e2292
pubmed: 34590761
BMC Med. 2021 Jun 4;19(1):136
pubmed: 34082752
Cell Physiol Biochem. 2017;44(6):2269-2280
pubmed: 29262411
J Virol. 2014 Jan;88(2):1293-307
pubmed: 24227843
Cell Physiol Biochem. 2015;35(6):2472-82
pubmed: 25967876
Pharmacol Res. 2013 May;71:9-18
pubmed: 23428345
Rev Med Liege. 2018 Jul;73(7-8):370-375
pubmed: 30113776
Circ Res. 2020 May 8;126(10):1456-1474
pubmed: 32264791
Exp Dermatol. 2016 Sep;25(9):694-700
pubmed: 27093919
Biomedicines. 2021 Jun 23;9(7):
pubmed: 34201505
Immunity. 2010 Dec 14;33(6):929-41
pubmed: 21145759
Rev Med Virol. 2021 Mar;31(2):e2157
pubmed: 32844538
Lancet Respir Med. 2020 Apr;8(4):420-422
pubmed: 32085846
mBio. 2021 Aug 31;12(4):e0097021
pubmed: 34340553
Database (Oxford). 2010 Aug 05;2010:baq020
pubmed: 20689021
Cytokine. 2001 Aug 21;15(4):175-87
pubmed: 11563878
Drug Dev Res. 2020 Sep;81(6):647-649
pubmed: 32329083
Arch Iran Med. 2021 Feb 01;24(2):139-143
pubmed: 33636983
J Leukoc Biol. 2022 Jun;111(6):1147-1158
pubmed: 34826347
Cell Immunol. 1999 Dec 15;198(2):111-9
pubmed: 10648125
Neoplasia. 2013 Feb;15(2):218-30
pubmed: 23441135
Cell Signal. 2020 Dec;76:109772
pubmed: 32931899
Virol Sin. 2020 Jun;35(3):266-271
pubmed: 32125642
Postgrad Med J. 2020 Apr;96(1134):197-205
pubmed: 31628212
Biochem J. 1998 Aug 1;333 ( Pt 3):581-9
pubmed: 9677316
Hypertens Res. 2021 Aug;44(8):1042-1045
pubmed: 34017093
Nat Rev Microbiol. 2021 Jul;19(7):409-424
pubmed: 34075212
Front Microbiol. 2021 May 14;12:675419
pubmed: 34054782
Protein Cell. 2016 Mar;7(3):159-74
pubmed: 26936847
JAMA. 2020 Mar 17;323(11):1061-1069
pubmed: 32031570
Front Pharmacol. 2020 Jul 29;11:1154
pubmed: 32848763
Adv Biol Regul. 2021 Aug;81:100820
pubmed: 34419773
Pharmacol Res. 2020 Aug;158:104850
pubmed: 32360580
Ther Adv Respir Dis. 2020 Jan-Dec;14:1753466620926800
pubmed: 32436460
Vaccines (Basel). 2021 Apr 29;9(5):
pubmed: 33946736
Viruses. 2012 May;4(5):833-46
pubmed: 22754651
Antiviral Res. 2010 Mar;85(3):551-5
pubmed: 19995578
J Virol. 2013 Jan;87(2):912-22
pubmed: 23135723
J Immunother Cancer. 2020 May;8(1):
pubmed: 32385146
N Engl J Med. 2020 Apr 30;382(18):1708-1720
pubmed: 32109013
ACS Cent Sci. 2020 Mar 25;6(3):315-331
pubmed: 32226821
Exp Mol Med. 2019 Jun 20;51(6):1-15
pubmed: 31221957
Liver Int. 2020 May;40(5):998-1004
pubmed: 32170806
Immunohorizons. 2018 Jul 5;2(6):198-207
pubmed: 31022687
Nutrients. 2021 Jun 24;13(7):
pubmed: 34202578
Lancet Respir Med. 2020 Apr;8(4):e26
pubmed: 32119827
Med Hypotheses. 2021 Jul;152:110609
pubmed: 34048987
Annu Rev Virol. 2016 Sep 29;3(1):533-553
