Prepectoral breast reconstruction: an ideal approach to bilateral risk-reducing mastectomy.
BRCA1
Mammaplasty
acellular dermal matrix (ADM)
prophylactic mastectomy
Journal
Gland surgery
ISSN: 2227-684X
Titre abrégé: Gland Surg
Pays: China (Republic : 1949- )
ID NLM: 101606638
Informations de publication
Date de publication:
Oct 2021
Oct 2021
Historique:
received:
25
05
2021
accepted:
26
08
2021
entrez:
22
11
2021
pubmed:
23
11
2021
medline:
23
11
2021
Statut:
ppublish
Résumé
Bilateral risk-reducing mastectomy (BRRM) has increased its popularity in the last years because of its aim to minimise the chances of developing breast cancer in high-risk patients. Women undergoing this procedure must be considered highly demanding patients given the need to combine aesthetical, functional and preventive desires. This study aims to present the authors' experience in performing BRRM followed by single-stage prepectoral reconstruction (PPBR) with implant completely covered by acellular dermal matrix (ADM) and to report indications, surgical techniques, functional and aesthetic results. A single-centre prospective data collection was carried out from January 2017 to January 2021 of patients at high risk of developing breast cancer undergoing BRRM and immediate PPBR with ADM. Patients were subdivided into two groups according to the breast shape: Group A had small and medium size breasts and Group B had large and ptotic breasts. Oncological and surgical outcomes were collected. Satisfaction with reconstruction and related quality of life were evaluated through the BREAST-Q questionnaire. A total of twenty-three patients met the inclusion criteria. Seventeen patients were included in group A and six patients in group B. Average follow-up was 18.4 months. Minor complications occurred in four breasts: one seroma, one hematoma and two cases of wound dehiscence. Capsular contracture was not observed. All patients were satisfied with the final result according to the post-operative BREAST-Q questionnaire. Immediate prepectoral breast reconstruction could represent the ideal reconstruction option after BRRM and should be offered to all women that fulfil the inclusion criteria.
Sections du résumé
BACKGROUND
BACKGROUND
Bilateral risk-reducing mastectomy (BRRM) has increased its popularity in the last years because of its aim to minimise the chances of developing breast cancer in high-risk patients. Women undergoing this procedure must be considered highly demanding patients given the need to combine aesthetical, functional and preventive desires. This study aims to present the authors' experience in performing BRRM followed by single-stage prepectoral reconstruction (PPBR) with implant completely covered by acellular dermal matrix (ADM) and to report indications, surgical techniques, functional and aesthetic results.
METHODS
METHODS
A single-centre prospective data collection was carried out from January 2017 to January 2021 of patients at high risk of developing breast cancer undergoing BRRM and immediate PPBR with ADM. Patients were subdivided into two groups according to the breast shape: Group A had small and medium size breasts and Group B had large and ptotic breasts. Oncological and surgical outcomes were collected. Satisfaction with reconstruction and related quality of life were evaluated through the BREAST-Q questionnaire.
RESULTS
RESULTS
A total of twenty-three patients met the inclusion criteria. Seventeen patients were included in group A and six patients in group B. Average follow-up was 18.4 months. Minor complications occurred in four breasts: one seroma, one hematoma and two cases of wound dehiscence. Capsular contracture was not observed. All patients were satisfied with the final result according to the post-operative BREAST-Q questionnaire.
CONCLUSIONS
CONCLUSIONS
Immediate prepectoral breast reconstruction could represent the ideal reconstruction option after BRRM and should be offered to all women that fulfil the inclusion criteria.
Identifiants
pubmed: 34804886
doi: 10.21037/gs-21-339
pii: gs-10-10-2997
pmc: PMC8575706
doi:
Types de publication
Journal Article
Langues
eng
Pagination
2997-3006Informations de copyright
2021 Gland Surgery. All rights reserved.
Déclaration de conflit d'intérêts
Conflicts of Interest: All authors have completed the ICMJE uniform disclosure form (available at https://dx.doi.org/10.21037/gs-21-339). The authors have no conflicts of interest to declare.
