Vestibular Morphological Asymmetry Associated With Motion Sickness Susceptibility.
MRI
asymmetry
inner ear
morphology
motion sickness
resting state
vestibular
Journal
Frontiers in neuroscience
ISSN: 1662-4548
Titre abrégé: Front Neurosci
Pays: Switzerland
ID NLM: 101478481
Informations de publication
Date de publication:
2021
2021
Historique:
received:
23
08
2021
accepted:
14
10
2021
entrez:
22
11
2021
pubmed:
23
11
2021
medline:
23
11
2021
Statut:
epublish
Résumé
Sensory conflicts leading to motion sickness can occur not only between but also within sensory modalities. The vestibular organs are located in both left and right inner ears, and their misalignment can be a source of self-motion related sensory conflicts. In the current study, using inner ear magnetic resonance imaging, we examined whether morphological asymmetry of the bilateral vestibular organs was associated with motion sickness susceptibility. The results showed a larger position asymmetry of bilateral vestibular organs in individuals with high rather than low susceptibility. In addition, vestibular position asymmetry was associated with reciprocal interaction (negative resting state functional connectivity) between vestibular and visuocortical regions in lowly, but not highly, susceptible individuals. In conclusion, these findings suggest that vestibular morphological asymmetry can be a source of sensory conflicts in individuals with dysfunctional reciprocal visuo-vestibular interactions, a putative neural mechanism for resolving sensory conflicts.
Identifiants
pubmed: 34803595
doi: 10.3389/fnins.2021.763040
pmc: PMC8600179
doi:
Types de publication
Journal Article
Langues
eng
Pagination
763040Informations de copyright
Copyright © 2021 Harada, Sugawara, Ito, Wada, Fukunaga, Sadato, Larroque, Demertzi, Laureys and Sakai.
Déclaration de conflit d'intérêts
TH, TS, and HS were employed by Toyota Central R&D Labs. The remaining authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
Références
Front Neurol. 2016 Apr 20;7:58
pubmed: 27148159
Magn Reson Med. 2002 Jun;47(6):1202-10
pubmed: 12111967
Ann N Y Acad Sci. 2015 Apr;1343:10-26
pubmed: 25581203
Eur Spine J. 2016 Feb;25(2):438-43
pubmed: 26077100
Ann N Y Acad Sci. 1999 May 28;871:293-312
pubmed: 10372080
PLoS One. 2020 Apr 29;15(4):e0232417
pubmed: 32349123
Neuroimage. 2007 Aug 1;37(1):90-101
pubmed: 17560126
Acta Otolaryngol. 1975 Sep-Oct;80(3-4):185-96
pubmed: 1101636
Brain. 1998 Sep;121 ( Pt 9):1749-58
pubmed: 9762962
J Vestib Res. 2011;21(3):141-51
pubmed: 21558639
Exp Brain Res. 2006 Nov;175(3):377-99
pubmed: 17021896
J Assoc Res Otolaryngol. 2010 Jun;11(2):145-59
pubmed: 19949828
Jpn J Radiol. 2014 Apr;32(4):191-204
pubmed: 24500139
J Vestib Res. 2011;21(3):161-5
pubmed: 21558641
Neuroimage. 2020 Nov 15;222:117247
pubmed: 32798675
Front Neurol. 2016 Feb 15;7:14
pubmed: 26913019
PLoS One. 2015 May 06;10(5):e0124797
pubmed: 25945925
AJNR Am J Neuroradiol. 1993 Jan-Feb;14(1):47-57
pubmed: 8427111
PLoS One. 2014 Nov 14;9(11):e111554
pubmed: 25396416
Brain Res Bull. 1998 Nov 15;47(5):507-16
pubmed: 10052582
Can J Physiol Pharmacol. 1990 Feb;68(2):294-303
pubmed: 2178753
J Vestib Res. 2006;16(1-2):35-43
pubmed: 16917167
Otol Neurotol. 2017 Jan;38(1):133-138
pubmed: 27755367
Appl Ergon. 2016 Mar;53 Pt B:374-82
pubmed: 26446454
BMC Neurosci. 2009 Aug 25;10:102
pubmed: 19706173
J Neurol. 2016 Apr;263 Suppl 1:S54-64
pubmed: 27083885
Eur J Pediatr. 2014 Nov;173(11):1473-82
pubmed: 24893949
Neuroimage. 2007 Oct 15;38(1):95-113
pubmed: 17761438
PLoS One. 2015 Jul 17;10(7):e0131120
pubmed: 26186348
Neuropsychologia. 1971 Mar;9(1):97-113
pubmed: 5146491