pubmed: 27501259
BMJ. 2018 Oct 24;363:k4209
pubmed: 30355745
PLoS One. 2017 Mar 16;12(3):e0173947
pubmed: 28301543
Mediators Inflamm. 2010;2010:908649
pubmed: 21253506
Pathogens. 2021 May 07;10(5):
pubmed: 34066983
Biochim Biophys Acta Mol Basis Dis. 2021 Dec 1;1867(12):166260
pubmed: 34461258
Hum Immunol. 2022 Jan;83(1):86-98
pubmed: 34583856
Clin Infect Dis. 2020 Jul 28;71(15):762-768
pubmed: 32161940
Ageing Res Rev. 2020 Dec;64:101201
pubmed: 33157320
Front Microbiol. 2019 Jan 29;10:50
pubmed: 30761102
Emerg Microbes Infect. 2020 Dec;9(1):1748-1760
pubmed: 32691695
EClinicalMedicine. 2021 Jun 18;37:100962
pubmed: 34189447
Mediators Inflamm. 2021 Jan 14;2021:8874339
pubmed: 33505220
J Virol. 2005 Jun;79(12):7819-26
pubmed: 15919935
J Gen Virol. 2005 Jul;86(Pt 7):1921-1930
pubmed: 15958670
Curr Neurovasc Res. 2020;17(3):332-337
pubmed: 32334502
J Med Virol. 2020 Nov;92(11):2314-2315
pubmed: 32391920
Cell. 2020 Dec 10;183(6):1735
pubmed: 33306958
J Med Virol. 2020 Sep;92(9):1495-1500
pubmed: 32410266
Interdiscip Sci. 2021 Jun;13(2):153-175
pubmed: 33886097
J Biochem Mol Toxicol. 2021 Mar;35(3):e22656
pubmed: 33094891
Eur J Heart Fail. 2020 Jun;22(6):957-966
pubmed: 32412156
Mol Cell Biol. 1999 Aug;19(8):5289-97
pubmed: 10409720
Crit Care. 2020 Aug 4;24(1):484
pubmed: 32753065
Biomed Pharmacother. 2021 Nov;143:112095
pubmed: 34479017
Front Immunol. 2021 Jul 13;12:690477
pubmed: 34326843
mBio. 2018 Oct 9;9(5):
pubmed: 30301856
Neuropeptides. 2010 Apr;44(2):145-54
pubmed: 20045558
Sci Rep. 2021 May 7;11(1):9803
pubmed: 33963249
Antiviral Res. 2008 Feb;77(2):150-2
pubmed: 18055026
PLoS Pathog. 2010 Feb 05;6(2):e1000756
pubmed: 20140198
Commun Biol. 2021 Mar 5;4(1):290
pubmed: 33674719
Intensive Care Med. 2020 Apr;46(4):586-590
pubmed: 32125455
J Clin Med. 2021 Aug 29;10(17):
pubmed: 34501332
Cell Mol Neurobiol. 2020 Jul;40(5):845-857
pubmed: 31865500
J Invest Dermatol. 1998 Oct;111(4):645-9
pubmed: 9764847
Ther Adv Chronic Dis. 2021 Aug 20;12:20406223211039699
pubmed: 34434540
Nat Rev Drug Discov. 2012 Oct;11(10):763-76
pubmed: 23023676
Annu Rev Microbiol. 1999;53:577-628
pubmed: 10547702
Front Pharmacol. 2021 Sep 17;12:731847
pubmed: 34603047
Cell Death Dis. 2018 Sep 5;9(9):904
pubmed: 30185776
PLoS Pathog. 2021 Sep 3;17(9):e1009885
pubmed: 34478455
Mucosal Immunol. 2016 Sep;9(5):1173-82
pubmed: 26813341
Mol Cell Biol. 2015 Nov;35(21):3622-32
pubmed: 26283728
Gene Rep. 2020 Sep;20:100765
pubmed: 32835132
J Virol. 2014 Jan;88(2):913-24
pubmed: 24198408
BMC Infect Dis. 2020 Dec 21;20(1):963
