Stereochemistry of chiral pesticide uniconazole and enantioselective metabolism in rat liver microsomes.

Animals Chromatography, High Pressure Liquid Chromatography, Liquid Microsomes, Liver Molecular Docking Simulation Pesticides Rats Stereoisomerism Tandem Mass Spectrometry Triazoles
Enantioselective metabolism LC-MS/MS spectrometry Molecular docking Rat liver microsomes Uniconazole

Journal

Pesticide biochemistry and physiology
ISSN: 1095-9939
Titre abrégé: Pestic Biochem Physiol
Pays: United States
ID NLM: 1301573

Informations de publication

Date de publication:
Nov 2021
Historique:
received: 10 07 2021
revised: 09 09 2021
accepted: 09 09 2021
entrez: 22 11 2021
pubmed: 23 11 2021
medline: 24 11 2021
Statut: ppublish

Résumé

In this work, stereochemistry of uniconazole enantiomers and their metabolism behaviors in rat liver microsomes have been researched. Significance analysis has been applied in data processing. Absolute configurations of uniconazole enantiomers were identified through vibrational circular dichroism spectroscopy. According to their elution order from the chiral column using the CO

Identifiants

DOI: 10.1016/j.pestbp.2021.104964 PMID: 34802514
pubmed: 34802514
pii: S0048-3575(21)00195-4
doi: 10.1016/j.pestbp.2021.104964
pii:
doi:

Substances chimiques

Pesticides 0
Triazoles 0
uniconazole R4ATA06H50

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

104964

Informations de copyright

Copyright © 2021 Elsevier Inc. All rights reserved.

Auteurs

Dong Guo (D)

School of Chemistry, Guangzhou Key Laboratory of Analytical Chemistry for Biomedicine, South China Normal University, Guangzhou 510006, China; Guangzhou Research & Creativity Biotechnology Co. Ltd., Guangzhou 510663, China.

Rujian He (R)

School of Chemistry, Guangzhou Key Laboratory of Analytical Chemistry for Biomedicine, South China Normal University, Guangzhou 510006, China.

Wenxia Su (W)

School of Chemistry, Guangzhou Key Laboratory of Analytical Chemistry for Biomedicine, South China Normal University, Guangzhou 510006, China.

Chun Zheng (C)

School of Chemistry, Guangzhou Key Laboratory of Analytical Chemistry for Biomedicine, South China Normal University, Guangzhou 510006, China.

Weiguang Zhang (W)

School of Chemistry, Guangzhou Key Laboratory of Analytical Chemistry for Biomedicine, South China Normal University, Guangzhou 510006, China. Electronic address: wgzhang@scnu.edu.cn.

Jun Fan (J)

School of Chemistry, Guangzhou Key Laboratory of Analytical Chemistry for Biomedicine, South China Normal University, Guangzhou 510006, China. Electronic address: fanj@scnu.edu.cn.

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Stereochemistry of chiral pesticide...
questionsmedicales.fr › Techniques d'investigation › Techniques de chimie analytique › Chromatographie › Chromatographie en phase liquide › Chromatographie en phase liquide à haute performance › Stereochemistry of chiral pesticide...
questionsmedicales.fr › Techniques d'investigation › Techniques de chimie analytique › Chromatographie › Chromatographie en phase liquide › Stereochemistry of chiral pesticide...
questionsmedicales.fr › Cellules › Structures cellulaires › Fractions subcellulaires › Microsomes › Microsomes du foie › Stereochemistry of chiral pesticide...
questionsmedicales.fr › Sciences de l'information › Méthodologies informatiques › Simulation numérique › Simulation de docking moléculaire › Stereochemistry of chiral pesticide...
questionsmedicales.fr › Actions chimiques et utilisations › Actions toxiques › Pesticides › Stereochemistry of chiral pesticide...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Rats › Stereochemistry of chiral pesticide...
questionsmedicales.fr › Phénomènes chimiques › Phénomènes de chimie organique › Isomérie › Stéréoisomérie › Stereochemistry of chiral pesticide...
questionsmedicales.fr › Techniques d'investigation › Techniques de chimie analytique › Spectrométrie de masse › Spectrométrie de masse en tandem › Stereochemistry of chiral pesticide...
questionsmedicales.fr › Composés hétérocycliques › Composés hétéromonocycliques › Azoles › Triazoles › Stereochemistry of chiral pesticide...