Macrophage regulation & function in helminth infection.
Alternatively activated macrophages
Helminth infection
Immune regulation
Immunometabolism
Inflammation
Tissue repair
Type 2 immunity
Journal
Seminars in immunology
ISSN: 1096-3618
Titre abrégé: Semin Immunol
Pays: England
ID NLM: 9009458
Informations de publication
Date de publication:
03 2021
03 2021
Historique:
received:
23
07
2021
revised:
03
11
2021
accepted:
06
11
2021
pubmed:
23
11
2021
medline:
5
4
2022
entrez:
22
11
2021
Statut:
ppublish
Résumé
Macrophages are innate immune cells with essential roles in host defense, inflammation, immune regulation and repair. During infection with multicellular helminth parasites, macrophages contribute to pathogen trapping and killing as well as to tissue repair and the resolution of type 2 inflammation. Macrophages produce a broad repertoire of effector molecules, including enzymes, cytokines, chemokines and growth factors that govern anti-helminth immunity and repair of parasite-induced tissue damage. Helminth infection and the associated type 2 immune response induces an alternatively activated macrophage (AAM) phenotype that - beyond driving host defense - prevents aberrant Th2 cell activation and type 2 immunopathology. The immune regulatory potential of macrophages is exploited by helminth parasites that induce the production of anti-inflammatory mediators such as interleukin 10 or prostaglandin E
Identifiants
pubmed: 34802871
pii: S1044-5323(21)00057-9
doi: 10.1016/j.smim.2021.101526
pii:
doi:
Substances chimiques
Chemokines
0
Cytokines
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
101526Informations de copyright
Copyright © 2021 Elsevier Ltd. All rights reserved.