pubmed: 33349241
Naunyn Schmiedebergs Arch Pharmacol. 2021 Jul;394(7):1589-1593
pubmed: 34151392
Nat Rev Immunol. 2002 May;2(5):364-71
pubmed: 12033742
Front Cell Dev Biol. 2019 May 29;7:91
pubmed: 31192209
Pharmaceuticals (Basel). 2021 Jul 28;14(8):
pubmed: 34451835
Cells. 2020 Dec 13;9(12):
pubmed: 33322168
Immunol Rev. 2006 Jun;211:81-92
pubmed: 16824119
Crit Care. 2019 Jun 28;23(1):235
pubmed: 31253195
Mol Biol Rep. 2021 Dec;48(12):8195-8202
pubmed: 34664162
Pulm Pharmacol Ther. 2011 Apr;24(2):193-8
pubmed: 20951825
Cells. 2021 Feb 27;10(3):
pubmed: 33673459
Natl Sci Rev. 2020 Jun;7(6):1003-1011
pubmed: 34676126
mBio. 2013 Apr 30;4(3):e00165-13
pubmed: 23631916
Inflamm Bowel Dis. 2020 Jun 18;26(7):e64
pubmed: 32342098
Nat Rev Drug Discov. 2020 Mar;19(3):149-150
pubmed: 32127666
Mediators Inflamm. 2017;2017:3958069
pubmed: 28255204
Nat Rev Clin Oncol. 2018 Apr;15(4):234-248
pubmed: 29405201
J Virol. 2010 Sep;84(18):9398-407
pubmed: 20631133
Trials. 2020 Dec 9;21(1):1005
pubmed: 33298149
mSystems. 2020 Jul 28;5(4):
pubmed: 32723797
Genome Res. 2003 Nov;13(11):2498-504
pubmed: 14597658
Curr Opin Immunol. 2010 Feb;22(1):41-7
pubmed: 20061127
Proc Natl Acad Sci U S A. 1996 Aug 20;93(17):9090-5
pubmed: 8799159
J Biol Regul Homeost Agents. 2020 Mar 14;34(2):327-331
pubmed: 32171193
EClinicalMedicine. 2021 May;35:100849
pubmed: 33903855
J Virol. 2007 Jan;81(2):548-57
pubmed: 17108024
Front Immunol. 2021 Feb 22;12:627579
pubmed: 33692801
Cytokine. 2021 Oct;146:155627
pubmed: 34237556
Rev Endocr Metab Disord. 2022 Apr;23(2):151-170
pubmed: 34195965
Front Immunol. 2020 Dec 10;11:598444
pubmed: 33362782
Cancers (Basel). 2019 Jul 05;11(7):
pubmed: 31284467
Interdiscip Sci. 2021 Mar;13(1):44-60
pubmed: 33433784
Biochem J. 1998 Sep 1;334 ( Pt 2):297-314
pubmed: 9716487
Lancet Infect Dis. 2020 Apr;20(4):400-402
pubmed: 32113509
Nat Rev Immunol. 2005 Dec;5(12):917-27
pubmed: 16322745
Gastroenterol Hepatol Bed Bench. 2020 Fall;13(4):374-387
pubmed: 33244381
EBioMedicine. 2021 Jan;63:103153
pubmed: 33279857
Mol Cell Biol. 1999 Apr;19(4):2435-44
pubmed: 10082509
J Neurochem. 2011 Nov;119(4):736-48
pubmed: 21913925
Proc Natl Acad Sci U S A. 2008 Jun 3;105(22):7809-14
pubmed: 18490652
Pharmacol Res. 2020 May;155:104715
pubmed: 32087235
BMJ. 2020 Mar 26;368:m1091
pubmed: 32217556
J Leukoc Biol. 2004 Feb;75(2):163-89
pubmed: 14525967
Int J Mol Sci. 2020 Sep 03;21(17):
pubmed: 32899231
Biochim Biophys Acta. 2005 Jun 30;1741(1-2):4-10
pubmed: 15916886
Autophagy. 2020 Dec;16(12):2131-2139
pubmed: 32964796
