Bilberry/red grape juice decreases plasma biomarkers of inflammation and tissue damage in aged men with subjective memory impairment -a randomized clinical trial.
Aged men
Bilberry; blueberry; blueberries
Cytokines
Grape
Inflammation
Memory
Journal
BMC nutrition
ISSN: 2055-0928
Titre abrégé: BMC Nutr
Pays: England
ID NLM: 101672434
Informations de publication
Date de publication:
22 Nov 2021
22 Nov 2021
Historique:
received:
28
10
2020
accepted:
26
10
2021
entrez:
22
11
2021
pubmed:
23
11
2021
medline:
23
11
2021
Statut:
epublish
Résumé
Few randomized clinical trials have explored the health effects of bilberries in humans. The aim was to test the effect of bilberry and red grape-juice consumption on visual memory, motor speed and dexterity as well as inflammatory and tissue damage biomarkers of plasma in aged men with subjective memory impairment. Nine-week double-blind, placebo-controlled, dietary intervention study of aged men (n = 60, age ≥ 67 years) with subjective memory impairment randomized to consume a 50/50 mix of bilberry/red grape-juice or an iso-caloric placebo juice. A selection of Cambridge Cognition Test Battery (CANTAB), Grooved Pegboard tests and blood-sampling for biomarker analysis were performed before and after the intervention. Compared to placebo the selected memory and motor test scores were un-affected by the bilberry/red grape intervention. However, the plasma levels of tissue damage biomarkers decreased significantly more in the bilberry/red grape group. In particular lactate dehydrogenase (LDH) decreased from 362 U/L (median, baseline) to 346 U/L (median, post intervention) in the bilberry/red grape group. Also, several biomarkers of inflammation (EGF, IL6, IL9, IL10 and TNFα) decreased significantly more in the bilberry/red grape group. Furthermore, several plasma polyphenols; p-coumaric acid, hippuric acid, protocatechuic acid, 3HPAA and vanillic acid, increased significantly more in the bilberry/red grape group compared to placebo with the largest increase in p-coumaric acid with 116%; from 2.2 [1.0,5.5] to 4.7 [2.8,8.1] μM/L (median [95% CL]). The results indicate that a nine-week bilberry/red grape juice intervention has no measurable effects on the selected memory scores in aged men experiencing memory problems but decreases the level of biomarkers of inflammation and tissue damage. Whether the dampening effects on inflammation and tissue damage biomarkers have relevance for neuroinflammatory brain pathology remains to be established. Registration number ( ClinicalTrials.gov : NCT00972972 ), September 9, 2009.
Sections du résumé
BACKGROUND
BACKGROUND
Few randomized clinical trials have explored the health effects of bilberries in humans. The aim was to test the effect of bilberry and red grape-juice consumption on visual memory, motor speed and dexterity as well as inflammatory and tissue damage biomarkers of plasma in aged men with subjective memory impairment.
METHODS
METHODS
Nine-week double-blind, placebo-controlled, dietary intervention study of aged men (n = 60, age ≥ 67 years) with subjective memory impairment randomized to consume a 50/50 mix of bilberry/red grape-juice or an iso-caloric placebo juice. A selection of Cambridge Cognition Test Battery (CANTAB), Grooved Pegboard tests and blood-sampling for biomarker analysis were performed before and after the intervention.
RESULTS
RESULTS
Compared to placebo the selected memory and motor test scores were un-affected by the bilberry/red grape intervention. However, the plasma levels of tissue damage biomarkers decreased significantly more in the bilberry/red grape group. In particular lactate dehydrogenase (LDH) decreased from 362 U/L (median, baseline) to 346 U/L (median, post intervention) in the bilberry/red grape group. Also, several biomarkers of inflammation (EGF, IL6, IL9, IL10 and TNFα) decreased significantly more in the bilberry/red grape group. Furthermore, several plasma polyphenols; p-coumaric acid, hippuric acid, protocatechuic acid, 3HPAA and vanillic acid, increased significantly more in the bilberry/red grape group compared to placebo with the largest increase in p-coumaric acid with 116%; from 2.2 [1.0,5.5] to 4.7 [2.8,8.1] μM/L (median [95% CL]).
CONCLUSIONS
CONCLUSIONS
The results indicate that a nine-week bilberry/red grape juice intervention has no measurable effects on the selected memory scores in aged men experiencing memory problems but decreases the level of biomarkers of inflammation and tissue damage. Whether the dampening effects on inflammation and tissue damage biomarkers have relevance for neuroinflammatory brain pathology remains to be established.
TRIAL REGISTRATION
BACKGROUND
Registration number ( ClinicalTrials.gov : NCT00972972 ), September 9, 2009.
Identifiants
pubmed: 34802467
doi: 10.1186/s40795-021-00482-8
pii: 10.1186/s40795-021-00482-8
pmc: PMC8607697
doi:
Banques de données
ClinicalTrials.gov
['NCT00972972']
Types de publication
Journal Article
Langues
eng
Pagination
75Informations de copyright
© 2021. The Author(s).
