Characteristics of upper urinary tract urothelial carcinoma in the context of bladder cancer: a narrative review.
Urothelial carcinomas (UC)
bladder cancer
upper urinary tract
Journal
Translational andrology and urology
ISSN: 2223-4691
Titre abrégé: Transl Androl Urol
Pays: China
ID NLM: 101581119
Informations de publication
Date de publication:
Oct 2021
Oct 2021
Historique:
received:
02
12
2020
accepted:
08
04
2021
entrez:
22
11
2021
pubmed:
23
11
2021
medline:
23
11
2021
Statut:
ppublish
Résumé
Urothelial carcinomas (UC) arise from the urothelium that covers the proximal urethra, urinary bladder, and the upper urinary tract. In daily routine and clinical trials UC originating from different locations are often treated and investigated in the same manner. However, differences between the two locations seem to be apparent and may question in handling them as a single oncologic entity. In this review we discuss similarities and differences between bladder and upper urinary tract UC and consider their potential impact on treatment strategies. Despite similarities of UC in the bladder (BC) and the upper urinary tract (UTUC), clinicopathologic and molecular differences may question to generally assemble both as a single tumor entity. Treatment standards for UTUC are often adopted from BC. However, a specific investigation in the former may still be meaningful as shown by the example of adjuvant cisplatin based chemotherapy. In conclusion, future investigations should prioritize the understanding of the tumor biology of both BC and UTUC. This may reveal which UTUC can be treated according to treatment standards of BC and in which cases, a separate approach may be more appropriate.
Identifiants
pubmed: 34804846
doi: 10.21037/tau-20-1472
pii: tau-10-10-4036
pmc: PMC8575564
doi:
Types de publication
Journal Article
Review
Langues
eng
Pagination
4036-4050Informations de copyright
2021 Translational Andrology and Urology. All rights reserved.
Déclaration de conflit d'intérêts
Conflicts of Interest: All authors have completed the ICMJE uniform disclosure form (available at http://dx.doi.org/10.21037/tau-20-1472). The series “Management of Advanced Genitourinary Malignancies” was commissioned by the editorial office without any funding or sponsorship. The authors have no conflicts of interest to declare.
Références
Cancer. 2009 Mar 15;115(6):1224-33
pubmed: 19156917
Eur Urol. 2013 Nov;64(5):823-30
pubmed: 23582479
World J Urol. 2017 Mar;35(3):379-387
pubmed: 27604375
CA Cancer J Clin. 2020 Jan;70(1):7-30
pubmed: 31912902
Gend Med. 2008 Dec;5(4):385-94
pubmed: 19108811
Urol Oncol. 2019 Jul;37(7):430-436
pubmed: 30846387
Urology. 2019 Jul;129:146-152
pubmed: 30930207
Cancer Cell. 2016 Jul 11;30(1):27-42
pubmed: 27321955
Nature. 2018 Feb 22;554(7693):544-548
pubmed: 29443960
J Clin Oncol. 2018 Dec 1;36(34):3353-3360
pubmed: 30343614
Cell Death Dis. 2011 Mar 03;2:e124
pubmed: 21368895
Lancet. 2016 May 7;387(10031):1909-20
pubmed: 26952546
Eur Urol. 2016 Dec;70(6):1052-1068
pubmed: 27477528
Urol Oncol. 2019 Sep;37(9):573.e19-573.e29
pubmed: 31358384
Eur Urol Focus. 2019 Mar;5(2):205-223
pubmed: 29154042
Int J Urol. 2008 Apr;15(4):309-13
pubmed: 18380817
Proc Natl Acad Sci U S A. 2007 Jul 17;104(29):12129-34
pubmed: 17620607
J Pathol. 2017 May;242(1):113-125
pubmed: 28195647
Nat Rev Clin Oncol. 2018 Apr;15(4):203-204
pubmed: 29255240
Lancet Oncol. 2017 Mar;18(3):312-322
pubmed: 28131785
Urology. 2000 Mar;55(3):368-71
pubmed: 10699612
Cancer Res. 1994 Feb 1;54(3):784-8
pubmed: 8306342
Eur Urol. 2012 Jul;62(1):100-14
pubmed: 22381168
Nat Med. 2019 Nov;25(11):1706-1714
pubmed: 31686036
Cancer Res. 2002 Feb 1;62(3):809-18
pubmed: 11830537
BJU Int. 2009 Nov;104(10):1436-40
pubmed: 19689473
Eur Urol. 2016 May;69(5):855-62
pubmed: 26343003
J Clin Oncol. 2001 Feb 1;19(3):666-75