J Autoimmun. 2020 May;109:102433
pubmed: 32113704
Stem Cell Rev Rep. 2021 Feb;17(1):266-277
pubmed: 32691370
J Microbiol Immunol Infect. 2020 Jun;53(3):368-370
pubmed: 32205092
Res Pract Thromb Haemost. 2018 Dec 16;3(1):38-43
pubmed: 30656274
Cytokine X. 2020 Jun;2(2):100029
pubmed: 32421092
ISRN AIDS. 2013 Aug 12;2013:954806
pubmed: 24052891
Trends Pharmacol Sci. 2020 Aug;41(8):531-543
pubmed: 32580895
Front Immunol. 2019 Jul 24;10:1736
pubmed: 31396233
Front Immunol. 2020 Jun 16;11:1441
pubmed: 32612615
Phytomedicine. 2020 Nov;78:153296
pubmed: 32890913
Peptides. 2011 Jul;32(7):1447-56
pubmed: 21600945
Clin Exp Immunol. 2007 Feb;147(2):199-207
pubmed: 17223959
Rev Med Virol. 2018 Sep;28(5):e1988
pubmed: 29956408
Arch Virol. 2021 Mar;166(3):675-696
pubmed: 33462671
Antiviral Res. 2017 Jan;137:82-92
pubmed: 27840203
Immunity. 2020 May 19;52(5):731-733
pubmed: 32325025
RSC Adv. 2021 Sep 9;11(48):30132-30147
pubmed: 35480256
Inflammopharmacology. 2021 Feb;29(1):91-100
pubmed: 33159646
J Biol Chem. 2007 Jul 13;282(28):20329-39
pubmed: 17517883
Lancet. 2020 Feb 15;395(10223):497-506
pubmed: 31986264
Front Immunol. 2020 May 01;11:827
pubmed: 32425950
Eur J Clin Microbiol Infect Dis. 2020 Jun;39(6):1021-1026
pubmed: 32285293
Autoimmun Rev. 2020 Jun;19(6):102537
pubmed: 32251717
Signal Transduct Target Ther. 2021 Jul 7;6(1):255
pubmed: 34234112
Virus Res. 2007 Sep;128(1-2):1-8
pubmed: 17532082
Hypertension. 2018 May;71(5):804-810
pubmed: 29581215
PLoS One. 2016 Mar 10;11(3):e0150861
pubmed: 26963721
Intern Emerg Med. 2020 Aug;15(5):759-766
pubmed: 32430651
Med Hypotheses. 2020 Oct;143:109857
pubmed: 32464493
Nat Rev Microbiol. 2016 Jun;14(6):360-73
pubmed: 27174148
Cell. 2012 Jan 20;148(1-2):213-27
pubmed: 22265413
Front Immunol. 2019 Jun 04;10:1265
pubmed: 31275302
Int J Infect Dis. 2020 Jul;96:467-474
pubmed: 32425643
Front Med (Lausanne). 2020 May 22;7:248
pubmed: 32574336
World Acad Sci J. 2020 May;2(3):
pubmed: 32313883
Biomed Pharmacother. 2020 Nov;131:110698
pubmed: 32920514
J Mol Cell Cardiol. 2020 Jul;144:63-65
pubmed: 32422320
Basic Res Cardiol. 2020 Apr 9;115(3):31
pubmed: 32274570
Nat Rev Immunol. 2004 Jul;4(7):499-511
pubmed: 15229469
Cytokine Growth Factor Rev. 2020 Aug;54:24-31
pubmed: 32536564
Pharmacol Rev. 1998 Sep;50(3):357-86
pubmed: 9755287
Nat Commun. 2021 Jun 21;12(1):3818
pubmed: 34155207
Sci China Life Sci. 2020 Mar;63(3):364-374
pubmed: 32048163
Gut. 2016 Dec;65(12):2017-2028
pubmed: 26276683
Annu Rev Pharmacol Toxicol. 2006;46:235-76
pubmed: 16402905
Natl Sci Rev. 2020 Jun;7(6):998-1002