Références
J Crohns Colitis. 2013 May;7(4):271-9
pubmed: 22883440
Alzheimers Dement. 2008 Jan;4(1 Suppl 1):S98-S108
pubmed: 18632010
Eur J Clin Nutr. 2011 Mar;65(3):394-401
pubmed: 21224867
Food Funct. 2019 Dec 11;10(12):7707-7713
pubmed: 31746877
J Nutr. 2007 Aug;137(8):1951-4
pubmed: 17634269
Am J Geriatr Psychiatry. 2005 Aug;13(8):645-55
pubmed: 16085780
J Chromatogr B Biomed Sci Appl. 1999 Apr 30;727(1-2):179-89
pubmed: 10360437
BMC Med. 2010 Sep 16;8:54
pubmed: 20846424
Crit Rev Immunol. 2001;21(5):427-49
pubmed: 11942558
Int J Mol Sci. 2019 May 10;20(9):
pubmed: 31083327
Lancet. 2016 Jul 30;388(10043):505-17
pubmed: 26921134
Nutr Res. 2016 Dec;36(12):1415-1422
pubmed: 27993193
Br J Nutr. 2015 Oct 14;114(7):1054-63
pubmed: 26227795
Eur J Nutr. 2010 Sep;49(6):345-55
pubmed: 20119859
Mol Nutr Food Res. 2012 Oct;56(10):1501-10
pubmed: 22961907
Pharmacology. 2007;79(1):17-26
pubmed: 17135773
Ageing Res Rev. 2021 May;67:101271
pubmed: 33571701
Lancet. 2006 Apr 15;367(9518):1262-70
pubmed: 16631882
Nat Med. 2007 Nov;13(11):1359-62
pubmed: 17934472
PLoS One. 2014 Dec 12;9(12):e114790
pubmed: 25501421
J Gerontol A Biol Sci Med Sci. 2019 Jun 18;74(7):996-1007
pubmed: 30032176
Crit Rev Food Sci Nutr. 2020;60(2):181-200
pubmed: 30373383
Brain Behav Immun. 2020 Mar;85:96-105
pubmed: 30999017
Prog Neuropsychopharmacol Biol Psychiatry. 2007 Apr 13;31(3):746-51
pubmed: 17289240
J Neuroimmunol. 2002 Jun;127(1-2):160-8
pubmed: 12044988
J Nutr. 2009 Jan;139(1):120-7
pubmed: 19056649
Nutr Neurosci. 2018 May;21(4):297-305
pubmed: 28221821
Neuro Endocrinol Lett. 2008 Feb;29(1):75-9
pubmed: 18283248
Nutr Neurosci. 2006 Oct-Dec;9(5-6):251-8
pubmed: 17263092
Nutr J. 2010 Jan 22;9:3
pubmed: 20096093
Cell Metab. 2008 Aug;8(2):157-68
pubmed: 18599363
Mol Nutr Food Res. 2017 Sep;61(9):
pubmed: 28556578
Rapid Commun Mass Spectrom. 2009 Sep;23(18):2885-90
pubmed: 19670343
Nat Rev Drug Discov. 2006 Jun;5(6):493-506
pubmed: 16732220
Nat Neurosci. 2019 Mar;22(3):401-412
pubmed: 30742114
Brain Res. 2000 Jun 2;866(1-2):211-7
pubmed: 10825496
Nature. 2018 Apr;556(7701):332-338
pubmed: 29643512
J Agric Food Chem. 2010 Apr 14;58(7):3927-32
pubmed: 20073463
An Acad Bras Cienc. 2020 Nov 20;92(4):e20191551
pubmed: 33237140
Compr Gerontol A. 1988 Jun;2(2):87-93
pubmed: 3228822
Metab Brain Dis. 2014 Sep;29(3):593-608
pubmed: 24782046
J Agric Food Chem. 2010 Apr 14;58(7):3996-4000
pubmed: 20047325
J Neuropathol Exp Neurol. 2002 Oct;61(10):914-25
pubmed: 12387457
J Nutr Health Aging. 2012 Jul;16(7):626-30
pubmed: 22836704
Med Clin North Am. 1963 Nov;47:1647-58
pubmed: 14078168
Am J Clin Nutr. 2016 Mar;103(3):775-83
pubmed: 26864371
Biofactors. 2004;22(1-4):145-7
pubmed: 15630270
Neurotoxicol Teratol. 1996 Jul-Aug;18(4):499-504
pubmed: 8866544
Ann N Y Acad Sci. 2009 Aug;1171:385-90
pubmed: 19723080
J Am Diet Assoc. 1998 Jun;98(6):689-91
pubmed: 9627628
Br J Nutr. 2010 Mar;103(5):730-4
pubmed: 20028599
Am J Epidemiol. 2006 Apr 15;163(8):687-93
pubmed: 16510545
Nutr J. 2010 Sep 15;9:37
pubmed: 20843361
J Alzheimers Dis. 2021;79(3):1213-1226
pubmed: 33427745
Dement Geriatr Cogn Disord. 2009;28(4):281-7
pubmed: 19828948
Nutr Neurosci. 2003 Jun;6(3):153-62
pubmed: 12793519
Int Psychogeriatr. 2008 Feb;20(1):1-16
pubmed: 18072981
Int J Neurosci. 2008 Dec;118(12):1659-72
pubmed: 18937113
J Neuroinflammation. 2018 Sep 24;15(1):276
pubmed: 30249283
Nucleic Acids Res. 2007;35(22):7497-504
pubmed: 17947327
Trends Immunol. 2008 May;29(5):211-9
pubmed: 18328784