pubmed: 11157016
BJU Int. 2010 Feb;105(3):300-8
pubmed: 19912200
J Urol. 2017 Feb;197(2):287-295
pubmed: 27664578
Nature. 2000 Aug 17;406(6797):747-52
pubmed: 10963602
BJU Int. 2019 Feb 23;:
pubmed: 30801918
Eur Urol. 2020 Apr;77(4):420-433
pubmed: 31563503
Clin Cancer Res. 2012 Jun 15;18(12):3377-86
pubmed: 22553347
J Urol. 2002 Jun;167(6):2408-12
pubmed: 11992047
World J Urol. 2011 Aug;29(4):481-6
pubmed: 20886219
Clin Genitourin Cancer. 2018 Dec;16(6):e1237-e1242
pubmed: 30217764
Oncol Rep. 2004 Apr;11(4):745-51
pubmed: 15010867
Cancer Cell. 2014 Feb 10;25(2):152-65
pubmed: 24525232
J Urol. 2018 Jul;200(1):68-73
pubmed: 29307680
Urol Oncol. 2009 May-Jun;27(3):258-62
pubmed: 18440839
Eur Urol. 2017 Oct;72(4):641-649
pubmed: 28601352
Nat Rev Cancer. 2005 Sep;5(9):713-25
pubmed: 16110317
J Urol. 2020 Jun;203(6):1075-1084
pubmed: 31479406
Clin Cancer Res. 2019 Feb 1;25(3):967-976
pubmed: 30352907
Eur J Surg Oncol. 2016 Nov;42(11):1625-1635
pubmed: 27612412
Eur Urol Oncol. 2019 Nov;2(6):625-642
pubmed: 31601522
Eur J Cancer. 2013 May;49(8):1889-97
pubmed: 23466126
BJU Int. 2005 Apr;95(6):791-3
pubmed: 15794784
J Urol. 2000 Jan;163(1):68-71; discussion 71-2
pubmed: 10604316
Brief Bioinform. 2019 Mar 25;20(2):572-584
pubmed: 29659698
Cancer Res. 2010 May 1;70(9):3463-72
pubmed: 20406976
World J Urol. 2011 Aug;29(4):457-63
pubmed: 21656173
Eur Urol. 2015 Dec;68(6):970-7
pubmed: 26278805
Lancet Oncol. 2015 Jan;16(1):76-86
pubmed: 25498218
Eur Urol. 2016 Sep;70(3):458-66
pubmed: 26149669
J Endourol. 2020 May;34(5):573-580
pubmed: 32164441
Nature. 2014 Mar 20;507(7492):315-22
pubmed: 24476821
Urol Int. 2015;94(4):383-9
pubmed: 25833466
JAMA. 2011 Aug 17;306(7):737-45
pubmed: 21846855
Eur J Cancer. 2018 May;95:52-58
pubmed: 29635144
Urol Oncol. 2010 Jul-Aug;28(4):401-8
pubmed: 20610278
Eur Urol. 2018 Jan;73(1):111-122
pubmed: 28867446
Eur Urol. 2014 Jul;66(1):42-54
pubmed: 24018020
J Urol. 2004 Jun;171(6 Pt 1):2186-90, quiz 2435
pubmed: 15126782
Int Urol Nephrol. 2015 Jun;47(6):951-8
pubmed: 25894962
Eur Urol. 2001 Aug;40(2):144-50
pubmed: 11528191
Eur Urol. 2017 Oct;72(4):544-554
pubmed: 28390739
Cell. 2017 Oct 19;171(3):540-556.e25
pubmed: 28988769
Hum Pathol. 2012 Oct;43(10):1573-82
pubmed: 22417847
Lancet. 2020 Apr 18;395(10232):1268-1277
pubmed: 32145825
Oncologist. 2016 Jun;21(6):708-15
pubmed: 27053504
Kidney Int. 2012 Mar;81(6):513-5
pubmed: 22373701
Clin Cancer Res. 2009 Oct 1;15(19):6008-17
pubmed: 19789314
Nat Commun. 2019 Jul 5;10(1):2977
pubmed: 31278255
J Urol. 2008 Apr;179(4):1302-5; discussion 1305-6
pubmed: 18289593
Eur J Cancer. 2013 Apr;49(6):1374-403
pubmed: 23485231
Eur Urol. 2021 Jan;79(1):82-104
pubmed: 32360052
Eur Urol. 2014 Mar;65(3):650-8
pubmed: 24070577
Urology. 2003 Dec;62(6):1134-8
pubmed: 14665377
Urol Oncol. 2009 Jan-Feb;27(1):3-7
pubmed: 18367107
Eur Urol. 2005 Aug;48(2):189-199; discussion 199-201
pubmed: 15939530
Eur Urol. 2019 Jun;75(6):961-964
pubmed: 30851984
Proc Natl Acad Sci U S A. 2014 Feb 25;111(8):3110-5
pubmed: 24520177
JCO Precis Oncol. 2018;2018:
pubmed: 30854504
Nat Rev Cancer. 2015 Jan;15(1):25-41
pubmed: 25533674
Urol Oncol. 2017 Jul;35(7):458.e9-458.e15
pubmed: 28347659
Oncogene. 2000 Dec 14;19(54):6317-23
pubmed: 11175346
Eur Urol. 2016 Jul;70(1):106-119
pubmed: 26996659
Oncotarget. 2017 Jan 31;8(5):7464-7476
pubmed: 27448978
Eur Urol. 2016 Feb;69(2):231-44
pubmed: 26091833
J Clin Oncol. 2011 Jun 1;29(16):2171-7
pubmed: 21502557
World J Urol. 2020 Aug;38(8):1895-1904
pubmed: 31676912
Med Arch. 2017 Dec;71(6):430-433
pubmed: 29416205
J Urol. 2012 Aug;188(2):398-404
pubmed: 22698626
Eur Urol. 2011 Nov;60(5):955-60
pubmed: 21807456
JCI Insight. 2016 Mar 17;1(3):e85902
pubmed: 27699256
Urol Int. 2013;91(3):291-6
pubmed: 23948770
Int J Mol Sci. 2020 Aug 07;21(16):
pubmed: 32784716