pubmed: 34676125
Nat Rev Immunol. 2013 Jun;13(6):397-411
pubmed: 23702978
Cytokine Growth Factor Rev. 2021 Oct;61:2-15
pubmed: 34183243
Sci Rep. 2021 Jan 15;11(1):1580
pubmed: 33452298
Ann Med Surg (Lond). 2021 Sep;69:102779
pubmed: 34512959
Infect Dis Rep. 2021 Feb 04;13(1):102-125
pubmed: 33557330
Cell. 2021 Apr 15;184(8):2212-2228.e12
pubmed: 33713620
Am J Physiol Lung Cell Mol Physiol. 2018 Jan 01;314(1):L17-L31
pubmed: 28935640
Neurol Res. 2017 Apr;39(4):367-373
pubmed: 28191863
Int J Mol Sci. 2020 Feb 20;21(4):
pubmed: 32093389
Lancet. 2020 Mar 28;395(10229):1033-1034
pubmed: 32192578
J Virol. 2007 Nov;81(21):11620-33
pubmed: 17715225
Cell Mol Immunol. 2020 Aug;17(8):881-883
pubmed: 32555321
Inflamm Bowel Dis. 2011 Feb;17(2):645-54
pubmed: 20848521
Nucleic Acids Res. 2000 Jan 1;28(1):27-30
pubmed: 10592173
Oncogene. 2006 Oct 30;25(51):6844-67
pubmed: 17072332
Braz J Med Biol Res. 2014 Jan;47(1):1-10
pubmed: 24345875
Cell. 2020 Apr 16;181(2):271-280.e8
pubmed: 32142651
Antimicrob Agents Chemother. 2015 Feb;59(2):1088-99
pubmed: 25487801
Lancet Rheumatol. 2021 Apr;3(4):e253-e261
pubmed: 33655218
Immunity. 2020 Jun 16;52(6):971-977.e3
pubmed: 32413330
Int Arch Allergy Immunol. 2008;147(4):299-304
pubmed: 18617749
Nutrients. 2020 Dec 25;13(1):
pubmed: 33375692
Nat Rev Immunol. 2002 Oct;2(10):725-34
pubmed: 12360211
J Virol. 2010 Jan;84(2):1097-109
pubmed: 19889773
J Immunol Res. 2015;2015:272359
pubmed: 26199948
Asian Pac J Allergy Immunol. 2020 Mar;38(1):1-9
pubmed: 32105090
EMBO Mol Med. 2021 Jan 11;13(1):e13426
pubmed: 33179852
Cytokine. 2020 Sep;133:155151
pubmed: 32544563
Acta Pharmacol Sin. 2020 Dec;41(12):1539-1546
pubmed: 33110240
J Pers Med. 2021 Jul 01;11(7):
pubmed: 34357095
Eur J Intern Med. 2020 Jun;76:14-20
pubmed: 32336612
Infez Med. 2021 Jun 1;29(2):167-180
pubmed: 34061781
Cells. 2020 Jan 09;9(1):
pubmed: 31936570
Int J Mol Sci. 2021 May 21;22(11):
pubmed: 34064039
Nature. 2020 Jul;583(7816):459-468
pubmed: 32353859
Nat Med. 2020 May;26(5):681-687
pubmed: 32327758
Front Pharmacol. 2020 Nov 19;11:569849
pubmed: 33424586
Pharmazie. 2021 Aug 1;76(8):342-350
pubmed: 34412732
Nat Rev Cardiol. 2020 May;17(5):259-260
pubmed: 32139904
Biomed Pharmacother. 2021 Jan;133:111008
pubmed: 33227708
Annu Rev Immunol. 2014;32:513-45
pubmed: 24555472
Surg Oncol Clin N Am. 2007 Oct;16(4):711-35, vii
pubmed: 18022541
Pharmacol Res. 2020 Jul;157:104820
pubmed: 32360484
Int J Mol Sci. 2021 Aug 05;22(16):
pubmed: 34445140
Arterioscler Thromb Vasc Biol. 2016 Oct;36(10):2038-47
pubmed: 27562914