Références
Breast Cancer Res Treat. 2012 Jun;133(2):735-40
pubmed: 22240989
Cancer Epidemiol Biomarkers Prev. 2012 Mar;21(3):445-55
pubmed: 22328347
Gland Surg. 2019 Feb;8(1):53-60
pubmed: 30842928
Ann Surg Oncol. 2015 Feb;22(2):370-6
pubmed: 25023546
Plast Reconstr Surg. 2018 May;141(5):1077-1084
pubmed: 29697602
Plast Reconstr Surg. 2010 Mar;125(3):818-29
pubmed: 20195110
Aesthet Surg J. 2018 Apr 6;38(5):519-526
pubmed: 29365064
Ann Plast Surg. 2018 Mar;80(3):212-216
pubmed: 28984661
Plast Reconstr Surg. 2019 Jan;143(1):236e
pubmed: 30286044
N Engl J Med. 1999 Jan 14;340(2):77-84
pubmed: 9887158
J Clin Oncol. 2004 Mar 15;22(6):1055-62
pubmed: 14981104
Plast Reconstr Surg. 2017 Nov;140(5S Advances in Breast Reconstruction):51S-59S
pubmed: 29064922
Breast J. 2017 Nov;23(6):670-676
pubmed: 28481477
J Plast Reconstr Aesthet Surg. 2010 Feb;63(2):332-8
pubmed: 19071075
Adv Exp Med Biol. 2019;1152:9-29
pubmed: 31456177
Eur J Surg Oncol. 2013 May;39(5):425-9
pubmed: 23321393
Ann Surg Oncol. 2007 Feb;14(2):686-94
pubmed: 17103066
Plast Reconstr Surg. 2017 Nov;140(5S Advances in Breast Reconstruction):7S-13S
pubmed: 29064917
Breast J. 2018 Mar;24(2):180-183
pubmed: 28703387
Plast Reconstr Surg Glob Open. 2017 Sep 19;5(9):e1488
pubmed: 29062655
J Plast Reconstr Aesthet Surg. 2019 Oct;72(10):1700-1738
pubmed: 31300220
Clin Cancer Res. 2012 Jan 15;18(2):400-7
pubmed: 22252256
Plast Reconstr Surg. 2018 Sep;142(3):607-610
pubmed: 29878997
Plast Reconstr Surg. 2015 Jun;135(6):1540-1544
pubmed: 26017590
Plast Reconstr Surg. 2016 Aug;138(2):329-337
pubmed: 27064232
Br J Surg. 2015 Oct;102(11):1354-9
pubmed: 26313374
Clin Plast Surg. 2018 Jan;45(1):129-136
pubmed: 29080654
J Plast Reconstr Aesthet Surg. 2015 Feb;68(2):162-7
pubmed: 25455288
N Engl J Med. 2015 Jun 4;372(23):2243-57
pubmed: 26014596
Eur Rev Med Pharmacol Sci. 2020 Jul;24(14):7845-7854
pubmed: 32744712
Clin Breast Cancer. 2018 Aug;18(4):e703-e711
pubmed: 29275104
JAMA Surg. 2018 Feb 1;153(2):123-129
pubmed: 28903167
Breast. 2019 Aug;46:48-51
pubmed: 31082761
Plast Reconstr Surg. 2017 Dec;140(6S Prepectoral Breast Reconstruction):49S-52S
pubmed: 29166348
Plast Reconstr Surg. 1995 Oct;96(5):1119-23; discussion 1124
pubmed: 7568488
Eur Rev Med Pharmacol Sci. 2016 Dec;20(24):5058-5066
pubmed: 28051266
Plast Reconstr Surg. 2019 May;143(5):1311-1319
pubmed: 31033812
J Surg Oncol. 2020 Oct;122(5):848-860
pubmed: 32786089
Aesthetic Plast Surg. 2020 Jun;44(3):664-672
pubmed: 31970455
BMC Cancer. 2008 May 30;8:155
pubmed: 18513387
Breast J. 2016 Jan-Feb;22(1):10-7
pubmed: 26782950
Plast Reconstr Surg Glob Open. 2016 May 27;4(5):e708
pubmed: 27579232
JPRAS Open. 2018 Jan 31;15:74-80
pubmed: 32158802
Am J Hum Genet. 2003 May;72(5):1117-30
pubmed: 12677558
Aesthetic Plast Surg. 2018 Dec;42(6):1439-1446
pubmed: 29987488
J Plast Reconstr Aesthet Surg. 2017 Nov;70(11):1527-1536
pubmed: 28736191
World J Surg. 2019 Sep;43(9):2262-2270
pubmed: 31119358
Gland Surg. 2019 Feb;8(1):11-18
pubmed: 30842923
ANZ J Surg. 2017 Jun;87(6):493-498
pubmed: 25266930
J Clin Oncol. 2008 Aug 20;26(24):3943-9
pubmed: 18711183
Plast Reconstr Surg. 2009 Aug;124(2):345-353
pubmed: 19644246